Pages

Showing posts with label Cancer - Cervical. Show all posts
Showing posts with label Cancer - Cervical. Show all posts

Thursday, 27 February 2020

E. coli gut infection linked to bowel cancer

A common type of gut bacterium may increase a person's chance of developing bowel cancer, according to a study published in the journal Nature.

Cancer in the colonImage copyrightGETTY IMAGES
A common type of gut bacterium may increase a person's chance of developing bowel cancer, according to a study published in the journal Nature.
The bacterium is a type of E. coli infection, present in up to one in five people, scientists believe.
It releases a toxin which experts say can damage the cells that line the bowel, potentially turning some cells cancerous over time.
There are around 42,000 new cases of bowel cancer each year in the UK.
Experts do not yet know how many of these might be linked to the E. coli strain that makes the toxin colibactin.

How dangerous might it be?

The researchers suspect it may contribute to a minority of bowel cancer cases - one in 20 or five in every 100 - but more research is needed to confirm the link.
There is no routine test for the bacterium currently, and it is not clear yet that people who have it will be at heightened risk.
In some people it may live in the bowel and cause no issue.
It is not the first infection to be linked with cancer, however. HPV is a virus that causes cervical cancer and H pylori infection is associated with stomach cancer.

Is it the same as food poisoning?

No. This particular E. coli strain is not one of the ones linked to food poisoning outbreaks.
There are lots of different types of E. coli. Many are part of the normal gut flora - the trillions of bacteria that naturally live in the bowel.

What did the study find?

The team, from The Netherlands, the UK and the US, used miniature replicas of the human gut, grown in the lab, to test the effects of the toxin on cells.
They then compared the damage seen with more than 5,000 bowel cancer samples taken from patients and found identical patterns or "fingerprints" of DNA damage in around 5% of the samples.
A line

What are bowel cancer symptoms?

  • a persistent change in bowel habit - going more often, with looser stools and sometimes tummy pain
  • blood in the stools without other symptoms, such as piles
  • abdominal pain, discomfort or bloating always brought on by eating - sometimes resulting in a reduction in the amount of food eaten and weight loss
Most people with these symptoms do not have bowel cancer, but the NHS advice is to see your GP if you have one or more of the symptoms and they have persisted for more than four weeks.
Source: NHS UK
A line

How do the findings help us?

Experts say it may be possible to develop a more sensitive test to detect early bowel tumours using this knowledge about the toxin.
The findings may also offer a way to prevent some bowel cancers, by getting rid of the bacterium from the body before it can do any harm, using existing antibiotics.
One of the researchers, Prof Hans Clevers, from the Hubrecht Institute in The Netherlands, said: "Common antibiotics will kill these bacteria.
"This is the first time we've seen such a distinctive pattern of DNA damage in bowel cancer, which has been caused by a bacterium that lives in our gut."
He said there may be other gut bacteria that do the same.
Probiotic treatments that contain a similar strain of E. coli, called Nissle 1917, might also pose a risk potentially, he added - but these are not the same ones found in yoghurt drinks sold in supermarkets.
"Although it might sound scary, there's still lots left to understand about our how our gut bacteria affect our health, what we could do about it, and how much impact it has on bowel cancer risk," says Nicola Smith, senior health information Manager at Cancer Research UK, who funded the work.
"In the future, knowing what role bacteria in our gut plays could change the way we detect and prevent bowel cancer.
"But we do know that around half of bowel cancer cases can be prevented by not smoking, keeping a healthy weight and eating a balanced diet - so there's plenty of changes that you can make right now that will reduce your risk," she added.
Genevieve Edwards, chief executive at Bowel Cancer UK, said: "Although this research is at an early stage, it adds to the growing body of evidence about the role that bacteria and other microorganisms that live in our gut may play in bowel cancer development. "

https://www.bbc.com/news/health-51626946

Tuesday, 24 September 2019

Papaya leaves help fight cancer, find scientists - MUST READ

Papaya has been declared a new super fruit after scientists found that it can prevent and may be able to treat a wide range of cancers.



Image result for papaya leaf

Researchers found that papaya was an effective anti-cancer agent against cervix, breast, liver, lung and pancreas cancers.
They tested their theories by using a tea made from the extracts of dried papaya leaves and put them in dishes which contain cancerous cells.
The team of researchers found that the papaya leaf extract boosted the production chemicals that regulate the immune system.
Scientists from the University of Florida, who were behind the study, say that papaya may be used as an alternative cancer treatment.
Dr Nam Dang, of the University of Florida, said the findings published in the Journal of Ethnopharmacology were groundbreaking.

"Papaya has a dramatic anticancer effect against a broad range of lab-grown tumours, including cancers of the cervix, breast, liver, lung and pancreas," he said.
"Papaya leaf extract boosts the production of key signalling molecules called Th1-type cytokines.
"This regulation of the immune system, in addition to papaya's direct anti tumour effect on various cancers, suggests possible therapeutic strategies that use the immune system to fight cancers."
Dr Dang said researchers found no side effects to taking papaya leaf as a treatment in their tests.
"The papaya extract did not have any toxic effects on normal cells, avoiding a common and devastating consequence of many cancer therapy regimens," he said.
"The success of the papaya extract in acting on cancer without toxicity is consistent with reports from indigenous populations in Australia and Vietnam.
"Based on what I have seen and heard in a clinical setting, nobody who takes this extract experiences demonstrable toxicity; it seems like you could take it for a long time as long as it is effective."
Dr Dang said the results suggested that the papaya extract induced cell death.
https://www.telegraph.co.uk/foodanddrink/foodanddrinknews/7414067/Papaya-helps-fight-cancer-find-scientists.html

- - - - - - - - - - - - - -

See also:  

Promising treatment kills cancer stem cells - American paw paw (NOT papaya)

Sunday, 22 September 2019

Even in The Face of Impossible Odds – Proof You Can Beat Cancer

Jane McLelland was supposed to die in 12 weeks. At least that’s what the statistics say when cervical cancer has spread to a woman’s lungs.
By Lee Euler / March 3, 2019
But this 35-year-old UK physiotherapist, wasn’t ready to give up on life when she got the bad news in 1999. She had too much to live for. She refused to accept her prognosis. Instead, she threw herself into research and came up with a plan.
It worked. Here’s what she did. . . and what might help you, too. . .
Jane decided she would starve the tumor with anti-cancer nutrients and herbs, and cut off its supply lines until it shrank and died. At the same time, she would keep her healthy cells and organs well nourished.
It was a daunting task, but all seemed to be going well until she was hit by a new, massive blow. In 2003 she was diagnosed with therapy-related leukemia, a little known late-stage side effect of the chemotherapy that she had unwisely decided to undergo years before when she was first diagnosed. This “side effect” is almost always fatal.
Her situation seemed hopeless. But in 2004 the results of the protocol she started five years earlier were in. The cancer was gone. Jane remains cancer free to this day.
Poor experience with physicians
Jane’s problems actually began way back in 1989 when some mildly abnormal cells were found. After treatment she was told repeatedly during the following five years that there were no more abnormalities.
But she was diagnosed with cancer in 1994 just the same. Her gynecologist turned out to be totally incompetent, a fact that became obvious a few years later when there was a national recall of over a thousand of his patients.
She also had a bad time with her surgeon. She hadn’t borne children but she still had hopes of raising a family in the future. Yet her request to freeze some of her eggs before chemotherapy and radiation was brushed aside.
Her experience with her oncologist was no better. She found him to be “brusque, dismissive and scornful” of other options she suggested. In general, she found the oncologists she met to be arrogant and dogmatic, unwilling to consider anything but their “gold standard” treatments — and certain they know what’s best for you.
Five years after she first learned she had cancer, and after all these negative experiences with conventional cancer treatment, she was told her disease had progressed to stage 4 – the “death sentence” I described at the beginning of this article. That’s when she realized she would have to become her own expert if she was to have any chance of survival.
Taking the first steps to regain health
She started by making changes to her diet, even though the medics said this was useless.
She learned that cancer feeds on glucose, so it made sense to her to opt for a healthy low carbohydrate diet where foods that would spike blood sugar and insulin-like growth factors were eliminated. She also kept saturated fats to a minimum, avoided foods that could trigger inflammation, and reduced her overall calorie intake.
Then she changed her oncologist. This was essential. Jane found someone who would be a collaborator, not a dictator.
Because certain enzymes and other factors are linked to inflammation and fuel cancer growth, it made sense to take something that would inhibit them, like low-dose aspirin. She put this to her thoracic surgeon (who operated to remove a third of her lung), but he thought not. There wasn’t enough evidence to support its use, and it could be risky, he suggested.
She ignored his advice and took it anyway as well as other anti-inflammatories — ginger, curcumin and omega 3 fish oils.
Jane also made regular visits to an integrative doctor who specialized in cancer.
Stepping up natural treatments
He prescribed folate, because methotrexate, the chemotherapy drug she’d taken when first diagnosed, would have depleted it. Folate is an important building block of DNA.
He also recommended B vitamins to detoxify excess “bad” estrogen (estradiol), which stimulates tumor growth, and niacin to starve cancer by reducing fat.
She also drank green tea, green juices, and a juice made from apple, carrot, celery and beetroot.
Her choice of anti-cancer supplements included mahonia aquifolium extract, EGCG from green tea, gymnema sylvestre, hydroxycitrate, pycnogenol, silibinin (milk thistle), ellagic acid (from strawberries), resveratrol (from red grapes), glucosamine sulphate, nattokinase, and CLA (conjugated linoleic acid).
The supplement program aimed to accomplish several things.
First, it targeted and blocked different tumor pathways and growth factors. Second, it reduced the likelihood of cancer cells getting stuck in blood vessel walls where they could establish themselves and grow new tumors. Third, it would make chemotherapy more effective.
To boost the immune system, she took other supplements. Medicinal mushrooms, including maitake-D fraction extract, beta-glucans, MGN3 (a rice bran extract), DHEA and melatonin. She was also advised to eat all the day’s food within a narrow time frame so as to mimic fasting and help raise immunity.
Reluctantly agrees to chemotherapy
All Jane’s instincts told her high-dose chemotherapy was entirely wrong, yet despite grave misgivings she agreed to it.
Even though her oncologist accepted it was a crude and blunt tool that caused a lot of collateral damage, she had nothing else to offer this patient.
But after several months, Jane was not prepared to put up with its debilitating effects any longer and managed to persuade her oncologist to lower the dose over the next four months.
Nine months later, well past the date when she was “supposed” to be dead, she was alive and sported blood markers that indicated no detectable cancer in her body. But she knew it was very likely the cancer would come back, so she maintained the protocol and added to it.
Time for IVC and UBI
Jane now visited a different integrative doctor in order to receive intravenous vitamin C (IVC) and Ultraviolet Blood Irradiation (UBI).
The latter involves taking a syringe full of the patient’s blood, exposing it to ultraviolet C light, then reintroducing it into the body. This technique stimulates a powerful immune response, kills pathogens and improves the abnormal micro-environment around cancer cells.
At the same time, Jane added shark liver oil to her regimen as well as genistein, quercetin, chromium picolinate and vitamin K3. She also focused on establishing a good balance of bacteria in the gut as this is so important for a healthy immune response.
She had some bad news when test results from her first integrative doctor found a large number of parasites called Blastocystis hominis in the gut. Treatment involved intensive therapy over several months with a lot more supplements and dietary changes.
Chemotherapy-induced leukemia
All seemed well for the next four years, but in 2003 she was suffering with fatigue and night sweats. Tests run by a third integrative doctor she consulted suggested she now had acute myeloid leukemia (AML).
This was almost certainly a direct result of chemotherapy and radiation treatments which damage the bone marrow. Therapy-related blood cancers have an extremely poor prognosis.
The treatment prescribed for AML was yet more chemotherapy, which she considered madness, so she decided to step up her arsenal of helpers instead.
Diet, supplements and other natural therapies kept her cervical cancer at bay, but for AML, additional big hitters were required.
It was time to investigate drugs. . .but not the ones oncologists hand out.
Beneficial pharmaceuticals
Many approved drugs used for a variety of purposes also have anti-cancer activity. They are not approved for cancer, but any doctor can prescribe “off-label” drugs if they are so minded.
The first promising pharmaceutical she came across was the blood clot inhibitor, dipyridamole. According to the medical literature, this has powerful immune-protective and anti-cancer properties.
The next was lovastatin. As well as lowering cholesterol, it was found to cause pronounced apoptosis in her type of leukemia. She discovered that a combination of lovastatin with the anti-inflammatory drug etodolac multiplied the anti-cancer effect five-fold.
Each drug was low in toxicity and starved the cancer of major metabolic drivers in different ways.
Months later her blood markers were back in the normal range and she has been cancer free for almost 15 years.
A combination of approaches is needed
Jane’s recovery is truly remarkable considering she was diagnosed with cancer in the last century. She had to act as her own guinea pig to come up with a constellation of therapies to target cancer from all angles.
Jane has continued to research better approaches to treating cancer and now advises other cancer patients.
She believes today’s entire focus on genes in conventional research is wrong. It certainly has a place, but it should be combined with treating the altered metabolism that’s common to all cancers.
She writes, “In the mad dash to get rid of a tumor, the patient is over-treated with high levels of either chemotherapy, radiotherapy or targeted therapies. This approach is doomed to fail — it only makes the patient more resistant to future treatment.
“Focusing on the DNA does not affect the cancer ‘stem cell’. Cancer returns harder and more aggressively than before. The cancer mutates and eventually becomes resistant to these ‘targeted’ treatments.
“Treating the cancer metabolism on the other hand, alongside targeted approaches, will reach the stem cell and offer the real opportunity for a cure.”
Our last issue discussed an herbal extract that has so many applications, you could call it a wonder drug (if it was a drug…) If you missed this valuable news, it’s running again below.

References:

  1. How To Starve Cancer by Jane McLelland, Agenor Publishing, 2018
https://www.cancerdefeated.com/even-in-the-face-of-impossible-odds-proof-you-can-beat-cancer/

Friday, 9 February 2018

Year of Champions: Taking down cervical cancer

Prof Dr Woo Yin Ling is determined to reduce, if not eradicate, incidences of cervical cancer among Malaysian women.
Year of Champions: Taking down cervical cancer
As a gynaecological oncologist, Dr Woo Yin Ling is both a clinician as well as a researcher. What gives her greatest satisfaction is tending to patients and helping them deal with their cancer diagnosis under the best possible care. Photo: The Star/Azman Ghani
The Universiti Malaya Medical Centre (UMMC) gynaecological oncologist has made it her mission to combat the disease which is currently the third most common cancer and the third leading cause of death among women in Malaysia.
“That is the prime of their lives. Malaysia has one of the best Human Papilloma Virus (HPV) vaccination programmes in the region, which we implemented back in 2010. But while we have started to get rid of the infection and disease, we also need to have a more sensitive method of detection.
“The reason why cervical cancer is so prevalent is because women don’t screen. And women don’t screen because the pap smear – the traditional screening method practiced here – is intrusive, uncomfortable and embarrassing. Even for me, going for a pap smear is unpleasant. I put it off because … well, it is embarrassing.
“But we are on the brink of introducing a new screening process where women can do the test themselves in the privacy of their homes. This will change things … we will see a shift in the numbers,” says Dr Woo, 45.
With a self-testing kit, she asserts, screening will be as easy as taking a swab on our own and sending it to the lab for testing. The kits come with instructions which are easy to follow.
“It is smaller than a tampon and it is certainly less invasive,” she says.
She adds that results from HPV DNA testing – the recommended method of testing by the World Health Organisation – are more accurate than pap smears.
Dr Woo deals with female cancers. She’s a clinician as well as a researcher which means that she tends to patients in advanced stages of cancer as well as conducts research that can potentially advance cancer treatments and slow the onset of the disease.
Dr Woo, however, is most passionate about interacting and consulting with patients.
“If you asked me to give up one, I’d give up research. I went into medicine because I like the clinical aspects of my job. Even my research at this point is all patient-centered.
“As a student, I had a supervisor who was very good at what she did but also very compassionate. That was when I first saw how doctors can touch lives. She looked at the human first and then the disease and that inspired me. I realised then that’s what I wanted to do.
“I feel it is a privilege to be able to help women who are dealing with cancer. There is nothing more real than dealing with the pain of life and death, and I value the responsibility of helping my patients go through it. They are mothers, sisters, daughters … people who are very important in our lives,” she shares.
Dr Woo did her medical degree at Trinity College in Dublin, Ireland and her post graduate research and training in Britain. She returned to Malaysian in 2010 after spending 20 years studying overseas. Working closely with the Health Ministry, Dr Woo is bent on making a positive difference in cancer treatment and prevention for Malaysian women.
“The ministry is very proactive and though there are constraints, it is about working within the constraints to move forward.
For cervical cancer screening, for example, they do realise that HPV DNA screening is the way forward. Together, we are also looking at how we can use technology to enable us to access our results via our mobile phone.
“But change can’t happen overnight. We need to know how we can adapt these new methods to the Malaysian setting. We need to know the concerns of Malaysian women and educate and empower them first.
“We must create awareness about the disease and the need for screening. We also have to change the mindset that the traditional pap smear is the only and most effective method of screening,” she says.
Apart from her work on cervical cancer, Dr Woo is also elbow deep in research on ovarian cancer.
“My work has been rewardingly challenging. Every day is different but my clinical work is especially very meaningful and rewarding. You can really build a relationship with most patients and that is rewarding. Sometimes we can only spend a few minutes with each patient but even so, they are appreciative of those few minutes, which makes it my responsibility to give them my best,” she says.
https://www.star2.com/topics/yearender-2017/2017/12/30/year-of-champions-taking-down-cervical-cancer/