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Lung Cancer News
October 17, 2019
Cancer Data Provide Insights Into Occurrence, Overdiagnosis, and Treatment Advances
Oct. 2, 2019 — Investigators analyzed 40 years of cancer burden data and examined patterns of incidence and mortality for various cancers, finding examples for which incidence and mortality moved in concert and ... read more
Pathway Found for Treatment-Resistant Lung Cancer
Sep. 23, 2019 — A big way chemotherapy works is by prompting cancer cells to commit suicide, and scientists have found a pathway the most common lung cancer walks to avoid death. Scientists have found a first step ... read more
Combination Therapies Could Help Treat Fatal Lung Cancers
Sep. 18, 2019 — Combining a new class of drug with two other compounds can significantly shrink lung tumors in mice and human cancer cells, new research shows. The study looked at G12C KRAS inhibitors, a new type of ... read more
Cancer Cells Turn to Cannibalism to Survive Chemotherapy, Study Suggests
Sep. 18, 2019 — Researchers have discovered that some cancer cells survive chemotherapy by eating their neighboring tumor cells. The study suggests that this act of cannibalism provides these cancer cells with the ... read more
Same but Different: Unique Cancer Traits Key to Targeted Therapies
Sep. 13, 2019 — Researchers have discovered that the key to personalized therapies for some types of lung cancers may be to focus on their differences, not their ... read more
Role of Nuclear Glycogen in Non-Small Cell Lung Cancers
Sep. 12, 2019 — Researchers have made a breakthrough discovery that solves a mystery long forgotten by science and have identified a potentially novel avenue in pre-clinical models to treat non-small cell lung ... read more
Patients Taking Nivolumab Experience Five-Fold Increase in Overall Survival Compared to Chemotherapy
Sep. 10, 2019 — Pooled data on two clinical trials demonstrate patients taking nivolumab realized a greater than five-fold increase in five-year overall survival rate compared with the chemotherapy ... read more
Durvalumab Combined With Chemotherapy Improves Overall Survival in Patients With Lung Cancer
Sep. 9, 2019 — Adding immunotherapy in the form of durvalumab to chemotherapy improves overall survival in patients with extensive-stage small cell lung cancer, according to new ... read more
Gene Mutations Coordinate to Drive Malignancy in Lung Cancer
Aug. 27, 2019 — Scientists have shown exactly how mutations in two different genes coordinate to drive the development of malignant lung tumors, according to a new ... read more
New Drug Combination Shows Promising Activity in Non-Small Cell Lung Cancer Patients
Aug. 27, 2019 — Patients with non-small cell lung cancer (NSCLC) now have more improved treatment options compared to standard of care with the addition of several ... read more
Aug. 23, 2019 — Researchers have discovered a new way to stop harmful inflammation in the lungs due to sepsis and injury. They found a ... read more
Possible New Treatment Strategy for Lung Cancer
Aug. 19, 2019 — It is estimated there will be roughly 228,000 new lung cancer cases this year, and nearly 30% of those patients will have mutations in the KRAS pathway. This type of mutation makes the cancer more ... read more
Researchers Identify Subtypes of Squamous Cell Lung Cancer
Aug. 8, 2019 — Despite improved knowledge of the molecular alterations in SCC, little is understood about how the alterations contribute to the development of the cancer and how potential vulnerabilities could be ... read more
Discovery of Distinct Lung Cancer Pathways May Lead to More Targeted Treatments
Aug. 1, 2019 — Known for its poor prognosis, lung adenocarcinoma is the most common type of lung cancer, responsible for about 4 of 10 diagnoses. Researchers can now distinguish between two pathways where this ... read more
Two Therapeutic Targets Identified for Deadly Lung Cancer
July 26, 2019 — The vast majority of deadly lung cancer cases (85 percent) are termed non-small-cell lung carcinomas (NSCLCs), which often contain a mutated gene called LKB1. Researchers have now discovered ... read more
Unlocking Therapies for Hard-to-Treat Lung Cancers
July 25, 2019 — Around 85 percent of lung cancers are classified as non-small-cell lung cancers, or NSCLCs. Some patients with these cancers can be treated with targeted genetic therapies, and some benefit from ... read more
Targeting Old Bottleneck Reveals New Anticancer Drug Strategy
July 22, 2019 — The enzyme ribonucleotide reductase is a bottleneck for cancer cell growth. Scientists have identified a way of targeting ribonucleotide reductase that may avoid the toxicity of previous approaches, ... read more
Study Identifies Potential Markers of Lung Cancer
July 16, 2019 — Researchers identify markers that can distinguish between major subtypes of lung cancer and can accurately identify lung cancer ... read more
Pairing Targeted Drugs for Breast and Lung Cancer Could Overcome Treatment Resistance
July 11, 2019 — Targeted drugs for breast and lung cancer could be used together to overcome resistance to treatment in several different tumour types, a new study shows. Scientists discovered that when the breast ... read more
New Alternate Cell Growth Pathway Could Lead to Better Treatments for Metastatic Cancers
July 11, 2019 — A new study has found that the gene, mEAK-7, which they discovered last year, may play a key role in cancer metastasis. By comparing mEAK-7 expression levels in normal and cancer cells, they found ... read more
Cancer Scientists Identify New Drug Target for Multiple Tumor Types
July 11, 2019 — A dysfunctional enzyme involved in building cancer cell membranes helps fuel tumor growth; when it's disabled or depleted in mouse models, tumors shrank ... read more
Response to Gene-Targeted Drugs Depends on Cancer Type
July 1, 2019 — Cancers with the same genetic weaknesses respond differently to targeted drugs depending on the tumour type of the patient, new research reveals. The study is set to prompt changes in thinking around ... read more
Potential Breakthrough in Understanding Tumor Dormancy
May 21, 2019 — Scientists may have uncovered a primary method through which cancer cells exist undetected in an organism and received more than $1 million to investigate the potential for novel therapeutics that ... read more
Conquering Cancer's Infamous KRAS Mutation
May 14, 2019 — Scientists have shown that a compound called PHT-7.3 shrinks KRAS-driven tumors in mice. In contrast to directly targeting mutant KRAS, the potential drug candidate targets the protein's partner ... read more
Lung Cancer Under-Recognized in People Who Have Never Smoked
Apr. 26, 2019 — Lung cancer in people who have never smoked is more common than most people think, and on the rise. Historically strong, and correct, messaging on smoking and lung cancer has inadvertently ... read more
Biologists Design New Molecules to Help Stall Lung Cancer
Apr. 23, 2019 — Scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolizing molecule called heme. In a preclinical ... read more
Some Patients With Imminently Fatal Cancer Still Receive Treatment
Apr. 15, 2019 — Patients who died within one month of being newly diagnosed with metastatic cancer in the United States received ineffective surgery, chemotherapy, radiation, and hormonal ... read more
Precise Decoding of Breast Cancer Cells Creates New Option for Treatment
Apr. 15, 2019 — Researchers have investigated the varying composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of ... read more
'Fingerprint Database' Could Help Scientists to Identify New Cancer Culprits
Apr. 15, 2019 — Scientists have developed a catalogue of DNA mutation 'fingerprints' that could help doctors pinpoint the environmental culprit responsible for a patient's tumor - including showing ... read more
Radiomics Predicts Who Will Benefit from Chemotherapy
Mar. 20, 2019 — Using data from computed tomography (CT) images, researchers may be able to predict which lung cancer patients will respond to chemotherapy, according to a new ... read more
Artificial Intelligence Cuts Lung Cancer Screening False Positives
Mar. 12, 2019 — Right now, 96 percent of people who screen positive for lung cancer don't actually have a malignant growth. Machine learning can rule out cancer in a third of them, saving time, money and ... read more
Imaging Technique Finds Differences Between Radiation-Sensitive and Resistant Tumors
Mar. 11, 2019 — Researchers have begun pilot clinical trials using an imaging technique called Raman spectroscopy, which offers promise for guided cancer treatment and could spare some patients of the toxic side ... read more
Precision Drugs Could Unmask Cancers to Immune System and Boost Effects of Immunotherapy
Mar. 8, 2019 — Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from immunotherapy, a new study ... read more
Increased Muscle Mass Improves Response to Cancer Treatment
Mar. 4, 2019 — Researchers have found that sarcopenia, a condition characterized by decreased skeletal muscle mass, is strongly associated with poor treatment outcomes in lung cancer patients in response to ... read more
Smokers Often Misunderstand Health Risks of Smokeless Tobacco Product, Study Finds
Mar. 4, 2019 — American smokers mistakenly think that using snus, a type of moist snuff smokeless tobacco product, is as dangerous as smoking tobacco, according to a study. The study provides new research on what ... read more
A New Machine Learning Model Can Classify Lung Cancer Slides at the Pathologist Level
Mar. 4, 2019 — Researchers have developed a deep neural network to classify lung cancer subtypes on histopathology slides and found that it performed on par with three practicing pathologists. The study ... read more
Electronic Cigarettes Linked to Wheezing in Adults, New Study Finds
Feb. 28, 2019 — People who vaped were nearly twice as likely to experience wheezing compared to people who didn't use tobacco products, according to a new study. The findings are consistent with past research ... read more
New Microfluidics Device Can Detect Cancer Cells in Blood
Feb. 25, 2019 — Researchers have developed a device that can isolate individual cancer cells from patient blood ... read more
Artificial Lung Cancer Tissue Could Help Find New Drug Treatments
Feb. 25, 2019 — A 3D hydrogel is helping researchers to quickly screen hundreds of potential drugs for their ability to fight highly invasive ... read more
Advancing Therapy by Measuring the 'Games' Cancer Cells Play
Feb. 18, 2019 — Despite rapid advances in targeted therapies for cancer, tumors commonly develop resistance to treatment. When resistance emerges, tumor cells continue to grow unchecked, despite all attempts to slow ... read more
Changes in Lung Cells Seen Almost Immediately After Contact With Low-Molecular Weight PAHs
Feb. 11, 2019 — A new study shows cancer-promoting changes in lung cells as soon as 30 minutes after exposure to low-molecular weight PAHs, adding further evidence that regulators may be underestimating the risk of ... read more
New Heated Tobacco Device Causes Same Damage to Lung Cells as E-Cigs and Smoking, Study Finds
Feb. 11, 2019 — A new study that directly compares new heated tobacco devices with vaping and traditional cigarettes shows that all three are toxic to human lung ... read more
Researchers Develop Human Cell-Based Model to Study Small Cell Lung Cancer
Feb. 8, 2019 — Researchers have used human embryonic stem cells to create a new model system that allows them to study the initiation and progression of small cell lung cancer (SCLC). The study reveals the distinct ... read more
Graphene Biosensor Could Provide Early Lung Cancer Diagnosis
Feb. 4, 2019 — The wonder-material graphene could hold the key to unlocking the next generation of advanced, early stage lung cancer ... read more
Bacteria Promote Lung Tumor Development, Study Suggests
Jan. 31, 2019 — Cancer biologists have discovered a mechanism that lung tumors exploit to promote their own survival: The tumors alter bacterial populations within the lung, provoking the immune system to create an ... read more
New Mechanism to 'Activate' the Immune System Against Cancer
Jan. 4, 2019 — A new mechanism for activating the immune system against cancer cells allows immune cells to detect and destroy cancer cells better than before, and most effectively in lung cancer and ... read more
Tumors Backfire on Chemotherapy
Jan. 1, 2019 — Chemotherapy is an effective treatment for breast cancer, yet some patients develop metastasis in spite of it. Researchers have now discovered that chemotherapy-treated mammary tumors produce small ... read more
Breast Cancer Drugs Could Help Treat Resistant Lung Cancers
Dec. 26, 2018 — A class of drugs used to treat certain breast cancers could help to tackle lung cancers that have become resistant to targeted therapies, a new study suggests. The research found that lung tumors in ... read more
Checkmating Tumors
Nov. 28, 2018 — Chess and cancer research have one thing in common: one must act strategically to defeat the opponent. And that's exactly what scientists are doing. They are seeking to selectively make only ... read more
Proposed Cancer Treatment May Boost Lung Cancer Stem Cells, Study Warns
Nov. 20, 2018 — Epigenetic therapies -- targeting enzymes that alter what genes are turned on or off in a cell -- are of growing interest in the cancer field as a way of making a cancer less aggressive or less ... read more
Genetic 'Whodunnit' for Cancer Gene Solved
Nov. 8, 2018 — Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, researchers have solved the long-standing ... read more
Big-Picture Approach to Understanding Cancer Will Speed New Treatments
Oct. 18, 2018 — The new approach lets scientists examine the cumulative effect of multiple gene mutations, providing a much more complete picture of cancers' ... read more
A Bad Influence: Interplay Between Tumor Cells and Immune Cells
Oct. 16, 2018 — Research has yielded new insights into the environment surrounding different types of lung tumors, and described how these complex cell ecosystems may in turn ultimately affect response to ... read more
Lung Cancer Deaths Are 28 Percent Lower in California
Oct. 10, 2018 — Early adoption of tobacco control efforts in California lead to fewer people ever smoking, reduced the amount used by those who do smoke and helped smokers quit at a younger age -- when their risk of ... read more
Novel Technology Enables Detection of Early-Stage Lung Cancer When Surgical Cure Still Is Possible
Oct. 8, 2018 — To improve outcomes for patients with non-small-cell lung carcinoma researchers are developing a blood test to detect lung cancer earlier in the disease. A report describes a new technology, electric ... read more
Aggressive Prostate and Lung Cancers Are Driven by Common Mechanisms, Researchers Find
Oct. 4, 2018 — Researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to ... read more
A Grape Constituent Protects Against Cancer
Oct. 3, 2018 — Lung cancer is the deadliest form of cancer in the world, and 80% of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed. A team of ... read more
How a Sleeping Cancer Awakens and Metastasizes
Sep. 27, 2018 — Scientists have determined one of the ways in which cancers in remission can spring back into action. This knowledge has inspired a new treatment idea designed to prevent cancer recurrence and ... read more
Lung Cancer Drug Could Be Repurposed to Target 'Zombie' Proteins Linked to Leukemia
Sep. 25, 2018 — A new study highlights how a clinically approved lung cancer drug could potentially be 'repurposed' to design new treatments for future cancer therapies. The research focuses on a protein ... read more
Hybrid Operating Room Streamlines Diagnosis, Treatment of Lung Cancer
Sep. 25, 2018 — Representing a paradigm shift in thoracic surgery, the hybrid operating room combines three techniques into a single appointment eliminating multiple clinical visits for improved patient experience ... read more
Computational Imaging: Looking to Immune Cell Shapes to Predict How Well Body Will Fight Lung Cancers
Sep. 20, 2018 — Researchers have discovered how to quickly and accurately predict which lung cancer patients will benefit from chemotherapy by analyzing the arrangement -- not the number -- of cells the body sends ... read more
CRISPR Screen Reveals New Targets in More Than Half of All Squamous Cell Carcinomas
Sep. 18, 2018 — Researchers sheds light on p63 activity in squamous cell carcinoma of the lung, providing an actionable path forward to drug development against this known cause of ... read more
Chemotherapy May Lead to Early Menopause in Young Women With Lung Cancer
Aug. 29, 2018 — A new study suggests chemotherapy may cause acute amenorrhea leading to early menopause in women with lung cancer. The study is the first to comment on amenorrhea rates in women younger than 50, ... read more
Insight Into Development of Lung Cancer
Aug. 18, 2018 — Lung cancer results from effects of smoking along with multiple genetic components. A new study identifies two main pathways for the role of chromosome 15q25.1 -- a leader in increasing ... read more
Finally, a Potential New Approach Against KRAS-Driven Lung Cancer
Aug. 9, 2018 — A new study shows KRAS-driven lung cancers are also marked by high levels of 'gel-forming mucins,' as seen in some forms of asthma, chronic obstructive pulmonary disease and cystic ... read more
Lung Cancer Mortality Rates Among Women Projected to Increase by Over 40 Percent by 2030
Aug. 1, 2018 — The global age-standardized lung cancer mortality rate among women is projected to increase by 43 percent from 2015 to 2030, according to an analysis of data from 52 countries. The global ... read more
Products of Omega-3 Fatty Acid Metabolism May Have Anticancer Effects
July 13, 2018 — A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer's growth and spread, researchers report in a new study in mice. In mice with tumors of osteosarcoma ... read more
Brain Metastases Common and Difficult to Treat in ROS1 Lung Cancer
July 10, 2018 — Brain metastases were found to be fairly common in stage IV ROS1-positive cancers and in 47 percent of ROS1 patients, the brain was the first and only site of ... read more
Drug's Impact on Amino Acid Transporter May Offer Non-Small Cell Lung Cancer Patients New Hope
July 10, 2018 — An amino acid transporter named xCT may affect the growth and progression of non-small cell lung cancer, a discovery that may predict the five-year survival rate of patients suffering from this ... read more
Simple Test to Predict Rare Cancers' Likely Spread
July 9, 2018 — Circulating tumor cell clusters in the blood of head and neck patients with locally and regionally advanced cancer have been found to be strongly associated with distant metastases within six ... read more
Stem Cell Therapy Drug May Protect Against Smoke-Related COPD Symptoms
July 5, 2018 — A drug used in stem cell therapy to treat certain cancers may also protect against cigarette smoke-induced lung ... read more
New Vulnerability in Deadly Form of Lung Cancer Discovered
July 3, 2018 — Researchers have discovered a new metabolic vulnerability in small cell lung cancer (SCLC) that can be targeted by existing drug ... read more
Metformin Reverses Established Lung Fibrosis
July 3, 2018 — Researchers have shown -- for the first time -- that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism. The finding is important because, despite ... read more
New Type of Lung Cancer
June 25, 2018 — Researchers have discovered a new kind of small-cell lung cancer (SCLC). The discovery paves the way for developing personalized medicine approaches to target this previously unnoticed form of the ... read more
New Target to Stop Cancer Growth Uncovered
June 21, 2018 — Researchers have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes -- tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor ... read more
When Push Comes to Shove: Airway Cells Propel Liver Cancer Spread to Lungs
June 1, 2018 — Researchers identified a crucial role for air sac-based scavenger blood cells, alveolar macrophages (AMs), in driving hepatocellular cancer metastasis in the lungs. AMs were found to be recruited by ... read more
Lung Cancer Risk Drops Substantially Within Five Years of Quitting, New Research Finds
May 29, 2018 — Just because you stopped smoking years ago doesn't mean you're out of the woods when it comes to developing lung cancer. That's the 'bad' news. The good news is your risk of ... read more
New Drugs Could Also Be Deployed Against Lung and Pancreatic Cancers
May 29, 2018 — A new anti-cancer drug may be effective against a wider range of cancers than previously thought. Using a mouse model and samples taken from cancer patients, a team has shown that a new class of ... read more
By Forming Clots in Tumors, Immune Cell Aids Lung Cancer's Spread
May 24, 2018 — Researchers report that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These immune cells, which normally help to build ... read more
Research Sheds Light on a Novel Disease Mechanism in Chronic Smokers
May 21, 2018 — Research suggests that an immune signalling protein called interleukin (IL)-26 is increased among chronic smokers with lung disease and this involvement reveals disease mechanisms of interest for ... read more
Nanoparticles Derived from Tea Leaves Destroy Lung Cancer Cells: Quantum Dots Have Great Potential
May 21, 2018 — Nanoparticles derived from tea leaves inhibit the growth of lung cancer cells, destroying up to 80 percent of them, new research has shown. The team made the discovery while they were testing out a ... read more
Particle Shows Promise for Treating the Deadliest Type of Breast Cancer
May 18, 2018 — Researchers have pinpointed a remedy to thwart a protein that helps the metastatic spread of breast cancer, a leading cause of death for ... read more
Method to Overcome False Positives in CT Imaging for Lung Cancer
May 15, 2018 — A team of researchers has identified a technology to address the problem of false positives in CT-based lung cancer ... read more
Better Equipped in the Fight Against Lung Cancer
May 14, 2018 — Lung cancer is the third most common type of cancer in Germany and the disease affects both men and women. However, immunotherapies are successful in only 20 percent of cases. Researchers have now ... read more
COPD-Associated Inflammation Halted in Model Experiment
May 3, 2018 — Chronic obstructive pulmonary disease, or COPD for short, is believed to be the third most common cause of death worldwide. However, because the underlying mechanism is still largely unknown, ... read more
New Approach to Treating Patients With Stage IV Wilms Tumor
Apr. 25, 2018 — A new study shows significantly improved survival rates for patients with stage IV Wilms tumors with lung ... read more
Can a Simple Blood Test Rule out Lung Cancer?
Apr. 17, 2018 — A blood test to measure the levels of two proteins in plasma that are common predictors of lung cancer was 98 percent effective in a multicenter clinical trial at distinguishing benign from malignant ... read more
Is Whole-Brain Radiation Still Best for Brain Metastases from Small-Cell Lung Cancer?
Apr. 16, 2018 — A new study compares outcomes of 5,752 small-cell lung cancer patients who received whole-brain radiation therapy (WBRT) with those of 200 patients who received stereotactic radiosurgery (SRS), ... read more
Combination Therapy Doubles Survival in Metastatic Lung Cancer
Apr. 16, 2018 — The immunotherapy drug pembrolizumab, combined with chemotherapy, doubles survival in patients with non-squamous non-small cell lung cancer (NSNSCLC) lacking genetic changes in the EGFR or ALK genes, ... read more
Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery
Apr. 16, 2018 — A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was ... read more
First-in-Human Clinical Trial of New Targeted Therapy Drug Reports Promising Responses for Multiple Cancers
Apr. 15, 2018 — A phase I, first-in-human study reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known ... read more
Nanoparticles for Lung Cancer Pass Next Test
Apr. 11, 2018 — Non-small cell lung cancer Nanoparticles pass the next stage of development in preclinical ... read more
New Immunotherapy for Lung Cancer Shows Promise of Success
Apr. 5, 2018 — In a groundbreaking development, results from a recent clinical trial to treat lung cancer show that a novel immunotherapy combination is surprisingly effective at controlling the disease's ... read more
Two-Pronged Approach Could Curb Many Cases of Lung Cancer
Apr. 2, 2018 — Lung cancer, a leading killer, has been hard to target with drugs. A team took a metabolic approach, looking at what lung tumor cells need to live and grow. When they removed these factors, tumor ... read more
Promising Drug May Stop Cancer-Causing Gene in Its Tracks
Mar. 26, 2018 — Scientists are testing a promising drug that may stop a gene associated with obesity from triggering breast and lung cancer, as well as prevent these cancers from ... read more
Metastatic Lymph Nodes Can Be the Source of Distant Metastases in Mouse Models of Cancer
Mar. 22, 2018 — A study finds that, in mouse models, cancer cells from metastatic lymph nodes can escape into the circulation by invading nodal blood vessels, leading to the development of metastases in other parts ... read more
Third-Hand Smoke Found to Increase Lung Cancer Risk in Mice
Mar. 9, 2018 — Researchers have identified third-hand smoke, the toxic residues that linger on indoor surfaces and in dust long after a cigarette has been extinguished, as a health hazard nearly 10 years ago. Now a ... read more
Mothers Who Smoke While Pregnant Contribute to the Severity of Asthma and Poor Lung Function in Their Children
Mar. 5, 2018 — Tobacco smoke exposure during pregnancy is worse for children with asthma than postnatal secondhand smoke exposure, according to a new study in the ... read more
RNA-Based Therapy Can Reduce Lung Cancer in Mouse Models, Study Finds
Feb. 28, 2018 — By turning down the activity of a specific RNA molecule, researchers have reduced lung tumors in mice by 40-50 percent. The results represent the tip of the iceberg in an extensive research project ... read more
Water in the Chest: New Findings on Pleural Effusion
Feb. 28, 2018 — Lung cancer patients are particularly susceptible to malignant pleural effusion, when fluid collects in the space between the lungs and the chest wall. Researchers have discovered a novel mechanism ... read more
Use of Immunotherapy to Treat Aggressive Colon Tumors
Feb. 14, 2018 — Researchers have developed a mouse model that mimics advanced human colon cancer. This model has allowed them to study the immune system response for the first ... read more
Lung Cancer Drug Resistance Explained by Computer Simulations
Feb. 12, 2018 — Scientists have used molecular simulations to understand resistance to osimertinib -- an anticancer drug used to treat types of lung ... read more
Molecular 'Magnets' Could Improve Cancer Immunotherapy
Feb. 8, 2018 — Chemicals that attract specialized immune cells toward tumors could be used to develop better immunotherapies for cancer patients, according to new research. Scientists have discovered that immune ... read more
Versatile Sensor Against Tumor Initiating Cells
Feb. 7, 2018 — Researchers have developed the first fluorescent sensor to visualize TICs. Functional in lung, central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer cell cultures, this ... read more
Small Molecule Plays a Big Role in Reducing Cancer's Spread
Jan. 31, 2018 — One small molecule that helps regulate gene expression plays a big role in keeping us safe from the machinations of cancer, scientists report. In human lung cancer cells, they have shown low levels ... read more
Making Milestones Against Non-Small Cell Lung Cancer
Jan. 24, 2018 — Progress concerning lung cancer has been enormous in the past 20 years, according to a new review from ... read more
Developing the VTX-1 Liquid Biopsy System: Fast and Label-Free Enrichment of Circulating Tumor Cells
Jan. 22, 2018 — A new platform could change the way cancer is diagnosed and treated by automating the isolation of circulating tumor cells (CTCs) directly from cancer patient ... read more
Can Mice Really Mirror Humans When It Comes to Cancer?
Jan. 18, 2018 — A new study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer. The findings reveal how mice can actually mimic human ... read more
Distorted View Amongst Smokers of When Deadly Damage Caused by Smoking Will Occur
Jan. 18, 2018 — Smokers have a distorted perception on when the onset of smoking-related conditions will occur, according to a new ... read more
New Study Offers Insights on Genetic Indicators of COPD Risk
Jan. 16, 2018 — Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who ... read more
A Kiss of Death for Prostate Cancer
Dec. 22, 2017 — Researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate ... read more
Even Smokers May Benefit from Targeted Lung Cancer Treatments
Dec. 13, 2017 — No matter a patient's smoking history, when a targetable genetic alteration is present, matching the alteration with the appropriate targeted therapy is associated with a survival benefit of 1.5 ... read more
Lung Cancers in Some African-Americans, European-Americans May Have Biological Differences
Dec. 1, 2017 — Differences in the genes expressed in non-small cell lung cancers (NSCLCs) from some African-Americans and European-Americans suggest that there are racial differences in the biology of NSCLC, which ... read more
Cancer Drug Leads to 'Drastic Decrease' in HIV Infection in Lung Cancer Patient
Nov. 30, 2017 — The first evidence that a cancer drug may be able to eradicate HIV-infected cells in humans has now been revealed by researchers. They report that while treating an HIV-infected lung cancer patient ... read more
Targeted Treatment Could Prevent Spread of Pancreatic Cancer, Heart Damage
Nov. 30, 2017 — A new targeted treatment could benefit patients with certain pancreatic tumors by preventing spread of the cancer and protecting their heart from damage -- a direct result of the tumor. Higher levels ... read more
Communication Between Lung Tumors, Bones Contributes to Tumor Progression
Nov. 30, 2017 — Investigators have identified a way in which a type of lung cancer co-opts a portion of the immune system to increase tumor ... read more
Two-Drug Combination May Boost Immunotherapy Responses in Lung Cancer Patients
Nov. 30, 2017 — A novel drug combination therapy that could prime nonsmall cell lung cancers to respond better to immunotherapy has been identified by researchers. These so-called epigenetic therapy drugs, used ... read more
'Aggressive' Surgery Is Best Treatment Option for Early Stage Lung Cancer
Nov. 30, 2017 — Patients with early stage lung cancer live longer when they receive a lobectomy -- the most common type of operation for the disease -- rather than a less extensive operation or radiation ... read more
Lower Lung Cancer Rates in Communities With Strong Smoke-Free Laws, Study Shows
Nov. 29, 2017 — Researchers studied the correlation between communities with strong smoke-free workplace laws and the number of new lung cancer diagnoses. Those communities have 8% fewer new cases than communities ... read more
Encouraging Oxygen's Assault on Iron May Offer New Way to Kill Lung Cancer Cells
Nov. 22, 2017 — Blocking the action of a key protein frees oxygen to damage iron-dependent proteins in lung and breast cancer cells, making them easier to kill, report ... read more
Study Questions Exclusion of Cancer Survivors from Trials
Nov. 22, 2017 — A quarter of newly diagnosed cancer patients 65 or older are survivors who had a prior cancer – often preventing them from participating in clinical trials, researchers have ... read more
Lung Cancer Triggers Pulmonary Hypertension
Nov. 22, 2017 — Nearly half of all advanced-stage lung cancer patients develop arterial pulmonary ... read more
Why Testicular Cancer Is So Responsive to Chemo
Nov. 14, 2017 — A major step has been taken toward answering a key question in cancer research: Why is testicular cancer so responsive to chemotherapy, even after it ... read more
Sensor for the Most Important Human Cancer Gene
Nov. 14, 2017 — The molecular smoke detector works like a TP53 sensor, which monitors the correct function of the gene. A non-functional TP53 gene is going to activate the sensor, which initiates cell ... read more
Cell Signaling Interaction May Prevent Key Step in Lung Cancer Progression, Study Shows
Nov. 9, 2017 — A novel cell signaling interaction that may prevent a key step in lung cancer progression, new findings ... read more
Deadly Lung Cancers Are Driven by Multiple Genetic Changes
Nov. 6, 2017 — A new study challenges the dogma in oncology that most cancers are caused by one dominant 'driver' mutation that can be treated in isolation with a single targeted drug. Instead, the new ... read more
Is Anticoagulant Warfarin Associated With Lower Risk of Cancer Incidence?
Nov. 6, 2017 — The use of the blood thinner warfarin was associated with a lower risk of new cancers in people over ... read more
FDG PET Shows Tumor DNA Levels in Blood Are Linked to NSCLC Aggressiveness
Nov. 6, 2017 — Researches have demonstrated a better way of determining the aggressiveness of tumors in patients with advanced non-small cell lung cancer (NSCLC). They used 18F-fluorodeoxyglucose (FDG) PET/CT ... read more
Three New Lung Cancer Genetic Biomarkers Identified
Oct. 28, 2017 — SNPs (single-nucleotide polymorphisms) are variations in our DNA that determine our susceptibility to developing some diseases. Using the largest genome-wide SNP-smoking interaction analysis reported ... read more
More Early Stage Lung Cancer Patients Survive the Disease
Oct. 26, 2017 — With the advancement of surgical and radiation therapy strategies for stage 1 non-small-cell lung cancer (NSCLC), more patients are being treated, resulting in higher survival rates, according to a ... read more
Tarloxitinib Puts Tumor-Seeking Tail on Anti-EGFR Drug to Precisely Target Lung Cancer
Oct. 24, 2017 — By pairing an anti-EGFR drug with a 'tail' that only activates the drug when it is very near tumor cells, tarloxitinib brings the drug to tumors while keeping concentrations safe in ... read more
To Vape or Not to Vape? Probably: Not to Vape
Oct. 20, 2017 — E-cigarettes appear to trigger unique immune responses as well as the same ones triggered by regular cigarettes, according to new ... read more
Lung Cancer Research Gets a Breath of Fresh Air
Oct. 10, 2017 — A research team has leveraged its human Organs-on-Chips technology to develop human orthotopic lung cancer models using human lung small airway and alveoli chips. The study models central aspects of ... read more
Gene That Influences Nicotine Dependence Identified
Oct. 10, 2017 — A DNA variant -- located in the DNMT3B gene and commonly found in people of European and African descent -- increases the likelihood of developing nicotine dependence, smoking heavily, and developing ... read more
Study Challenges Long-Standing Concept in Cancer Metabolism
Oct. 5, 2017 — Scientists have discovered that lactate provides a fuel for growing tumors, challenging a nearly century-old observation known as the Warburg ... read more
New System Finds and Targets Vulnerabilities in Lung Cancer Cells
Oct. 2, 2017 — Genetic changes that help lung cancer thrive also make it vulnerable to a promising experimental ... read more
'Epigenetic' Changes from Cigarette Smoke May Be First Step in Lung Cancer Development
Sep. 11, 2017 — Scientists say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called 'epigenetic' changes in the cells ... read more
Blood Tumor Markers May Warn When Lung Cancer Patients Are Progressing
Sep. 6, 2017 — A new study suggests that rather than screening for disease, blood tumor markers could be useful in monitoring therapeutic outcomes in those with already established ... read more
Blood Test Can Predict Early Lung Cancer Prognosis
Aug. 30, 2017 — Cancer cells obtained from a blood test may be able to predict how early-stage lung cancer patients will fare, a team of researchers has ... read more
Adding Radiation Treatments to Inoperable Lung Cancer Increases Survival by Up to One Year
Aug. 25, 2017 — Patients with unresectable, or inoperable, lung cancer are often given a dismal prognosis, with low rates of survival beyond a few years. Researchers exploring combination therapies have recently ... read more
New Virtual Model Reveals Details of Declining Lung Function in Mice
Aug. 24, 2017 — Scientists have developed a new virtual model of mouse lung function that illuminates the relative importance of different factors that contribute to lung changes accompanying chronic ... read more
Clear Link Between Heavy Vitamin B Intake and Lung Cancer
Aug. 22, 2017 — B vitamins are among the most popular supplements on the market in the United States. Some, like B6 and B12, are marketed and sold as products that can boost your energy. But a new study shows that ... read more
Blood Test Can Spot Tumor-Derived DNA in People With Early-Stage Cancers
Aug. 16, 2017 — In a bid to detect cancers early and in a noninvasive way, scientists report they have developed a test that spots tiny amounts of cancer-specific DNA in blood and have used it to accurately identify ... read more
New Strategy to Treat Aggressive Lung Cancer
Aug. 16, 2017 — Research on a novel therapeutic avenue for an aggressive and difficult to treat subgroup of lung cancer has now been shared in a new ... read more
Does Stronger Initial Response to Cancer Treatment Predict Longer Overall Survival?
Aug. 15, 2017 — It seems like such a simple question: Do patients whose tumors shrink more in response to targeted treatment go on to have better outcomes than patients whose tumors shrink less? But the implications ... read more
Blood Biopsy Test Reads Platelets to Detect Human Lung Cancer
Aug. 14, 2017 — Researchers have designed a different approach to the liquid biopsy. Rather than looking for evidence of cancer DNA or other biomarkers in the blood, their test (called thromboSeq) could diagnose ... read more
New Genes Discovered Regulating Brain Metastases in Lung Cancer Patients
Aug. 8, 2017 — Researchers set out to find which genes can regulate the cells that initiate brain metastases, and outline their findings in a new ... read more
How a Chemo Drug Can Help Cancer Spread from the Breast to the Lungs
Aug. 7, 2017 — The very same treatment that thwarts breast cancer has a dark side – it can fuel the spread of the disease to the lungs. Researchers found clues to why it happens, opening up the possibility of ... read more
Gold Specks Raise Hopes for Better Cancer Treatments
Aug. 7, 2017 — A tiny medical device containing gold specks could boost the effects of cancer medication and reduce its harm, research ... read more
Molecules That Could Help to Prevent the Development of Brain Tumors
Aug. 3, 2017 — Researchers have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the ... read more
A Braf Kinase-Inactive Mutant Induces Lung Adenocarcinoma
Aug. 2, 2017 — The initiating oncogenic event in half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies. Researchers have demonstrated that the ... read more
Breast Cancer Driver, HER2, in 3 Percent of Lung Cancers, Study Finds
July 27, 2017 — 24 of 920 patients (3 percent) with advanced-stage lung cancer had mutations in the gene HER2, which is linked to breast cancer, new research has ... read more
Smokers Who Undergo a CT Scan of Their Lungs More Likely to Quit
July 26, 2017 — New research has found that smokers who undergo a CT scan of their lungs are more likely to quit ... read more
COX-2 Inhibitors May Reverse IDO1-Mediated Immunosuppression in Some Cancers
July 21, 2017 — In preclinical studies, tumors that consitutively expressed the protein indoleamine 2,3-dioxygenase (IDO1) responded to the cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) and had improved ... read more
Concurrent Chemotherapy, Proton Therapy Improves Survival in Patients With Advanced Lung Cancer
July 20, 2017 — For patients with advanced, inoperable stage 3 lung cancer, concurrent chemotherapy and the specialized radiation treatment, proton therapy, offers improved survival compared to historical data for ... read more
Cause of Chemoresistance in Small Cell Lung Cancer Discovered
July 18, 2017 — Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally ... read more
Preclinical Results Support Entinostat's Role in Targeting the Tumor Microenvironment
July 11, 2017 — A preclinical report demonstrates that entinostat, Syndax's oral, Class-I histone deacetylase inhibitor, enhances the antitumor effect of PD-1 (programmed death receptor-1) blockade through the ... read more
Elevated Cancer Risk in Holocaust Survivors
July 10, 2017 — A new study indicates that survivors of the Holocaust have experienced a small but consistent increase in the risk of developing ... read more
Lung Cancer Screening Could Save Money as Well as Lives, Research Shows
June 29, 2017 — Lung cancer screening programs should target high-risk people and identify other tobacco-related conditions, suggests a new ... read more
First-Line Immunotherapy Treatment Can Improve Survival for Subset of Lung Cancer Patients
June 21, 2017 — Findings from a phase III clinical trial for advanced lung cancer patients could help oncologists better predict which patients are likely to receive the most benefit from immunotherapy as a ... read more
Discovery Could Guide Immunotherapy for Lung Cancer
June 19, 2017 — Scientists have discovered a new type of immune cell that could predict which lung cancer patients will benefit most from immunotherapy treatment, according to a new ... read more
Scientists May Have Found a New Way to Halt Lung Cancer Growth
June 14, 2017 — For the first time, scientists have uncovered a mechanism that makes lung cancer cells dependent on mutated versions of the gene p53, opening the potential for new, more effective ... read more
Largest Genome-Wide Study of Lung Cancer Susceptibility Identifies New Causes
June 13, 2017 — A huge study identified several new variants for lung cancer risk that will translate into improved understanding of the mechanisms involved in lung cancer ... read more
Hope for Better Lung Cancer Treatment on Horizon
June 13, 2017 — There is a better way to recruit the right participants for promising new anti-cancer drugs called FGFR (fibroblast growth factor receptor) inhibitors, which are being investigated for treating lung ... read more
Infants Born Preterm May Lack Key Lung Cells Later in Life
June 9, 2017 — Mice born into an oxygen-rich environment respond worse to the flu once fully grown due to an absence of certain lung cells, a discovery that provides a potential explanation for preterm ... read more
Standard Dosage for One Lung Cancer Treatment May Be Too High
June 6, 2017 — The customary pembrolizumab dose for treatment of metastatic non-small cell lung cancer may be higher than is needed for effective treatment, conclude ... read more
Time to Initiating Cancer Therapy Is Increasing, Associated With Worsening Survival
June 5, 2017 — After reviewing nearly 3.7 million patient records, researchers have shown that newly diagnosed cancer patients are having to wait longer to begin treatment, a delay that is associated with a ... read more
Alectinib Halts Lung Cancer Growth More Than a Year Longer Than Crizotinib
June 5, 2017 — Findings from a phase III clinical trial point to a more effective initial treatment for patients with ALK-positive non-small cell lung cancer (NSCLC). Compared to the current standard of care ... read more
Sweetening Connection Between Cancer and Sugar
May 26, 2017 — Scientists have found that some types of cancers have more of a sweet tooth than ... read more
Among All Cancers, Lung Cancer Appears to Put Patients at Greatest Suicide Risk
May 23, 2017 — A lung cancer diagnosis appears to put patients at the greatest risk of suicide when compared to the most common types of non-skin cancers, according to new ... read more
Using a Genetic Signature to Overcome Chemotherapy-Resistant Lung Cancer
May 23, 2017 — Patients with non-small cell lung cancer (NSCLC) often respond to standard chemotherapy, only to develop drug resistance later, and with fatal consequences. But what if doctors could identify those ... read more
New Strategy Reported to Combat Influenza and Speed Recovery
May 23, 2017 — Scientists have used a drug being developed to fight solid tumors to restore normal metabolism in flu-infected cells and reduce viral production without the threat of drug ... read more
Rise in Lung Adenocarcinoma Linked to 'Light' Cigarette Use
May 22, 2017 — So-called 'light' cigarettes have no health benefits to smokers and have likely contributed to the rise of a certain form of lung cancer that occurs deep in the lungs, new research has ... read more
How Cancer Cells Flood the Lung
May 19, 2017 — Lung cancer patients are particularly susceptible to malignant pleural effusion, when fluid collects in the space between the lungs and the chest wall. Researchers have discovered a novel mechanism ... read more
Number of Mutations in a Tumor Varies by Age and Type of Cancer
May 17, 2017 — The tumor mutation load, or TML, in a patient's cancer biopsy varied by age and the type of cancer, along with several other factors, a team of investigators has ... read more
Brigatinib First Drug to Offer Over 1-Year Control of ALK-Positive Lung Cancer Post-Crizotinib
May 17, 2017 — The FDA has approved brigatinib as a second-line therapy for ALK-positive non-small cell lung cancer, offering new hope for ... read more
Prototype Drug Uses Novel Mechanism to Treat Lung Cancers
May 16, 2017 — Lung cancer tumors were prevented in mice by a novel small molecule that directly activates a tumor suppressor protein, report researchers in a new ... read more
Biologists Identify Key Step in Lung Cancer Evolution
May 10, 2017 — Biologists have identified a major switch that occurs as lung adenomas transition to more aggressive adenocarcinomas -- and that blocking this switch prevents the transition. The findings suggest ... read more
Potential New Target for Cancer Treatment
May 5, 2017 — Inhibition of the enzyme RIOK1could stop the growth of tumors and the development of ... read more
Some Lung Cancer Patients Benefit from Immunotherapy Even After Disease Progression
May 4, 2017 — Some advanced lung cancer patients benefit from immunotherapy even after the disease has progressed as evaluated by standard criteria, according to new research. The findings pave the way for certain ... read more
White Blood Cell Count Predicts Response to Lung Cancer Immunotherapy
May 4, 2017 — White blood cell counts can predict whether or not lung cancer patients will benefit from immunotherapy, according to new ... read more
Atlases of Immune Cells Surrounding Tumors May Guide Immunotherapy
May 4, 2017 — Two independent studies have begun mapping the connections between and identities of the thousands of immune cells surrounding human tumors. One research group, looking at kidney cancer, found that ... read more
Immunotherapy Targets in Early-Stage Lung Cancer
May 4, 2017 — Immunotherapy, which has achieved remarkable results in late-stage lung cancer patients, can also hold great hope for newly diagnosed patients, cutting the deadly disease off before it has the chance ... read more
Men Need More Frequent Lung Cancer Screening Than Women
May 1, 2017 — Personalized screening strategies, such as a gender approach, could be a way to optimize results and allocate resources ... read more
Combination Therapy Could Provide New Treatment Option for Ovarian Cancer
May 1, 2017 — A new study identifies a potential test that may help select patients for whom combination therapy could be most ... read more
Overcoming Cancer Treatment Resistance
Apr. 27, 2017 — A collaborative team of researchers has proven the theory that, while resistance to targeted treatment in cancer is truly a moving target, there are opportunities to overcome the resistance that ... read more
Tracking Unstable Chromosomes Helps Predict Lung Cancer's Return
Apr. 26, 2017 — Scientists have found that unstable chromosomes within lung tumors increases the risk of cancer returning after surgery, and have used this new knowledge to detect relapse long before standard ... read more
T Cell Revival Correlates With Lung Cancer Response to PD-1 Immunotherapy
Apr. 24, 2017 — In lung cancer patients who were taking immunotherapy drugs targeting the PD-1 pathway, testing for CD8 T cell activation in their blood partially predicted whether their tumors would ... read more
Computer Program Developed to Diagnose and Locate Cancer from a Blood Sample
Mar. 24, 2017 — Researchers in the United States have developed a computer program that can simultaneously detect cancer and identify where in the body the cancer is located, from a patient's blood ... read more
Advanced Form of Proton Therapy Shows Promise for Treating Lung Cancer Recurrence
Mar. 17, 2017 — An advanced form of image-guided radiation therapy, known as intensity modulated proton therapy (IMPT), has shown early promise for the treatment of recurrent lung cancer, according to new ... read more
Biomarker Blood Test Shows Cancer Recurrence Months Before CT Scans
Mar. 16, 2017 — Results from a prospective clinical trial showed that a blood test looking at specific biomarkers was able to detect recurrences of lung cancer an average of six months before conventional imaging ... read more
Prevention and Prediction: Understanding How Lung Cancer Progresses
Mar. 16, 2017 — Treating the brain with a preventative course of radiation may help small cell lung cancer (SCLC) patients -- whose tumors often spread to their brain -- live longer, according to a new study. A ... read more
Hodgkin Lymphoma Survivors at High Risk of Second Cancers
Mar. 13, 2017 — Patients who are cured of Hodgkin lymphoma are at a high risk of developing a second type of cancer, particularly if they have a family history of the disease, a major new study ... read more
Reprogrammed Blood Vessels Promote Cancer Spread
Mar. 3, 2017 — Tumor cells use the bloodstream to spread in the body. To reach the blood, they first have to pass the wall of the vessel. Scientists have now identified a trick that the cancer cells use: They ... read more
Study Identifies How Cancer Cells May Develop Resistance to FGFR Inhibitors
Mar. 2, 2017 — A mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors has now been uncovered by investigators. The researchers also found ... read more
Cigarette Smoke Curbs Lung's Self-Healing
Mar. 2, 2017 — Smoke from cigarettes blocks self-healing processes in the lungs and consequently can lead to chronic obstructive pulmonary disease (COPD), reports an international team of ... read more
Liver Tumor Growth in Mice Slowed With New Chemo-Immunotherapy Treatment
Feb. 28, 2017 — Hepatocellular carcinoma is the most common form of liver cancer, but treatment options are limited and many patients are diagnosed in late stages when the disease can't be treated. Now, ... read more
Statins Do Not Benefit Patients With Lung Cancer, New Study Shows
Feb. 27, 2017 — Cholesterol-lowering drugs used alongside chemotherapy have no effect on treatment outcomes for lung cancer patients, according to a new ... read more
Limiting Lung Cancer's Spread, Growth in the Brain
Feb. 27, 2017 — Researchers analyzed RNA from patients with disease that was limited to the lungs as well as cancers that had ... read more
Resveratrol May Be an Effective Intervention for Lung Aging
Feb. 22, 2017 — Researchers demonstrate, for the first time that inhaled resveratrol treatments slow aging-related degenerative changes in mouse lung. Lung aging, characterized by airspace enlargement and decreasing ... read more
Scientists Identify Chain Reaction That Shields Breast Cancer Stem Cells from Chemotherapy
Feb. 22, 2017 — Working with human breast cancer cells and mice, researchers say they have identified a biochemical pathway that triggers the regrowth of breast cancer stem cells after ... read more
Death Rates from Cancer Will Fall Faster in Men Than in Women in Europe in 2017
Feb. 21, 2017 — Death rates from cancer in the European Union (EU) are falling faster in men than in women, according to the latest predictions for European cancer deaths in 2017. Compared with 2012, death rates in ... read more
E-Cigarettes Popular Among Smokers With Existing Illnesses
Feb. 21, 2017 — Current and former smokers suffering from illnesses like chronic lung or cardiovascular disease are more likely to use e-cigarettes, investigators ... read more
Protein Once Thought Exclusive to Neurons Helps Some Cancers Grow, Spread, Defy Death
Feb. 21, 2017 — How we think and fall in love are controlled by lightning-fast electrochemical signals across synapses, the dynamic spaces between nerve cells. Until now, nobody knew that cancer cells can repurpose ... read more
Spider Web of Cancer Proteins Reveals New Drug Possibilities
Feb. 17, 2017 — Scientists have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered 'undruggable.' This approach revealed new ... read more
Smoking Cessation Counseling Successful When Paired With Lung Cancer Screening
Feb. 14, 2017 — The first successful randomized trial of its kind provides preliminary evidence that telephone-based smoking cessation counseling given to smokers shortly after undergoing lung cancer screening can ... read more
'Achilles' Heel' of Key Anti-Cancer Protein
Feb. 13, 2017 — Researchers have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it into the cell nucleus. The research suggests that the loss of ... read more
Less Inclusive Criteria for Lung Cancer Screening Would Be Cost-Effective
Feb. 7, 2017 — Limiting lung cancer screening to high-risk former smokers may improve cost-effectiveness at a population level, according to a new study. An analysis of 576 computed tomography (CT) lung cancer ... read more
Scientists Discover Why Some Cancers May Not Respond to Immunotherapy
Feb. 6, 2017 — Scientists have discovered that people with cancers containing genetic mutations JAK1 or JAK2, which are known to prevent tumors from recognizing or receiving signals from T cells to stop growing, ... read more
Lung Cancer Screening Rates Remain Very Low Among Current and Former Smokers
Feb. 2, 2017 — Lung cancer screening rates remained very low and unchanged among eligible populations in 2015, despite recommendations that high risk current and former smokers be screened, report ... read more
Report Describes VHA Clinical Demonstration Project for Lung Cancer Screening
Jan. 30, 2017 — Implementing a comprehensive lung cancer screening program was challenging and complex according to a new article that describes a lung cancer demonstration project conducted at eight academic ... read more
Quick-and-Dirty DNA Repair Sets the Stage for Smoking-Related Lung Cancer
Jan. 26, 2017 — The stem cells that proliferate the most in response to damage caused by cigarette smoke repair their DNA using a process prone to errors, setting the stage for lung cancer, according to a new ... read more
Growing Tumors Put the Pressure on Nutrient-Supplying Blood Vessels
Jan. 26, 2017 — Mechanical pressure caused by cancer growth plays a key role in the development and distribution of blood vessels in tumors, according to a new ... read more
Lung Cancer Patients With Anxiety, Depression Die Sooner
Jan. 24, 2017 — Patients who experience anxiety and depression after being diagnosed with advanced lung cancer are more likely to die sooner, according to new ... read more
Tumor-Suppressing Protein Actually Promotes Cancer
Jan. 23, 2017 — The protein PHLDB3, thought to be a potential tumor suppressor, actually allows cancer cells to thrive in pancreatic, prostate, colon, breast, lung, and other common cancers, researchers have found. ... read more
Molecular Subgroups of Non-Small Cell Lung Cancer Predict Tumor Behavior, Reveal Treatment Targets
Jan. 20, 2017 — EGFR mutations is associated with a longer median overall survival (almost double) compared with those without EGFR mutations when treated with specific targeted agents, report ... read more
Researchers Identify Mechanism of Oncogene Action in Lung Cancer
Jan. 19, 2017 — Researchers have identified a genetic promoter of cancer that drives a major form of lung cancer. In a new paper, researchers provide genetic evidence that Ect2 drives lung adenocarcinoma tumor ... read more
Stem Cell 'Marking' Study Offers Alterative Hypothesis of Cancer Metastasis
Jan. 18, 2017 — Stem cells are among the most energetically activated, migratory and proliferative sub-populations of tumor cells, according to a new ... read more
New Research Holds Promise for Personalized Lung Cancer Treatments
Jan. 12, 2017 — New research has uncovered distinct types of tumors within small cell lung cancer that look and act differently from one another. Scientists also identified a targeted drug combination that worked ... read more
Older Lung Cancer Patients Face Significant Treatment Burden
Jan. 5, 2017 — Depending on the type of treatment older lung cancer patients receive, they can spend an average of one in three days interacting with the healthcare system in the first 60 days after surgery or ... read more
Cancers Evade Immunotherapy by 'Discarding the Evidence' of Tumor-Specific Mutations
Jan. 5, 2017 — Results of an initial study of tumors from patients with lung cancer or head and neck cancer suggest that the widespread acquired resistance to immunotherapy drugs known as checkpoint inhibitors may ... read more
Lung Cancer Patients May Benefit from Delayed Chemotherapy After Surgery
Jan. 5, 2017 — Patients with a common form of lung cancer may still benefit from delayed chemotherapy started up to four months after surgery, according to a team of ... read more
Lung-Sparing Surgery for Patients With Advanced Mesothelioma Results in Prolonged Survival, New Study Shows
Dec. 14, 2016 — Patients with advanced malignant pleural mesothelioma (MPM) treated with a combination of surgery to remove the cancer but save their lung, plus photodynamic therapy and chemotherapy, had a median ... read more
New Cancer Connection: Two Enzymes Work in Tandem to Spur Tumor Growth
Dec. 14, 2016 — Scientists have discovered that two enzymes previously linked independently with keeping cancer cells alive actually work in tandem to spur tumor ... read more
Immunotherapy Drug Gives Non-Small-Cell Lung Cancer Patients Extra Four Months of Life With Fewer Side Effects Compared to Chemotherapy
Dec. 13, 2016 — Patients with advanced non-small-cell lung cancer survive four months longer with fewer side effects on an immunotherapy drug called atezolizumab compared to chemotherapy, according to a phase 3 ... read more
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