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Showing posts with label Prostate Health. Show all posts
Showing posts with label Prostate Health. Show all posts

Thursday, 2 December 2021

Statin use affects prostate cancer screening results

 

Summary:
Prostate cancer screening results differ in men taking cholesterol-lowering statin drugs compared with non-users, a study finds. In statin users, screening did not increase the incidence of prostate cancer as it did in other men.
Date:
November 29, 2021
Source:
Tampere University

FULL STORY

Prostate cancer screening results differ in men taking cholesterol-lowering statin drugs compared with non-users, a study conducted at Tampere University in Finland finds. In statin users, screening did not increase the incidence of prostate cancer as it did in other men.

The study found the clearest difference in low-risk cancer, which is often overdiagnosed due to screening. The number of low-risk tumours found in screening was significantly lower in statin users. However, statin use caused no difference in the detection of high-risk cancers. In the screened group, prostate cancer mortality was slightly lower than in the unscreened group, both in men taking statins and other men.

"The study provides significant new information because statin use is very common and the effects of prostate cancer screening have not been previously evaluated in relation to statin use," says Professor Teemu Murtola from the Faculty of Medicine and Health Technology at Tampere University.

The study was published in the JAMA Oncology journal on 24 November 2021.

The findings may be explained by the fact that statin use improves the accuracy of prostate cancer screening. This means that screening detects dangerous types of cancer in these men as well as in others, but in statin users, there is less of the so-called overdiagnosis, which means the detection of low-risk prostate cancers that do not pose a health threat due to their very slow growth rate.

Another possible explanation could be that men who use statins are a select group who already actively use health services and have had PSA tests outside systematic screening. In those cases, the additional screening done in the study does not have such a great impact.

The study was based on data from the Finnish Prostate Cancer Screening Trial which started in 1996-1999. A total of about 80,000 men were included in the study, of whom just under 32,000 were screened with the PSA test every four years. The project was carried out jointly by Tampere University and the University of Helsinki and the Helsinki and Tampere University Hospitals.


Story Source:

Materials provided by Tampere UniversityNote: Content may be edited for style and length.


Journal Reference:

  1. Arla Vettenranta, Teemu J. Murtola, Jani Raitanen, Paavo Raittinen, Kirsi Talala, Kimmo Taari, Ulf-HÃ¥kan Stenman, Teuvo L. J. Tammela, Anssi Auvinen. Outcomes of Screening for Prostate Cancer Among Men Who Use StatinsJAMA Oncology, 2021; DOI: 10.1001/jamaoncol.2021.5672

Cite This Page:

Tampere University. "Statin use affects prostate cancer screening results." ScienceDaily. ScienceDaily, 29 November 2021. <www.sciencedaily.com/releases/2021/11/211129105542.htm>.




RELATED STORIES

Thursday, 21 February 2019

Look out for these things in your wee - they might be signs of cancer

Check for these signs and symptoms of prostate cancer

By
  • 10:49, 19 FEB 2019



Prostate cancer is the most common cancer in men in the UK.

The causes of it are unknown, but as you get older, your chances of developing it increase.
The terrifying statistic is that one in two people in the UK will get cancer at some point in their lives.
And so it's extremely important that you notice the signs of cancer early.

Prostate cancer develops slowly, and many men don't see any symptoms for years, reports the Mirror.
It isn't until the prostate becomes large enough to affect the tube which carries urine out of the bladder and out of the penis that some of the tell-tell signs start to appear.
According to the NHS, there are seven things all men should be checking for in their wee which could be a tell-tell sign of the disease.
They are:
  • Needing to pee more frequently, often during the night
  • Needing to rush to the toilet
  • Difficulty in starting to pee (hesitancy)
  • Straining or taking a long time while peeing
  • Weak flow
  • Feeling that your bladder has not emptied fully
  • Blood in urine or semen
There are a number of tests which can help diagnose prostate cancer, all of which your doctor should be able to arrange.
They are a blood test, a physical prostate examination, and MRI or a biopsy.
If the disease is caught early it can be treated through radiotherapy or surgery to remove it.
However if it isn't caught until later it can spread to other parts of the body.
Experts don't know why, but prostate cancer is more common in men of African-Caribbean or African descent and Asian men are less likely to be affected.

Monday, 31 December 2018

Prostate hope for millions of over-50s: Radical five-minute 'steaming' treatment cures embarrassing condition WITHOUT surgery

  • Two million men in Britain have been diagnosed with an enlarged prostate 
  • Problem commonly causes repetitive night-time visits to the bathroom
  • The five-minute procedure to shrink the gland cuts the need for surgery
  • Health watchdogs are expected to give it the green light for routine NHS use

A radical new steam treatment could offer hope to millions of middle-aged men who suffer with an enlarged prostate.
The five-minute procedure to shrink the gland cuts the need for surgery and comes with minimal side effects.
Health watchdogs are expected to give it the green light for routine NHS use tomorrow.
Two million men in Britain have been diagnosed with an enlarged prostate – but it is thought to affect as many as half of all men over the age of 50, and 60 per cent of those over 60.
The problem commonly causes repetitive night-time visits to the bathroom, but many men find that having rushed out of bed, they cannot urinate after all.
The new treatment – which involves injecting an enlarged prostate with jets of steam – avoids the severe impacts of invasive operations that can often spell an early end to a man's sex life.
Scroll down for video 
The five-minute procedure to shrink the gland cuts the need for surgery and comes with minimal side effects. Pictured: How the treatment works
The five-minute procedure to shrink the gland cuts the need for surgery and comes with minimal side effects. Pictured: How the treatment works
An enlarged prostate is not linked to cancer and does not increase the risk of getting prostate cancer – yet the symptoms can be similar, so most men with the problem are tested to make sure their prostate is not cancerous.
It is caused by benign prostatic hyperplasia, in which an overgrown prostate presses into the bladder and blocks the urethra, the vessel through which it empties.
In extreme cases, men find they cannot urinate, leading to a dangerous build-up of toxins that can cause severe kidney problems. Every year more than 18,000 men undergo a painful operation to relieve the problem, which involves removing part of the prostate. However the vast majority with the condition avoid surgery because of fears over side effects.
While the operation – called transurethral resection of the prostate (TURP) – is effective, it can lead to loss of sexual function, bleeding and incontinence.
The steam treatment, called Rezum, simply shrinks the prostate with few side effects. The procedure, performed under local anaesthetic and sedation, involves injecting nine-second bursts of steam into the prostate, via a thin tube inserted into the urethra.
The steam is injected at 1cm intervals, killing enough prostate tissue to shrink the enlarged gland.
Surgeons at Imperial College Healthcare NHS Trust in London and Hampshire Hospitals NHS Foundation Trust have trialled the procedure on 150 men, with remarkable results.
Professor Hashim Ahmed, a consultant urological surgeon at Imperial, said other hospitals are poised to roll out the treatment as soon as they get the okay from health watchdog NICE.

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An enlarged prostate is not linked to cancer and does not increase the risk of getting prostate cancer ¿ yet the symptoms can be similar, so most men with the problem are tested to make sure their prostate is not cancerous 
An enlarged prostate is not linked to cancer and does not increase the risk of getting prostate cancer – yet the symptoms can be similar, so most men with the problem are tested to make sure their prostate is not cancerous 
'A huge group of men could benefit from this treatment,' he said. Experts believe it will in time completely replace TURP. But they also think many more men who until now have been reluctant to undergo an operation will take up the steam option. Professor Ahmed said: 'There is a large group of men who are so worried about the side effects of an operation that they are suffering without treatment, or relying on drugs and their side effects.'
He said the Rezum treatment – which is made by US firm NxThera – could save the NHS money.
'It frees up huge NHS resources because you need much less theatre time,' he said. 'You are also opening up tens of thousands of days of bed occupation around the country.'
Conventional TURP operations take 90 minutes in surgery and an average of three days of recovery time in an NHS bed. The Rezum treatment, in comparison, takes just five minutes.
Professor Ahmed said: 'From arriving in theatre to leaving again is taking no more than 15 minutes. And it is a day case – there is no need to take an NHS bed.' The Rezum procedure costs the NHS about £2,000 – roughly the same as TURP – but taking into account theatre time and no need for a bed it could save the health service millions. Privately it costs about £5,000, compared to £6,000 for TURP.
Professor Ahmed and Professor Richard Hindley of Hampshire Hospitals, who performed the first Rezum procedure in Basingstoke last year, have compiled the results of their first 80 patients to receive the treatment.
On average their patients' prostates shrunk by 36 per cent – a comparable result to TURP. But remarkably, the side effects have been minimal.
Professor Ahmed said: 'We have seen zero incontinence and virtually zero impotence. And you get a quicker recover, meaning you can get back to work and get on with your life.'
Two million men in Britain have been diagnosed with an enlarged prostate ¿ but it is thought to affect as many as half of all men over the age of 50, and 60 per cent of those over 60 
Two million men in Britain have been diagnosed with an enlarged prostate – but it is thought to affect as many as half of all men over the age of 50, and 60 per cent of those over 60 
For patients who receive TURP, in comparison, roughly 10 per cent are left with erectile problems and 2 per cent have permanent urinary incontinence.
Roughly 65 per cent are also left with ejaculation problems – for Rezum it is about 5 per cent.
Professor Ahmed stressed there are some disadvantages of the steam treatment. He said: 'It is not instant – it might take three to eight weeks to see the benefit, it is a slow burn.'
The technology may also be unsuitable for men with the largest prostates – who would be better off having a high-tech laser surgery treatment.
Rezum is the latest in a series of non-surgical options for enlarged prostates to emerge in the last year.
Another treatment involves blocking the blood supply to the prostate by injecting tiny plastic beads into an artery.
Professor Hindley, who does his academic work at the University of Winchester, added: 'This could be a game-changer for the NHS. You can do five or six cases in half a day.'
 
'Steaming operation has helped me sleep': Patient who suffered from condition for two decades now has relief 
For the last two decades Chris Allard has put up with a medical complaint that affects most men his age.
‘About 20 years ago I started noticing I had joined the “first in last out” club at the toilet,’ the 71-year-old said. ‘But I just put up with it.’
Things got so bad he was waking up three times a night to go to the loo. Mr Allard, who ran a kitchen and bathroom fitting business until retirement, suffered from an enlarged prostate. 
For the last two decades Chris Allard (pictured with his wife Chris) has put up with a medical complaint that affects most men his age. But after the treatment, his 'symptoms have dramatically reduced'
For the last two decades Chris Allard (pictured with his wife Chris) has put up with a medical complaint that affects most men his age. But after the treatment, his 'symptoms have dramatically reduced'
A decade ago he was given drugs to counter the problem – but stopped taking them because they made him drowsy. Eventually things got so bad he needed treatment.
His doctor proposed surgery, but Mr Allard was concerned about possible side effects on sexual performance and incontinence.
He approached Hashing Ahmed, a surgeon at Charing Cross Hospital, who was trialling the Rezum therapy, in which steam is injected into the prostate.
‘I was sedated and I felt no physical discomfort at all,’ he said. ‘The symptoms have dramatically reduced. I don’t need to go to the toilet as often… And that really helps with my sleep.’  

Monday, 19 June 2017

Family connection warning over prostate cancer risk

Updated: 
The same study found that more than half of men in the general population are blind to the serious risk posed by having close relatives with the disease.
Men are 2.5 times more likely to develop prostate cancer if the disease has affected their father or brother.
Prostate Cancer UK, which carried out the research, also found that only one in 10 GPs are likely to ask their male patients if any of their relatives have had prostate cancer.
The charity's chief executive Angela Culhane said: "There's no denying that GPs in the UK today face tremendous pressure to start conversations with patients regarding an ever-growing list of medical conditions.
"We need men to feel empowered to take control of their own health, find out their family history and pro-actively ask their GP whether they need tests for the disease due to their risk of developing it. Currently this isn't happening nearly enough and the increased risk due to family history of prostate cancer is being dangerously overlooked by both men and their GPs.
"Too many men are walking around completely blind to the serious danger they could face. This must change."
Each year more than 40,000 men in the UK are diagnosed with prostate cancer and around 11,000 die from the disease.
The new study was based on an analysis of Public Health England cancer data and an online survey of 1,901 adult British men.
The findings were released in the run-up to Father's Day, next Sunday.
Ms Culhane added: "Every single one of us can do our bit to reduce the number of men who lose their lives to prostate cancer every year in the UK.
"This Sunday, Father's Day, ask your dads, brothers, grand-dads, husbands, partners and friends about prostate cancer and urge them to book an appointment with their doctor if they have a family history of the disease."
Prostate cancer can be successfully treated if caught in time, but the disease often displays no symptoms in the early stages.
As well as a family history of the disease, two other important risk factors are being aged over 50 and black ethnicity.
http://www.aol.co.uk/living/2017/06/12/family-connection-warning-over-prostate-cancer-risk/