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Showing posts with label Deep Vein Thrombosis. Show all posts
Showing posts with label Deep Vein Thrombosis. Show all posts

Tuesday, 17 May 2022

Pancreatic Cancer: Four sensations in the leg could be among ‘first clues’ signalling 'lethal' cancer

 THE ILL-DEFINED nature of cancer symptoms can significantly delay referrals, so keeping well-informed of warning signs is crucial. According to recent findings, however, up to 70 percent of cancer patients are unaware of having an increased risk of blood clots. What's more, deep vein thrombosis (DVT) is sometimes the first clue of pancreatic cancer, which is notoriously difficult to treat.

Cancer is a disease of the cells and organs that is fast-spreading by nature. One surefire way to treat the condition is to catch it during the initial stages of its development. But pancreatic cancer, due to its location deep inside the body, is notoriously difficult to pick up at the outset. Four clues in the legs could be among the first signs of the disease, according to health bodies.

Pancreatic cancer has a unique ability to induce blood into a hyper-coagulative state.

In other words, the blood of patients with pancreatic cancer has an abnormal tendency to coagulate, which confers a higher risk of blood clotting.

Therefore, a clot in the leg is sometimes among the first clues that someone has pancreatic cancer, according to the Cancer Society.

“This is called a deep vein thrombosis," explains the health body.

Blood clots may be among the first signs of pancreatic cancer (Image: Getty )

“Symptoms can include pain, swelling, redness and warmth in the affected leg. Sometimes, a piece of the clot can break off and travel to the lungs, which might make it hard to breathe or cause chest pain."

A blood clot that travels to the lungs is medically known as pulmonary embolism or PE, which carries a high mortality risk.

“Still, having a blood clot does not usually mean that you have cancer. Most blood clots are caused by other things,” adds the Cancer Society.

It recently came to the attention of researchers that up to 70 percent of cancer patients are unaware they’re at a higher risk of DVT than the general population.

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The discovery emerged from the results of a survey carried out by the European Cancer Patient Coalition (ECPC), which assessed patient awareness and knowledge about cancer-associated DVT.

But aside from the fact that the condition is hard to pick up early, pancreatic cancer is also notoriously difficult to treat.

This makes pancreatic cancer the most lethal cancer in the body, according to Doctor Santhi Swaroop Vege, director of the pancreatic diseases group at Mayo Clinic.

In fact, the disease has an overall five-year survival rate of about seven percent, despite the marked medical advances effectuated in recent years.

CAncer

Symptoms of DVT pain include pain, swelling, redness and warmth in the affected leg (Image: Getty )

The disease is typically characterised by non-specific symptoms, such as weight loss, and abdominal pain, making early detection difficult.

The location of the pancreas in the body also makes it difficult to biopsy or image.

Doctor Vege told News Network: “That’s one of the biggest problems we face. Usually, these people will have indigestion, and acid reflux, before finally somebody thinks of a CT scan."

Indeed, the condition tends to be found at advanced stages when abdominal pain or jaundice has resulted.

Cancer: The signs and symptoms

Cancer: The signs and symptoms to look out for (Image: EXPRESS.CO.UK)

“At that time, it’s already late,” noted Dr Vege.
“If [the cancer] is localised to the pancreas and it is not involving the major structures, then the best treatment, of course, is resection - a big surgery.”
The best way to treat pancreatic cancer, however, is to remove the tumour completely before it spreads to neighbouring regions.
Men have a slightly raised risk of pancreatic cancer compared to women, which has partly been attributed to higher rates of smoking among men.

Wednesday, 8 February 2012

Avoid Window Seats when Flying

Avoid Window Seats to Cut Risk for In-Flight Blood Clots: Study

TUESDAY, Feb. 7 (HealthDay News) -- Potentially dangerous blood clots in the legs known as deep venous thromboses (DVTs) got the nickname "economy class syndrome" from widely publicized incidents involving passengers on long-haul flights.

However, new guidelines from a leading physicians' group suggest the class you sit in on a plane may not raise your DVT risk, but your proximity to the aisle might.

Sitting in a window seat is a risk factor for DVT, the American College of Chest Physicians (ACCP) warn in their new advisory, regardless of whether it's in economy or first class.

"DVT risk has nothing to do with economy class," said Dr. Gordon H. Guyatt, chair of the ACCP panel that drafted the new guidelines. "Really, the evidence is that actually where you sit isn't really an issue. It's how much you move around. And if you're in a window seat you are probably more willing to sit for long periods of time being uncomfortable because you are reluctant to make anybody else move to let you out."

The new recommendations are published in the February issue of CHEST.

DVTs are blood clots that typically occur in the legs. They can become especially dangerous if they travel through the bloodstream to the lungs, where they can form potentially lethal pulmonary embolisms.

The current guidelines, which are endorsed by a wide range of American medical associations, are the ninth in a series of ACCP updates on the issue. They were drafted after the panel extensively reviewed findings from relevant studies published since the last update in 2008.

Long-haul immobility does boost DVT risk, the experts noted. But as the ACCP panel sifted through the evidence, they found no basis for the notion of "economy class syndrome." Rather, folks in a window seat might be more hesitant to get up and move around -- and that might raise their odds for a DVT.

Still, "the first thing to say is that if you are a healthy person you should not really worry about DVT because your risk -- even on a long-term flight -- is considerably less than one in a thousand," said Guyatt, who is also professor in the department of clinical epidemiology and biostatistics at McMaster University in Hamilton, Ontario, Canada. "So these guidelines are for those who have more than a normal risk. For those who have had a clot before, or an abnormality of their coagulation system, or disability that affects mobility. Or if you are obese or have active cancer."

In addition to those risk factors, the ACCP says that air passengers who are elderly, pregnant, take supplementary estrogen (including oral contraceptives) or recently underwent surgery and/or trauma also face a higher-than-normal risk for DVT.

Apart from seating considerations, the guidelines also suggest that people on flights lasting six or more hours move about frequently and stretch their calf muscles.

Higher-risk individuals should also wear graduated compression stockings that stretch below the knee. Guyatt said it "would be crazy" for passengers at normal risk to wear such stockings, and the ACCP guidelines specifically argue against their use by healthy passengers.

The guidelines also generally discourage the taking of aspirin and/or anticoagulant medications for the specific intent of lowering DVT risk. That said, those at very high risk are encouraged to consult their doctors in order to weigh the pros and cons of such drugs.

For his part, Dr. Christopher Cannon, a cardiologist at Brigham and Women's Hospital in Boston, said the new DVT guidelines "make obvious good sense."

"Getting up once every hour or two during a long flight and walking up and down the aisle is what you want to do," he noted. "It's not about class and the slight extra room you'll get in business. It's about sitting by the window and looking over at the guy sleeping next to you and thinking you'll wait rather than get up. That's the issue."

"I would also add that all of this would also apply to people taking long car trips," Cannon said. "I've had tons of people driving home on long car rides who have had problems with DVT. Hence the emphasis on mobility. It's all about making sure you get up or get out and move."

More information
Find out more about DVT risk at the U.S. National Library of Medicine.