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Showing posts with label Roche. Show all posts
Showing posts with label Roche. Show all posts

Sunday, 19 September 2021

COVID-19: Life-saving antibody treatment to be rolled out across UK from next week

Ronapreve, an antibody cocktail developed by Roche and Regeneron, will be initially used to treat COVID-19 hospital patients who have not developed an adequate antibody response.

The government said it has secured enough supply of the new therapeutic treatment for NHS patients across the four nations. File pic

A new antibody treatment for COVID-19 will be rolled out to NHS patients across the UK from next week, the government has announced.

Ronapreve, an antibody cocktail developed by Roche and Regeneron, will be initially used to treat COVID-19 hospital patients who have not developed an adequate antibody response.

It will be provided to those without antibodies who are aged 50 and over, or those aged 12 to 49 who are immunocompromised, including people with some types of cancer or autoimmune diseases.

Former US president Donald Trump was treated with Ronapreve when he was ill with COVID-19

The drug, which was taken by then-US president Donald Trump when he had COVID-19, has been shown to reduce hospital stays by four days and the risk of death by a fifth.

The government said it has secured enough supply of the new therapeutic treatment for NHS patients across the four nations, with plans to begin treating eligible hospital patients from next week.


Antibody testing will be used to determine whether patients are seronegative, meaning they do not have an adequate existing antibody response and could therefore benefit from the medicine.

Ronapreve was the first antibody treatment to be approved by the Medicines and Healthcare products Regulatory Agency (MHRA) for the prevention and treatment of COVID-19 infections in the UK.

Health Secretary Sajid Javid said: "We have secured a brand new treatment for our most vulnerable patients in hospitals across the UK and I am thrilled it will be saving lives from as early as next week.

"The UK is leading the world in identifying and rolling out life-saving medicines, particularly for COVID-19, and we will continue our vital work to find the best treatments available to save lives and protect the NHS."

UK COVID-19 antibody testing programme: How will it work?

UK COVID-19 antibody testing programme: How will it work?

The drug, a combination of two monoclonal antibodies called casirivimab and imdevimab, will be administered through a drip and works by binding to the virus' spike protein, preventing it from being able to infect the body's cells.

Monoclonal antibodies are man-made antibodies that act like natural antibodies in the immune system.

The Department of Health said clinicians will soon receive guidance so they can start prescribing the treatment.

The MHRA said in August that the clinical trial data it assessed showed that Ronapreve can be used to prevent COVID-19, treat serious infections, and lower the chances of hospital admission.

The trials were conducted before widespread COVID-19 vaccination and before the emergence of variants.

Most people develop COVID-19 antibodies from vaccination or exposure to the virus.

 https://news.sky.com/story/covid-19-life-saving-antibody-treatment-to-be-rolled-out-across-uk-from-next-week-12410623


ALSO:

https://healthticket.blogspot.com/2021/09/covid-19-life-saving-antibody-treatment.html

https://healthticket.blogspot.com/2021/08/immune-boosting-drugs-to-protect-one-in.html

https://healthticket.blogspot.com/2021/09/ronapreve-most-vulnerable-to-get-new.html

Friday, 25 September 2020

Airlines look to Covid tests that give results in minutes

 European airlines are pinning hopes on pre-flight COVID-19 tests that deliver results as fast as pregnancy tests to help restore passengers’ confidence in taking to the skies in confined spaces with shared air.

SEPTEMBER 23, 2020

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Germany’s Lufthansa, at the mercy of government bailouts for survival, is in talks with Swiss drugmaker Roche over deploying so-called antigen tests, according to two people familiar with the discussions, as the airline aims to make them available next month.

Italian operator Alitalia, meanwhile, told Reuters that from Wednesday it would add two flights from Milan to Rome, to the two it is already offering from Rome to Milan, exclusively for passengers with negative tests.

The tests are administered by health authorities at the airports and included in ticket prices. If they prove popular and safe, these antigen-tested flights will be expanded to more domestic, and later international, routes, the airline said.

Unlike laboratory-based molecular tests that have been the staple of health authorities in the pandemic, antigen tests do not require machines to process. Much like pregnancy tests, they can produce results in about 15 minutes.

However the tests require an uncomfortable nasal swab and are not as accurate as the molecular, or PCR, tests. They generally produce more “false negatives” which could mean sick people could slip through the cracks and onto planes.

An increasing number are hitting the market, from companies such as Abbott Laboratories, Becton Dickinson & Co and Quidel Corp and Roche, which is rebranding antigen tests from South Korea’s privately held SD Biosensor.

Airlines are pressing governments to embrace alternatives to blanket travel restrictions amid a resurgence of COVID-19 cases in Europe.

Rapid antigen tests that can be administered by non-medical staff are expected to become available in coming weeks for as little as $7 each, the head of industry body the International Air Transport Association said on Tuesday.

NEGATIVE-ONLY FLIGHTS

Despite the drawbacks of such antigen tests, carriers hope they could tip the balance in convincing people to fly.

“It is to give ... confidence, at a specific point in time, that the result is positive or negative,” said Christian Paulus, a Roche research and development manager.

“The PCR remains the gold standard. Therefore if there are any questions open, or if the clinical appearance of the person who had a negative test, if the person has symptoms like a fever, then you would for sure do confirmatory testing.”

Alitalia launched its “COVID Tested Flights” programme from Rome to Milan last week, and will expand it from Wednesday. Only passengers with negative COVID-19 results can board.

“So far no positive passengers have been found,” said an Alitalia spokesman, adding that many chose to take the airline’s antigen tests the night before the flight. Travellers can access airport-testing facilities via a preferred lane with their tickets.

The airline plans to analyse findings around the middle of October, but already expects antigen-tested flights will be expanded to domestic and later international routes. “First, we have to see how this experiment goes,” the spokesman said.

The pre-flight antigen tests follow a scheme in Italy where such tests were used defensively.

SD Biosensor said its tests had been deployed at Italian airports for incoming tourists, to avoid a renewed COVID-19 wave imported from infection hotspots.

‘BETTER THAN QUARANTINE’

Lufthansa Chief Executive Carsten Spohr last week told employees during a townhall meeting that the airline was in talks with Roche. The drugmaker started selling the rapid tests this week, and said SD Biosensor could initially supply it with about 40 million tests per month.

The Lufthansa tests could initially go to cabin crews, a spokeswoman said, though Bjoern Becker, a senior director of product management, ground & digital services for the Lufthansa Group, said the tests could also be made available to first-class and business-class passengers.

“We think the tests would be a better option than putting somebody into quarantine,” the airline spokeswoman said.

Beyond airlines, Germany is eyeing broader antigen test use from October, including in nursing homes where older patients have been hardest hit by the deadly virus.

Regulators still worry about test accuracy, which typically detect the virus 80% to 90% of the time, below the 95% rate of lab tests.

Still, some officials don’t want the perfect to be the enemy of the pretty good as they pursue some semblance of economic normality.

“They’re good enough,” German health minister Jens Spahn said, pledging antigen tests in “significant quantities”. The state of Bavaria has already ordered 10 million.

Reporting by John Miller in Zurich, Andreas Rinke in Berlin, Ludwig Burger, Patricia Weiss and Ilona Wissenbach in Frankfurt and Emilio Parodi in Milan; Editing by Pravin Char

https://www.reuters.com/article/uk-health-coronavirus-airlines-testing-f/positive-about-flying-airlines-look-to-covid-tests-that-give-results-in-minutes-idUKKCN26E0TD


ALSO:


Airlines call for COVID-19 tests before all international flights


Tuesday, 22 Sep 2020 9:47 PM MYT

PARIS (Reuters) - Global airlines on Tuesday called for pre-departure COVID-19 testing for all international passengers to replace the quarantines they blame for exacerbating the travel slump.

Rapid and affordable antigen tests that can be administered by non-medical staff are expected to become available in "coming weeks" and should be rolled out under globally agreed standards, the head of the International Air Transport Association (IATA) said during an online media briefing.

"We don’t see any alternative solution that would be less challenging or more effective," IATA Director General Alexandre de Juniac said.

Airlines hammered by the pandemic are pressing governments to embrace alternatives to blanket travel restrictions that are still hampering a traffic recovery - and now tightening again in Europe amid resurgent case numbers.

With rapid antigen tests becoming available for as little as $7 each, De Juniac said, airlines will push for their use to be endorsed by International Civil Aviation Organisation (ICAO), the U.N. agency that oversees global aviation rules.

A global agreement is needed to ensure test results on departure are accepted on arrival, he added. "It will also boost passenger confidence that everybody on the aircraft has been tested."

Antigen tests are faster but generally more likely to miss positive cases of the virus than laboratory-based molecular diagnostic tests.

Among companies marketing the new tests, German diagnostics specialist Qiagen said earlier this month it planned to launch a COVID-19 antigen test that provided results in 15 minutes and could be deployed in airports or stadiums.

(Reporting by Laurence Frost; editing by Jason Neely and Mark Potter)

https://www.thestar.com.my/news/world/2020/09/22/airlines-call-for-covid-19-tests-before-all-international-flights

Saturday, 16 May 2020

Roche and Quotient - Antibody testing in the UK


Swiss company Roche Diagnostics claims that it has created a test with 100% accuracy and could provide hundreds of thousands to the NHS every week. 

4 May 2020


Coronavirus antibody test (file pic)
Current testing only identifies those who have it now

Roche claims its lab-based ‘Elecsys’ test can spot 100% of people who have had the virus with no ‘false negatives’ at all. 


Roche Diagnostics said it is already ‘in dialogue’ with the NHS and the UK Government about a ‘phased roll-out of the test from mid-May’. 

A spokesman added: ‘We will be able to provide hundreds of thousands of antibody tests to the UK per week. 


‘Hospitals and reference laboratories can run the test on fully-automated equipment already widely installed by Roche Diagnostics at sites across the UK with results provided in 18 minutes.’

Earlier this month, May 2020, Roche's antibody test won emergency approval from the US Food and Drug Administration.



Another UK research firm claims it has also developed a ‘fast and accurate’ coronavirus antibody test – but it fears the NHS could miss out amid interest in Europe for the tests. 

Researchers for blood-screening company Quotient, based in Edinburgh, have developed a new test for whether people are immune to Covid-19 by spotting whether a person has developed antibodies to the disease. 

The tests involve using serological screening machines – each has capacity for up to 3,000 tests a day and produces results in 35 minutes with 99.8% accuracy, scientists said. 


The company says it has 12 screening machines available, with a further 20 expected to be ready by the end of the year, but it has already had talks with interested parties across Europe.

Quotient is calling for the UK and Scottish governments to begin talks so that the NHS might be able to benefit. 

While the UK Government says it has laboratory capability to test for coronavirus immunity, it is currently being used for survey testing of existing blood samples and the capacity is not known. 

It is also attempting to develop home testing kits, rather than requiring analysis in laboratories, but so far these have proved unreliable. 

On Friday, Quotient received European regulatory approval for the MosaiQ serological screening machines with 100% sensitivity and 99.8% specificity, meaning there is a low chance of a misread or ‘false positive’. 

Chief executive Franz Walt – who was managing director of a laboratory that developed the first diagnostic test for Sars in 2003 – said: ‘We are truly proud to have developed such a fast and accurate test. 

‘This is an outstanding performance by our teams in both Edinburgh and Switzerland. 

We now want to make sure that we can help as many people as possible as quickly as possible. ‘We have strong roots in the UK and want to speak to ministers there so MosaiQ can be used in the amazing national effort to tackle Coronavirus and relaunch the economy. 

‘We realise ministers and the NHS are incredibly busy but are keen to talk given the strong interest from across Europe in the product.’ 

Ed Farrell, chief operating officer at the Edinburgh office, added: ‘We’re incredibly proud of all our work here in Scotland and Switzerland. 


‘100% accurate’ antibody tests ‘could be rolled out within 2 weeks’


Thursday, 14 May 2020

What is the new coronavirus antibody test and can I get one?

A test to find out whether people have been infected with coronavirus in the past has been approved by health officials and could be rolled out within weeks.

  1. ITV REPORT
  2.  

Pharmaceutical giant Roche has developed the test

Pharmaceutical giant Roche has developed the test. Credit: PA


A test to find out whether people have been infected with coronavirus in the past has been approved by health officials and could be rolled out within weeks.
Here are the answers to some of the key questions about the new test:
What is the new test?
Pharmaceutical giant Roche has developed a test which can tell whether somebody has ever had coronavirus.
The test involves taking a small sample of blood and testing it for antibodies which will indicate exposure to Covid-19.
Public Health England (PHE) has evaluated the new Roche test and has approved it as being safe and reliable for widespread use.
The north east has some of the highest rate of cases per 100,000 people in the country.
The north east has some of the highest rate of cases per 100,000 people in the country.
The north east has some of the highest rate of cases per 100,000 people in the country. Credit: PA Graphics

How reliable is it?
The test picks up 100 per cent of people who have had coronavirus.
This means it has 100 per cent sensitivity - making it very reliable,
It also has a specificity of over 99.8 per cent, this means it picks up virtually all people who have not had the virus.
A test that is 100 per cent specific means all healthy individuals are correctly identified as healthy - so there are no false positives
What if I've never had any symptoms of Covid-19?
Whether you've had symptoms or not doesn’t matter.
Experts believe a proportion of people who have had Covid-19 never actually develop symptoms - they are aysmptomatic.
The new test can identify people who have had coronavirus even if they have never had any indication they had contracted it.

Sorry, this content isn't available on your device.

If the test shows I've had Covid-19, am I now immune from it?



Scientists are unsure as there is still a lot to learn about the new coronavirus.
Experts believe that while the presence of antibodies indicates a level of immunity, it is unclear whether people are completely protected and how long immunity - if any - lasts.
There has been some suggestion that immunity could last for two to three years but more work needs to be done.

Swab testing has been carried out at drive through sites around the UK.
Swab testing has been carried out at drive through sites around the UK. Credit: PA

Can I get the new test?
Not yet.
The Government plans roll out the test to front-line workers first, such as those in health and social care.
Number 10 said the new antibody test would "certainly" be available on the NHS, but said commercial discussions with Roche are ongoing.
It is hoped the test will become available to the wider public - although it is unclear whether this will be via the NHS or through commercial websites.
Roche says it will be able to provide hundreds of thousands of antibody tests to the UK every single week.
Coronavirus: Everything you need to know
https://www.itv.com/news/2020-05-14/can-i-get-the-new-covid-19-antibody-test/