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Showing posts with label L-Carnitine. Show all posts
Showing posts with label L-Carnitine. Show all posts

Saturday, 26 March 2022

Extra Protein, Extra Performance? - Excess protein turns into fat

By taking large quantities of protein, athletes hope to be able to run that extra mile or lift that extra weight without failing their drug tests. But, does it work? More importantly, is it worth the risks?



Joe Schwarcz PhD | 20 Mar 2017 


No one can deny the importance of proteins in our diet. They are vital for countless body functions, especially tissue growth and repair. Proteins also provide energy to the body and help ensure a strong immune system. In striving to excel at their respective sports, many athletes subscribe to the notion that protein supplements enhance their physical performance. The existence of a multi-billion dollar supplement industry, however, does not prove that such products are necessary. Only a rigorous scientific investigation can do that.

Before delving into the science of protein supplements, let’s take a look at the differences between a supplement and a drug. Legally, dietary supplements cannot claim to cure, treat or prevent a disease, although they can convey how they potentially affect the body. Supplements do not have to go through the same regulatory process as drugs which undergo a thorough assessment for safety and efficacy before going on the market. Protein supplements therefore do not have to be proven effective before being sold. Indeed, their effectiveness continues to be a matter of ongoing debate, and with a lack of concrete evidence, many people continue to invest in this growing market.

An understanding of protein’s role in the body allows us to make an attempt at assessing the role of supplements. A normal adult requires only forty to fifty grams of protein per day in order to supply essential amino acids and replace the nitrogen eliminated in urea as waste. Essential amino acids are the nine out of twenty amino acids that the body requires but cannot produce on its own. When an amino acid is broken down, the nitrogen it contains is converted into urea by the liver which then is excreted via the kidneys. 

Many athletes, body builders, or teenage boys who are looking to “bulk up” turn to protein supplements or high protein diets to enhance their performance or accelerate muscle growth. Supposedly, the amino acids arginine and ornithine promote release of growth hormone, a natural hormone that stimulates muscle development. Glutamine and carnitine have also been marketed as strength-enhancing amino acids. By taking large quantities of these proteins, athletes hope to be able to run that extra mile or lift that extra weight without failing their drug tests. But, does it work? More importantly, is it worth the risks? 

A typical American diet contains approximately seventy to ninety grams of protein per day, meaning that most individuals far surpass their daily protein requirements. Dietary protein is used to replace proteins which were previously broken down and used by the body. Extra protein does not get stored. Instead, excess amino acids get converted to carbohydrate or fat. Thus, it seems that additional protein intake will not directly increase muscle growth, strength or physical performance and could even lead to weight gain and fat deposition, which are surely negative consequences for any athlete.

As a matter of fact, many health experts question the efficiency and safety of ingesting large amounts of proteins. In one study of elite junior weightlifters, consumption of protein supplements including glutamine and carnitine before workout did not result in changes in blood hormone levels during heavy training. Another study with bodybuilders found no change in blood growth hormones after consuming various mixtures of amino acids. Not only that, excess protein intake can have deleterious effects on the body. The recommended dose of protein intake for a normal adult is 0.8 g per kg of body weight per day. That’s 54 g for a person weighing 150 lb. High level athletes (and we are talking about those who compete at the national and international level, not your fifteen year-old who wants to impress a girl) require a bit more than that to compensate for their high energy output. According to one study, athletes competing in power or strength sports need about 1.6 g of protein per kg of body weight, while endurance-trained athletes need about 1.3 g per kg. There is still debate about the exact amount of proteins athletes should consume, but the consensus is that anything over 2.0 g per kg of body weight per day is excessive and no scientific evidence supports beneficial effects above this level. High protein diets on the other hand advocate protein intake on the order of 200 to 400 g a day! Too much protein intake can lead to liver and kidney overload; the liver cannot convert nitrogen into urea fast enough and the kidney has to deal with extra urea. Too much urea results in higher demand for water, which leads to dehydration. And we all know how important it is for athletes to stay hydrated. More serious problems include hyperaminoacidemia (excess amino acid in blood), hyperammonemia (excess ammonia), hyperinsulinemia (excess insulin), calcium loss and overreaction within the immune system.

All you need, really, is a balanced diet and healthy lifestyle. No need to wreak havoc in your body with excessive supplementation. A 3-oz. portion of roast white chicken meat already contains 26g of protein. Beans average about 15g per cup, and pasta contains 5g per cup. While there is evidence that extra protein can be beneficial for athletes, you really don’t need much. A double-blind study with judoists showed that a daily protein supplement of 0.5 g per kg of body weight improved the maximum oxygen uptake. The effects disappeared when judoists stopped taking the supplements. However, such amounts can be obtained from a healthy diet. The body cannot tell the difference between proteins coming from foods and proteins coming from bottles. Proponents of supplements claim that they are more readily absorbed than the protein from food and that certain amino acids increase muscle mass and decrease body fat. The fact is, there is no reason to believe that faster absorption is better; after all, muscles don’t just grow from one second to the next. The best way to gain muscle mass is to add body weight by increasing calorie intake from low fat carbohydrate sources.

Endurance or strength exercise does increase the body’s dietary protein requirement, therefore athletes who are generally more physically active than the average person, require more dietary protein. Just how much more is hard to determine but needs can certainly be met without resorting to protein supplements. Furthermore excessive protein intake is not without problems. Potential side effects include dehydration, which is secondary to high urea excretion, gout, liver and kidney damage, calcium loss, bloating and diarrhea. Yes, athletes do need more protein, but not in gargantuan amounts. And supplements are great, for those who sell them. There is nothing you cannot obtain from a healthy diet. As for bulking up... exercise by itself already significantly increases growth hormone levels, so leave the health food stores alone and head for the gym!

https://www.mcgill.ca/oss/article/health-you-asked/extra-protein-extra-performance

Wednesday, 17 April 2013

Eating red meat damages your heart, U.S. scientists verify

meat

Tuesday, April 16, 2013 by: PF Louis

(NaturalNews) A recent highly publicized by mainstream media study supposedly confirms the suspicions of red meat and heart health. But it's not saturated fats they point to as the villain, it's a compound in red meat known as carnitine.

Studies with mice showed that gut bacteria breaks down carnitine. As the carnitine gets broken down by gut bacteria, the waste from this process creates a gas that ultimately creates trimethylamine N-oxide (TMAO) in the liver. [1]

TMAO can create arterial inflammation, they say. But of course, the doctors involved with this study frame this within the accepted cholesterol concerns. It's the formerly ignored carnitine that's the bad guy now because it creates cholesterol.

The report also put out a frightful message for vegetarians who use L-carnitine supplements. They proclaimed that they were more at risk because the L-carnitine supplements could foster the type of bacteria that would kindle the creation TMAO.

Amazingly, they suggest red meat eaters use antibiotics to eliminate those gut inhabiting bacteria that begin the TMOA creation cycle. Later in this article you'll discover a dissenting MD on these claims.

Unfortunately, this and other similar studies tend to make no distinction between factory farm commercial meat and meat from organically raised livestock. Of course, processed meats with nitrates are even worse and with increased risk factors for cancer and other diseases. [2-3]

For those who refuse to go vegetarian, it's wise to avoid processed meats and factory farm CAFO (confined animal feeding operation) beef or poultry. Those animals are forced into terribly crowded, filthy, and unhealthy confines.

They're inoculated heavily with antibiotics to stem diseases from those conditions and make them fatter. They're fed GMO grain mash foods, instead of grass, with toxic glyphosate (Roundup) pesticides residue traces. All these don't just disappear. They are ultimately consumed by you.

Paleo people should recognize that primitive man did not eat meats from CAFOs.

Try to get grass fed organic beef, pork, or poultry from sources that let the animals roam and graze a bit without getting injected with hormones and antibiotics.

Doctors who disagree with the cholesterol issue and this study


More than one MD has stepped out of the box, even Dr. Oz, to discredit the cholesterol scare that forces many to use statins. Former heart surgeon Dr Dwight Lundell is another. [4]

Statins do reduce cholesterol, and that's the problem. We need cholesterol for cell walls, brain cells, and the myelin sheath that protects our nerves. It also provides the first phase of converting sunlight to vitamin D3 (http://www.naturalnews.com/035033_cholesterol_disinformation_fats.html).

The side effects of statins are from its intended effects. Lowering cholesterol increases the likelihood of earlier dementia. Meanwhile, they do nothing to stave cardiovascular disease, which is the result of arterial inflammation or calcification.

Much of the arterial inflammation comes from processed trans-fatty acids, HFCS, and excess refined carbohydrate processed food diets. An imbalanced ratio of omega-6 to omega-fatty acids is another contributor, it should be 3 to 1 or less.

Calcium deposits in arterial walls also cause inflammation or calcification. It's important to take in ample magnesium and vitamin K2 to transport calcium out of blood vessels and into bone matter.

Dr. Robert Lustig's controversial lecture "Sugar: The Bitter Truth", which has gone viral on YouTube, details how cholesterol counts are useless unless you can detect a particular subtype of LDL that is often from high sugar and HFCS diets, not saturated fats.

Dr. Stephen Sinatra, who co-authored The Great Cholesterol Myth with Jonny Bowden, PhD, goes into detail on exactly what this subtype of LDL is, and how it creates inflammation by burrowing under the inner arterial wall's outer skin, but not by "clogging arteries". [5]

Dr. Sinatra also isn't keen on the study reported in this article. He does recommend eating less red meat and avoiding factory farm meats which are so contaminated with chemicals and antibiotics that it's impossible to isolate carnitine as the cause of TMAO. [6]

Sources for this article include

[1] http://www.bbc.co.uk/news/health-22042995
[2] http://www.cnn.com/2012/03/12/health/red-meat-shorten-lifespan
[3] http://no-baloney.com/2012/02/06/of-bacon-and-beets-nitrates-in-food/
[4]http://www.naturalnews.com
[5] http://www.drsinatra.com/cholesterol-definition
[6] http://www.drsinatra.com/l-carnitine-is-not-only-safe-its-essential

 

Articles Related to This Article:


Processed Meat Unsafe For Human Consumption; Cancer Experts Warn of Dietary Dangers
Artificial meat would be a preferable alternative to the cruelty and environmental impact of factory farms
The Energetic Contamination of Beef Products (Transcript)
Eating Meat Kills More People Than Previously Thought
Fresh meat versus processed meat: Here's why it matters
Exposed - The dirty little secret of the meat industry

http://www.naturalnews.com/039940_red_meat_carnitine_heart_disease.html

Sunday, 23 December 2012

Migraine - Effects of Magnesium and L-Carnitine

Magnesium and L-Carnitine Reduce Migraine Frequency and Severity

December 2012

Magnesium and L-carnitine impact the frequency and severity of migraines, a new clinical trial published in August 2012 reports. The Centers for Disease Control and Prevention (CDC) state that 21.8 percent of women and 10 percent of men are affected by migraines.

In addition to routine treatment, the researchers assigned the 133 subjects with migraines to receive:

1. Magnesium oxide 500 mg per day,
2. L-carnitine 500 mg per day,
3. 500 mg per day magnesium plus 500 mg per day L-carnitine, or
4. No intervention to serve as the control group.

After 12 weeks of supplementation, the researchers collected data, including migraine attacks per month, migraine days per month and headache severity. The investigators also measured serum concentrations of magnesium and L-carnitine.

The researchers found a significant reduction in all migraine indicators in all studied groups, including a significant reduction in migraine frequency. More specifically, the researchers determined that magnesium supplementation had a significant effect on all migraine indicators.

The investigators concluded that supplementation with magnesium oxide and L-carnitine, as well as supplementation of magnesium plus L-carnitine, in addition to routine treatments, could be effective in treating migraines.

Reference:

Tarighat Esfanjani A, et al. Biol Trace Elem Res. 2012 Aug 17. [Epub ahead of print.]

Source: Magnesium and L-Carnitine Reduce Migraine Frequency and Severity

Wednesday, 19 September 2012

Fight Chronic Fatigue Syndrome ...


How to Wake Up from Chronic Fatigue Syndrome


By Michael A. Smith, MD

Chronic fatigue syndrome (CFS) is a mysterious medical condition that affects approximately 500,000 Americans.1 It typically targets women between the ages of 25 and 45, but it can actually affect anyone at any age. Unfortunately, the disease has no known cause, and there aren’t any tests that can measure for it.

CFS is defined as a set of symptoms that include prolonged, overwhelming fatigue that cfsbegins when you wake up and lasts the entire day. This fatigue is often amplified when exercising, as your muscles become tired very quickly.

Many people afflicted with CFS have complaints that extend well-beyond fatigue. Mood swings, muscle spasms, pain, headaches, sleep disturbances, and loss of appetite are all common complaints that come along for the ride. And some experts now believe it may run in families.2

Many researchers believe that CFS is triggered by a number of factors including infectious agents, mental or physical stress, nutrient deficiencies, immune system abnormalities and maybe even allergies.2,3

How is Chronic Fatigue Syndrome Diagnosed?


A diagnosis of CFS can be made only when a patient has suffered from persistent, unexplained fatigue for at least six months. In addition to the fatigue, four of the following symptoms must also be present for a diagnosis:1

  • Disrupted, non-restful sleep
  • Lack of short-term memory or concentration
  • Sore throat and cough
  • Tender lymph nodes
  • Aching or stiff muscles
  • Multi-joint pain without swelling or redness
  • Headaches of a new type, pattern, or severity
  • Post-exertion fatigue lasting more than 24 hours
  • Persistent feeling of illness for at least 24 hours after exercise
Remember: No one knows for sure what causes CFS or how to diagnose it. So we won’t get bogged down in all of that in this post. Instead, we’ll focus on helping people who are suffering from it to feel better.

Below are our top nutritional suggestions for anyone dealing with CFS. They’ve helped a lot of our members, and they may help you too.

Fighting Fatigue with CoQ10


The first place to start is with coenzyme Q10 (CoQ10). This is a potent antioxidant that aids in metabolic reactions, including your cellular energy formation.

One particular study measured CoQ10 levels in people afflicted with CFS. The authors compared CoQ10 plasma levels in 58 people who had CFS and 22 healthy individuals. What they found was that CoQ10 plasma levels were significantly lower in the CFS group.4
The researchers also reported that there were significant and inverse relationships between CoQ10 and the total score on the test used to measure fatigue. Patients with very low CoQ10 suffered significantly more from concentration and memory disturbances.4
The average CoQ10 dose for healthy individuals is between 100 and 200 mg/day. So, if you suffer from CFS, you might want to target your dose at the upper end of this average range.

DHEA is a Powerful Fatigue Buster


DHEA is a hormone. It plays a role in boosting immune function, maintaining healthy metabolism, and promoting testosterone balance. It’s also been singled out for its ability to help CFS patients. As it turns out, people afflicted with CFS typically have low blood levels of DHEA.5,6
In a study of 15 subjects with CFS, 15 subjects with major depression, and 11 healthy subjects, DHEA levels were significantly lower in the CFS subjects compared to the healthy group. As a result, the authors concluded that DHEA has a potential role both therapeutically and as a diagnostic tool in CFS.6
Another study of DHEA levels in 22 CFS patients found normal DHEA levels but a blunted serum DHEA response to adrenocorticotropic hormone (ACTH) injection. This means that people dealing with CFS are unable to produce DHEA when they need it. The authors concluded that this blunted response represents an endocrine abnormality in CFS.7
However, before taking DHEA yourself, we suggest a blood test. From there, our Health Advisors will be happy to suggest an appropriate daily dose for you.

Additional Energy Boosters to Help Manage CFS


A number of nutrients have been studied for their ability to boost cellular energy in people with CFS. Let’s take a look at three important ones.

1. NADH

NADH is essential for optimal cellular energy production. A well-designed, placebo-controlled clinical study examined the use of NADH in 26 CFS patients. They received either 10 mg of NADH or placebo for a four-week period. The results showed that 31% of those who took NADH felt more energy, compared to only 8% for the placebo group.8
2. L-Carnitine

Researchers have found that people who have CFS are often deficient in the energy-boosting amino acid L-carnitine. 9 Studies show that carnitine given as a supplement to CFS patients results in better functional capacity and lessening of disease symptoms.10 Life Extension suggests a daily dose of 1,000–2,000 mg of L-carnitine.

3. Magnesium

Magnesium plays an important role in energy metabolism as well. The body vigilantly protects blood magnesium levels, in part because 350 enzymatic processes depend on magnesium for activation. A placebo-controlled clinical study was conducted on CFS patients who were found to have low magnesium levels.

Thirty-two patients received either a placebo or intramuscular magnesium injections every week for six weeks. Patients treated with magnesium reported improved energy levels, better emotional state, and less pain.11

Traditional Medicine Offers No Hope for Chronic Fatigue


A diagnosis of CFS often leaves people feeling alone and pretty helpless. Since traditional medicine doesn’t have any treatment options to offer, conventional doctors usually prescribe antidepressants as a Band-Aid. We think this should be a last resort though.

A targeted nutritional approach is really a much better place to start. Supplementing with the right nutrients can at least improve your energy levels and offer you a path toward returning to a normal life. So please consider this route when weighing your options.



Have you or a loved one been diagnosed with chronic fatigue syndrome? What has helped? Please share your story in the comments.

References

  1. http://www.cdc.gov/cfs/general/index.html
  2. Am J Psychiatry. 2003 Feb;160(2):221-36.
  3. J Allergy Clin Immunol. 1998 Aug;102(2):222-30.
  4. Neuro Endocrinol Lett. 2009;30(4):470-6.
  5. Van Rensburg SJ et al 2001
  6. J Affect Disord. 1999 Jul;54(1-2):129-37.
  7. Horm Metab Res. 1999 Jan;31(1):18-21.
  8. Ann Allergy Asthma Immunol. 1999 Feb;82(2):185-91.
  9. Neuropsychobiology. 1995;32(3):132-8.
  10. Neuropsychobiology. 1997;35(1):16-23.
  11. Lancet. 1991 Mar 30;337(8744):757-60.
http://blog.lef.org/2011/10/how-to-wake-up-from-chronic-fatigue.html