Pages

Showing posts with label Methotrexate. Show all posts
Showing posts with label Methotrexate. Show all posts

Thursday, 1 May 2014

'Thor's vine' could ease rheumatoid arthritis

Chinese herb dubbed 'Thor's vine' could ease rheumatoid arthritis 

Sunday April 27, 2014
Extracts of the lei gong teng herb have already fired the interest of drug laboratories as they contain hundreds of compounds, including intriguing molecules called diterpenoids, which are believed to ease inflammation and immune response. – AFP
Extracts of the lei gong teng herb have already fired the interest of drug laboratories as they contain hundreds of compounds, including intriguing molecules called diterpenoids, which are believed to ease inflammation and immune response. – AFP

China's lei gong teng or "Thunder God vine" has apparently beaten conventional scientific medicine at treating a potentially crippling autoimmune disease.
A Chinese herb called “thunder god vine” works better than a widely-prescribed pharmaceutical drug at easing rheumatoid arthritis, a study published recently reported. The herb has long been used in China to treat this potentially crippling autoimmune disease, which typically strikes hand and foot joints.
It is known in Mandarin as lei gong teng, and to botanists as Tripterygium wilfordii Hook F. Extracts of the herb have already fired the interest of drug laboratories as they contain hundreds of compounds, including intriguing molecules called diterpenoids, which are believed to ease inflammation and immune response.
In a study published in the British journal BMJ Open, Chinese researchers recruited 207 patients with rheumatoid arthritis and gave them either the herb; the drug methotrexate; or a combination of the two. After six months, the patients were given a doctor’s assessment, and were asked if they felt any change.
The benchmark for improvement is called the ACR 50 – named after the American College of Rheumatology – which indicates a 50% improvement in the tally of tender or swollen joints, and other criteria such as pain and disability.
Of the 174 who completed the trial, 55% of those on the herb attained ACR 50, compared to 46% among those treated with methotrexate alone. But the biggest gain was among the group which took the herb-methotrexate combination: nearly 77% of them achieved the ACR 50 measure of improvement.
Previous – but small-scale – trials involving thunder god vine have found it scored well against a harmless lookalike placebo, and an anti-inflammatory called sulfasalazine. But some of that research also flagged potential side effects from the herb.
The new study said that side effects this time were roughly similar among the herb and methodrexate users, being mainly gastrointestinal upsets. Among the herb group, some of the women experienced irregular menstruation.
The investigation, led by Xuan Zhang, a rheumatologist at the Peking Union Medical College Hospital in Beijing, acknowledged several limitations. One was that the doctors who treated the patients, and the patients themselves, knew what medication was being taken, although outside assessors were brought in to verify the results.
Another was that the trial was too short to see if the herb arrested progression of the disease, rather than eased the symptoms. A third was that the dose of methotrexate was limited to 12.5 milligrams a week. “This is standard in Asia, although it is common in the West to use higher doses,” the paper said. – AFP Relaxnews
http://www.thestar.com.my/Lifestyle/Health/2014/04/27/Chinese-herb-dubbed-Thors-vine-could-ease-rheumatoid-arthritis/

Monday, 16 January 2012

Treat Your Liver with Love.....

Treat Your Liver with Love: Improve Your Energy, Memory and More

The liver is one of the largest, busiest, most important organs in the body. People generally give little thought to liver health... and that’s a mistake.

Poor liver function can lead to a wide range of physical and mental health problems—from allergies and bad breath to bloating and chronic fatigue, food sensitivities, memory problems and migraines, to name just a few.

In naturopathic circles, we have a saying, "If you aren’t sure what a patient needs, treat the liver." This approach is in step with the great healing practices of old, including Ayurvedic and traditional Chinese medicine, which emphasize the importance of a healthy liver for optimal wellness. Here are steps you can take to protect, detoxify and heal your liver—and the dangerous "treatments" some misguided people try that actually do more harm than good.

WHAT DOES YOUR LIVER DO?

Roughly one-quarter of the blood in the body flows through the liver every minute. Oxygen-rich blood is delivered directly from the heart... and nutrient-rich blood travels nonstop from the intestines. Liver cells called hepatocytes handle more tasks than any other cells in the body. They also contain high concentrations of mitochondria, the energy-producing parts of the cells. The liver affects numerous bodily functions...

Digestion. Before the small intestine can absorb fats—including fat-soluble vitamins A, D, E and K—the fats must be emulsified (suspended in fluid). To do that, the liver produces up to 27 ounces a day of the digestive fluid bile. Some bile goes directly to the small intestine to meet immediate needs, and the rest is stored in the gall bladder.

The liver metabolizes food, turning it into fuel called glucose... and converts glucose into glycogen and stores it as a fuel reserve for times when blood glucose runs low. The liver also transforms vitamins and minerals into forms the body can use... stores reserves of numerous nutrients... and breaks down various substances into waste products, which the body then excretes.

Detoxification. Toxic substances, such as alcohol, and prescription and nonprescription medications (which some people cannot properly metabolize for genetic reasons), meet their ultimate end in the liver. How: First the liver filters toxins from the blood... then changes the toxins’ chemical structures to make them more water-soluble so that they can be excreted through urine and stool. The various enzymatic processes through which the liver accomplishes these tasks are called detoxification pathways.

Circulation. The liver produces components that allow blood to clot, plus proteins to dissolve clots that are no longer needed... breaks down old red blood cells, freeing the iron they contain so that it can be reused... and produces albumin, a blood protein that transports certain minerals and medications throughout the body.

Hormone activity. The liver synthesizes cholesterol, which is necessary for the production of hormones... and produces carrier proteins that transport hormones via the blood.

Immune function. The liver produces immune cells that help remove bacteria from the blood.

IF THE LIVER IS UNHEALTHY

When the liver operates suboptimally, it is called "sluggish," meaning it cannot detoxify substances rapidly or thoroughly enough for them to be efficiently excreted. Consequently, lingering toxins exit the liver and migrate to other areas of the body, producing free radicals—unstable molecules that can damage body tissues. Eventually, the body tucks the toxins into fat tissue and cells of the brain and central nervous system. These toxins may be slowly released into the blood and contribute to many chronic health problems, including arthritis, chronic fatigue and poor memory. A sluggish liver also may affect blood flow—one possible reason why liver problems are linked to cold hands and feet, migraine and nearsightedness.

Sluggish liver is not recognized in the world of conventional medicine, so it often goes undiagnosed and untreated. One reason: Blood tests intended to detect the elevated liver enzymes that signal poor liver function generally do not show marked abnormalities until liver impairment is severe.

Many conventional doctors dismiss mildly elevated liver enzyme levels as unimportant and therefore do not recommend follow-up testing or treatment. However, small elevations can indeed indicate liver damage. Evidence: In a study in the British Medical Journal, researchers followed up on abnormal liver enzyme test results in 873 patients. They found that physicians ordered further testing and/or treatment for 531 patients who had known liver disease. Among the remaining 342 patients, doctors’ notes suggested that 157 merited further investigation—but 91 of those patients were not sent for follow-up testing. When the researchers ordered additional tests on all 157 patients, 62% of them had an identifiable diagnosis—including contagious viral hepatitis or other chronic liver diseases that required hospitalization.

My approach: When initial tests show elevated liver enzyme levels, I work with the patient to address possible contributing factors, including diet, pharmaceutical use and toxin exposure... and I prescribe natural supplements that enhance liver function. After four to six weeks of this protocol, I retest to see whether the problem has been corrected.

DETOXIFICATION: WHAT HURTS, WHAT HELPS

The following protocol promotes liver health and generally is beneficial for everyone. Unless noted, supplements are sold at health-food stores, are safe and have no side effects (as a general precaution, do not use if you are pregnant or breast-feeding).

DO NOT try "liver flushes." Currently popular is a one-to-three-day fast during which the person consumes only a mixture of water, lime juice, maple syrup and cayenne pepper (or a similar concoction). I strongly advise against this. First, flushes don’t work. It takes more than a few days to clear out toxins, reestablish normal bile flow and heal liver cells. Second, flushes can be dangerous, especially for people with nutritional deficiencies, gallstones or severe chemical toxicities. Risks include nausea, vomiting, diarrhea, headache, fatigue and muscle aches.

DO follow a detox diet. Most plant foods contain phytochemicals that aid in detoxification. Aim for two or three servings per day of foods rich in the following phytochemicals...
  • Allium—from garlic, onions, chives.
  • Chlorophyll—from spinach, chard, turnip greens.
  • Ellagic acid—from red grapes, raspberries, blackberries.
  • Gallic acid—from mangoes, rhubarb, soy foods, green and black teas.
  • Glucosinolates and indoles—from cruciferous vegetables, such as broccoli, kale, Brussels sprouts.
  • Isothiocyanates—from horseradish and cruciferous vegetables.
  • Limonene—from citrus fruits and peels.
  • Sulforaphane—from broccoli sprouts and cruciferous vegetables.
Also helpful: Curcumin, found in the spice turmeric. To incorporate it into your diet, add turmeric liberally while cooking.

Important: Avoid—or use sparingly—foods that stress the liver, including alcohol, caffeine, sugar, artificial sweeteners, saturated fats (found in meats and nonskim dairy foods) and trans fats (such as hydrogenated vegetable oils and shortening).

DO hydrate. Each day, drink 80 ounces of water that has been purified through a faucet-mounted or pitcher-style charcoal filter or a reverse-osmosis filter (installed on your home’s main waterline).

DO steer clear of toxins. When possible, avoid secondhand smoke... pesticides... automobile exhaust... fumes from paints, glues, fire retardants and cleansers... arsenic (in unpurified water, contaminated shellfish and nonorganic chicken)... lead (in old pipes, paints, crystal and dishware)... and mercury (in some vaccines, amalgam dental fillings and some seafoods, such as swordfish and tuna).

DO use healing roots and herbs. Beetroot, dandelion root, Oregon grape root, wild yam, wormwood and milk thistle stimulate production of bile and its flow from the liver. Convenient: A formula that combines liver-supporting herbs, such as Gaia Herbs Liver Health (888-917-8269, www.GaiaHerbs.com) or Solaray Liver Blend (800-669-8877, www.Nutraceutical.com). Follow dosage instructions on labels—typically one capsule before each meal. For a general liver tune-up, I advise all adults to take an herbal liver formula for one month per year. If your liver enzyme levels are elevated, take it for six weeks or until enzymes normalize. If you have chronic hepatitis, continue indefinitely.

DO take supplements that support detoxification pathways. I advise everyone to take a multivitamin/mineral daily, continuing indefinitely. In addition, I recommend the following supplements. Take them for one month per year (the same month in which you use the liver support formula, described above)... or indefinitely if you have chronic liver disease or frequent exposure to any of the toxins described above.
  • N-acetylcysteine (NAC), an amino acid derivative, at 250 mg twice daily.
  • Vitamin C at 500 mg twice daily (in addition to the vitamin C in your multivitamin).
  • Chlorella, a green algae, taken as directed on the label. Good brand to try: Sun Chlorella (800-829-2828, www.SunChlorellaUsa.com).
DO limit medication. Avoid unnecessary prescription and nonprescription drugs—and never use higher-than-recommended doses. Certain drugs can harm the liver by creating the following problems...
  • Liver inflammation—from more than 100 products that contain the painkiller and fever reducer acetaminophen (Tylenol).
  • Bile flow impairment—from birth control pills, the antibiotic erythromycin, the psychiatric drug chlorpromazine (Thorazine) and anabolic steroids.
  • Elevated liver enzyme levels and possible liver failure—from cholesterol-lowering statins.
  • Drug-induced hepatitis—from statin drugs and nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil) and naproxen (Aleve).
  • Liver toxicity—from the arrhythmia drug amiodarone (Cordarone, Pacerone) or the rheumatoid arthritis and cancer drug methotrexate (Rheumatrex, Trexall).
DO reduce stress. Every day, practice a relaxation technique, such as meditation or deep breathing. Regular exercise also alleviates stress.

When your liver is once again operating optimally, you will be amazed at how much better you feel.
The more symptoms you have, the more important it is for you to adhere to the recommendations in this article and to seek help from a holistic doctor. In addition to the symptoms mentioned above, a poorly functioning liver could contribute to numerous ailments, including blood sugar regulation problems (hypoglycemia, prediabetes, diabetes)... body odor that is very strong... cold hands and feet... depression... frequent diarrhea... fibrocystic breasts... gassiness... joint and/or muscle pain... irregular menstrual periods... nasal congestion... prostate enlargement or prostate cancer... skin rashes... and weight gain.

Mark A. Stengler, NMD, is a naturopathic medical doctor and leading authority on the practice of alternative and integrated medicine. Dr. Stengler is author of the Bottom Line Natural Healing newsletter, author of The Natural Physician’s Healing Therapies (Bottom Line Books), founder and medical director of the Stengler Center for Integrative Medicine in Encinitas, California, and adjunct associate clinical professor at the National College of Natural Medicine in Portland, Oregon. www.DrStengler.com


http://highenergyforlife.com

Wednesday, 21 December 2011

Teeth And Gums Affect The Heart And Nerves

December 5, 2011 by




We’ve previously discussed how cancer can be related to dental infections. But the fact that your teeth connect via your nerves to the organs, muscles and body tissues means that heart and gland problems can also originate from dental pathogens. So if you want your heart and glands to be healthy, check the health of your mouth first.

Neurological Control

I recently attended an eye-opening conference in Las Vegas at the International Association for Oral and Medical Toxicology (IAOMT). I learned your teeth act as circuit breakers to your spine, and they exert profound neurological control over the rest of your body.

This emerging field offers ways to reverse chronic illness of many types, along with cancer. Your teeth connect via your nerves to every part of your body. In fact, 46 percent of the motor and sensory nerves of your brain’s cerebral cortex are interconnected to your mouth and face. Additionally, your teeth develop from the same embryological neural crest tissue as the sympathetic and parasympathetic nervous system. These connections explain why we see such profound reversal of disease when hidden dental pathology is corrected.

What’s more, the lymphatic vessels of the teeth drain through the same lymphatic nodes that the thyroid gland does. Consequently, all the dental infections or materials that leak out from your teeth ultimately pass through the thyroid gland. This drainage could be a cause for so much of thyroid dysfunction we see in modern medicine today. Any problem in the mouth migrates to the thyroid gland. Even vaccines that children receive can become trapped in the thyroid gland.

Heart Failure

Holistic and biological dentist Gerald Smith, D.D.S., has discussed his discoveries of the dental-whole body connection at IAOMT gatherings. One of his patients from Seoul, Korea, suffered congestive heart failure, which completely disappeared after Smith removed a strep infection where a lower molar had been extracted 10 years earlier. A patient with emphysema had been on steroids for more than a year. After Smith removed infection from a previous tooth extraction 15 years earlier, the patient’s emphysema completely disappeared.

Another woman endured 34 years of severe rheumatoid arthritis that had begun a year after she had a root canal of an upper incisor at age 29. She was on methotrexate, prednisone and the very expensive drug Enbrel®. After the strep infection in her root canal was removed, she was completely free of symptoms. You can view other, similar, case histories at www.dentalwholebodyconnection.com.

Dysfunctional Triggers

According to the clinical evidence presented by Smith, every time you have a problem with a tooth, it can trigger dysfunction in the related organs of the body. And, in the other direction, organ problems can set off mouth problems. For example, if the adrenal glands are adversely affected by a toxic metal like cadmium, mercury or aluminum, it can lead to pain in a lower molar. You can watch a video of Smith’s presentation here.

At the IAOMT conference, Dr. Alfred C. Fonder showed that in just one hour after a half millimeter support was placed on a second molar, a patient’s chronic scoliosis and kyphosis showed radiographic reversal which were revealed in before-and-after X-rays.

Moreover, my friend and colleague, Wendell Robertson, D.D.S., of Springville, Utah, has shared some incredible findings he has discovered. (He specializes in biological dentistry and safe amalgam removal.) I spoke with one of his patients, a 62-year-old woman who shared her experience with me.

The woman had suffered with temporal mandibular joint (TMJ) pain for years, which she attributed to a head injury that occurred while she was in high school.

Organ Problems

The patient explained to me that in July 2010, she made two visits to the emergency room for heart arrhythmia and was in the intensive care unit for two nights during her evaluation. The medical staff could find nothing clinically amiss to explain her problem.

Later, in August 2010, she went to her chiropractor with pain in her left jaw, down her left arm and into the left half of her left chest. He sent her to the local hospital emergency room; but even after extensive work up of her heart, gall bladder and intestines (the total hospital bill was more than $29,000), she was sent home without a diagnosis or any suggested new treatments.

In December of that year, she went to Robertson for a routine teeth-cleaning appointment. While she was in the waiting room, she read about the effects that infected teeth can have on body organs. She immediately asked for extractions of the teeth that had received root canals.

While performing the dental work, Robertson also found infection in a former third molar socket. The woman says that during the extraction procedure, while she was in the dentist’s chair, the pain left her neck, arm and chest. Since then, she has enjoyed increased strength, no heart arrhythmias and no TMJ problems.

In my next article, I’ll sum up the connections between the teeth and the rest of the body so you can more knowledgeably assess how the state of your teeth and gums may be affecting your health.

Discover your best health.

Respectfully,
Michael Cutler, M.D.
Author, Easy Health Options

easyhealthoptions.com

Wednesday, 19 October 2011

Possible Interactions with: Vitamin B9 (Folic Acid)

Interactions:

If you are currently being treated with any of the following medications, you should not use folic acid supplements without first talking to your health care provider.

Antibiotics, Tetracycline -- Folic acid should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. Folic acid either alone or in combination with other B vitamins should be taken at different times from tetracycline. (All vitamin B complex supplements act in this way and should therefore be taken at different times from tetracycline.)

Drugs That Lower Levels of Folic Acid -- These drugs may interfere with the body's absorption of folate, and may mean you need to take a folic acid supplement. Talk to your doctor first.
  • Antacids, H2 blockers, proton pump inhibitors
  • Bile acid sequestrants
  • Carbamazepine
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Sulfasalazine
  • Triamterene
When taken for long periods of time, these medications, as well as other anti-inflammatory medicines, can increase the body's need for folic acid.

Birth Control Medications, Anticonvulsants, and Cholesterol-lowering Medications -- Birth control medications, anticonvulsants for seizures (namely, phenytoin and carbamazapine), and cholesterol-lowering medications (namely, bile acid sequestrants, including cholestyramine, colestipol, and colesevelam) may reduce the levels of folic acid in the blood as well as the body's ability to use this vitamin. Extra folate when taking any of these medications may be recommended by your health care provider. When taking bile acid sequestrants for cholesterol, you should take folate at a different time of day.

Methotrexate -- Methotrexate, a medication used to treat cancer, rheumatoid arthritis (RA), and psoriasis, reduces the amount of folic acid in the body. People who take methotrexate for RA or psoriasis may be prescribed higher doses of folic acid, which helps reduce the side effects of methotrexate. People taking methotrexate for cancer, however, should avoid folic acid supplements unless directed by their doctor, because folic acid may interfere with methotrexate's effects on cancer.

Drug Interactions:

Acetaminophen-containing MedicationsAnticonvulsantsAspirinBirth Control MedicationsCholesterol-lowering MedicationsCimetidineIbuprofenMetformin-containing MedicationsPentobarbitalPhenobarbitalSulfasalazineTetracycline

Alternative Names:

Folacin; Folate; Folic Acid; Vitamin B9 (Folic Acid)
  • Reviewed last on: 9/6/2007
  • Steven D. Ehrlich, N.M.D., private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network.

http://www.umm.edu/altmed/articles/vitamin-b9-000993.htm