Pages

Showing posts with label Covid Zero. Show all posts
Showing posts with label Covid Zero. Show all posts

Wednesday, 27 July 2022

Scientist at forefront of China's early investigations into Covid-19 steps down

 By Simone McCarthy

Updated 0940 GMT (1740 HKT) July 27, 2022




George Gao, now former head of the Chinese Center for Disease Control and Prevention, attending a forum in Beijing last year.

A version of this story appeared in CNN's Meanwhile in China newsletter, a three-times-a-week update exploring what you need to know about the country's rise and how it impacts the world. Sign up here.

https://edition.cnn.com/2022/07/27/china/china-cdc-director-george-gao-fu-covid-intl-hnk-mic/index.html


(CNN)George Gao, head of the Chinese Center for Disease Control and Prevention, has stepped down after five years at the helm of the health body, ending a tenure that placed him at the fore of early investigations into the first outbreak of Covid-19 in central China and the country's rapid development of Covid-19 vaccines.
The leadership change, announced by the agency on Tuesday, comes amid a restructuring that has seen the China CDC moved from its position directly under the monolithic centrally controlled National Health Commission and placed within a new nominally streamlined bureau, borne of pandemic-era calls for reform.
It also comes as China continues to grapple with fresh outbreaks of Covid-19 across the country, despite a stringent zero-Covid policy that has seen it maintain tight border controls and implement frequent mass testing and lockdowns.
    Oxford University-educated and internationally connected Gao, 60, known also by his Chinese name Gao Fu, would no longer serve as director "due to his age," according to the China CDC readout of a meeting announcing the changes. Sixty is a standard retirement age for male civil servants, though many do not adhere to this.
      He would be succeeded by former president of the Nanjing Medical University Shen Hongbing, currently vice-director of the National Administration of Disease Prevention and Control, the new bureau established in 2021.
      The shift brings to an end the tenure of an internationally respected virologist who observers say grappled with the limitations of an agency with little sway over policy-making -- a key distinction between China's CDC and the US agency it was modeled after.

      Legacy of an overseas-educated virologist

      Gao also oversaw the agency at a time of increasing acrimony between China and the United States, made worse by questions over the origins of the coronavirus and accusations that China had suppressed its investigation.
      Gao, who gave presentations at international scientific forums in English and had professional relationships with Western scientists, including top American epidemiologist Anthony Fauci, was widely respected among the international scientific community and seen as a rare point of contact with China.
      "He will be remembered for being more open-minded and willing to reach out to his counterparts in Western countries," said Yanzhong Huang, a senior fellow for global health at the Council on Foreign Relations in New York.
      "Under him the China CDC became a more prominent actor in China's response to the pandemic, especially in the early stages of the outbreak, and also an important window for the outside world to learn about China's Covid response," Huang said.
      Prior to the pandemic, Gao was known for his work in Sierra Leone countering a 2014 Ebola outbreak, when he was still deputy director of the China CDC. He took up the director role in 2017.
      Gao was among a group of top-level health officials who traveled to Wuhan, the epicenter of the first known outbreak of Covid-19, before the disease became a global crisis in January, 2020. China has been criticized for its actions during that period, due to the three-week lag between local officials' announcement of the outbreak and confirmation the virus could pass between people.
      Gao played a key role in early scientific papers documenting the outbreak in Wuhan, and went on to develop one of the seven Covid-19 vaccines authorized for use in China.
      He has also been involved in research into the origins of the virus, suggesting, contrary to recently published studies, that a Wuhan market linked to early cases was not where the new virus emerged, but rather a place where it was able to spread rapidly between people.
      But he has sparked controversy within China and is considered by some in China's public health community as a "loose cannon," according to Huang.
      In one instance last year, Gao appeared to suggest during a presentation that China's homegrown vaccines offered a low protection rate -- comments he later walked back in an interview with state media in which he called this a "misunderstanding" of his point.
      He was also criticized after an interview last fall with the editor of Caijing magazine, in which he discussed the conditions under which China might relax its zero-Covid policy -- a sensitive subject in China, where the policy is viewed as the personal directive of leader Xi Jinping.
      On Tuesday, Gao, who remains vice-president of China's grant-giving National Natural Science Foundation, said he supported the changes and that he would "continue contributing to developing disease control and public health."

      Virus flare-ups

      Gao's departure was announced as China continues to grapple with flare-ups of the virus, relying on frequent mass testing and snap lockdowns to handle outbreaks, while most of the rest of the world has moved into some mode of living with the virus.
      As of Wednesday, China has identified 776 high-risk areas in 24 cities across the country, where residents are subject to partial or full lockdowns, according to information from the country's State Council.
      Authorities in Wuhan, which was locked down for more than two months in early 2020, announced Wednesday they would be implementing control measures for three days in the main urban area of Jiangxia district, banning its roughly 1 million residents from leaving the area and shuttering a number of businesses and public transportation. Four cases had been identified in the district the previous day, according to official reports.
      But as the head of China CDC, Gao himself had a limited role in forming policy to respond to and control the virus, observers say, as such matters are dictated by the cabinet-level National Health Commission, while the CDC has played a more technical, advisory role.
      "Though restricted, (Gao) still tried his best to fulfill CDC's role as a public health and scientific adviser," said Xi Chen, an associate professor at the Yale School of Public Health.
      "His scientific publications in the early stage of the pandemic helped inform the world about the virus. He also championed the publication of a scientific journal in English -- China CDC Weekly -- that aimed to make communications with the global public health arena more timely and transparent."
      It remains unclear exactly what role the agency will play now that it is under the National Administration of Disease Prevention and Control. That body was set up following calls to strengthen China's disease prevention and control systems in the wake of the Covid-19 outbreak.
        In Tuesday's meeting, Wang Hesheng, head of the National Administration of Disease Prevention and Control, praised Gao's contributions and laid out several goals regarding "reform" of the CDC and its operations under the new leadership. These included taking a "clear stand on politics" and to "faithfully implement General Secretary Xi Jinping's important directives and instructions."
        And as a result of the new structure, it is possible that Gao's successor could be given more power, according to Chen. "Hopefully, the empowerment of China CDC under Shen may achieve something George Gao was unable to," he said.

        https://edition.cnn.com/2022/07/27/china/china-cdc-director-george-gao-fu-covid-intl-hnk-mic/index.html


        Wednesday, 27 April 2022

        China’s Biggest Covid Failure Is Not Deploying an mRNA Vaccine

         Beijing refuses to allow Western shots even though development of homegrown ones lags.

        Covid vaccination at a mobile site in Beijing on April 9.
        Covid vaccination at a mobile site in Beijing on April 9.Photographer: Chen Zhonghao/Xinhua News Agency/eyevine/Redux

         Weeks into a Covid-19 outbreak in Shanghai that brought China’s financial hub to a standstill, the government of President Xi Jinping has demonstrated its willing to go to extremes in its quest to contain the virus. One thing Xi has so far been unwilling to do is deploy a powerful tool against the highly contagious omicron variant: mRNA vaccines. Those shots could reduce the chances of elderly and other vulnerable Chinese getting seriously ill or dying—and possibly help the country transition away from its “Covid Zero” stance.

        Lining up the necessary supplies shouldn’t be hard because Shanghai Fosun Pharmaceutical Group Co. in March 2020 agreed to buy a stake of 0.7% in BioNTech SE and to market the mRNA vaccine the German company co-developed with Pfizer Inc. in China. Before the close of that same year, the two companies had arrived at a plan to distribute 100 million doses in China, once they got the green light from the government. Yet the drug regulator has yet to grant approval.

        “Worldwide data clearly indicates mRNA is the gold standard,” says Joerg Wuttke, president of the European Union Chamber of Commerce in China, which wrote to the Chinese government in April urging it to allow the shots. “Why waste time and wait, for what?”

        Share of Population Fully Vaccinated Against Covid-19

        As of April 24

        Source: Compiled by Bloomberg

        The wait, many analysts believe, is for a local company to come up with its own mRNA vaccine. Since the start of the pandemic, Xi’s government has touted self-reliance in fighting Covid, promoting domestic vaccines based on inactivated versions of the virus and barring all foreign ones from the market. Slightly more than 88% of China’s 1.4 billion people have received two doses of those shots.

        Opening up to foreign-made mRNA shots risks embarrassing Xi and other officials, says Allison Hills, senior consultant in London with Eradigm Consulting, which advises biotech and pharmaceutical clients. “For them to say now we are accepting BioNTech,” she says, “it’s tantamount to saying ours are not as good.”

        Clinical trials have shown the inactivated vaccines from China’s Sinopharm Group Co. and Sinovac Biotech Ltd. to be less effective in stopping infections, though the gap in protecting against severe disease and death is narrower.

        Last year, optimists hoped China’s go-it-alone strategy would lead to the speedy approval of a locally made mRNA vaccine, co-developed by Walvax Biotechnology Co., Suzhou Abogen Bioscience Co., and the Academy of Military Medical Sciences. Upbeat about their chances, the partners invested in a new facility to ramp up production once Beijing gave the green light, with state media reporting production would start by August 2021. However, results of early trials were disappointing and the vaccine is unlikely to reach the market before the end of 2022, according to Bloomberg Intelligence.


        relates to China’s Biggest Covid Failure Is Not Deploying an mRNA Vaccine
        An exhibitor shows two packets of an mRNA vaccine co-developed by Walvax Biotechnology at the China International Technology Fair in Shanghai in April 2021.
        Photographer: FeatureChina/AP Photo

        One reason for the delay could be the different approach the Walvax group took. Unlike the shots from Pfizer-BioNTech and Moderna Inc., the Chinese vaccine targets a part of the coronavirus spike protein that binds to cells in the body, according to Sam Fazeli, senior pharmaceutical analyst with Bloomberg Intelligence in London. For vaccine developers, focusing on this smaller area, called the receptor binding domain, can reduce costs and may facilitate manufacturing. It can also add uncertainty, given that this particular domain is a focal point for mutations in newer variants.

        “Walvax’s problem is the majority of the mutations with omicron are in that receptor binding domain,” says Fazeli. “The risk is that their vaccine’s efficacy is likely to be much more compromised compared to other vaccines.”

        Walvax, which didn’t respond to a request for comment regarding the design of the mRNA vaccine it co-developed with Abogen, says it has partnered with a Shanghai-based biotech startup called RNACure Biopharma to develop another mRNA vaccine targeting variants, including omicron. This one encodes a full-length spike protein that covers major mutations from variants. The companies are seeking approvals to begin human testing.

        Walvax’s difficulties have raised the stakes for other Chinese companies working on vaccines using the same technology. In early April, China gave permission for CanSino Biologics Inc. and CSPC Pharmaceutical Group Ltd. to each begin first-phase trials for their mRNA shots.

        Other drugmakers are further along: Shanghai-based Stemirna Therapeutics Co. has tested an mRNA candidate in Laos and plans further testing in Brazil. It hopes to get emergency-use approval in Southeast Asia and South America. Beijing-based AIM Vaccine Co., which has a Phase 2 trial of its mRNA vaccine under way in China, expects to apply for conditional approval by the end of the year, according to spokesperson Lingna Ding.

        Read more: China Crushed Covid. But Covid Zero Could Crush China

        Early data from Hong Kong’s winter omicron wave show why mRNA vaccines could be valuable in China. A preprint study by researchers at the University of Hong Kong in late March concluded that two doses of the Sinovac vaccine underperformed BioNTech’s shots, especially among the elderly. For prevention of severe disease, BioNTech’s vaccine effectiveness in people 80 and older was 84.5%, compared with just 60.2% for Sinovac; for protection against death, there was a gap of about 20 percentage points, with BioNTech at 88.2% and Sinovac at 66.8%.

        The study, which was funded by the Chinese government, found no significant gap for those who had received three doses. That cohort, however, was small, as only about 10% of seniors had received boosters and government vaccination teams dispatched to nursing homes—sites of the worst outbreaks—only offered Sinovac shots.

        Another study by Hong Kong researchers, published in January in the journal Nature, concluded that governments primarily using Sinovac’s vaccines should consider mRNA vaccine boosters in response to the spread of omicron.

        Given the strong performance of mRNA vaccines, providing them as boosters should help people who have received two doses of Chinese shots, says Jyoti Somani, senior consultant for the Division of Infectious Diseases at National University Hospital in Singapore, where the government has approved China’s inactivated-virus vaccines as well as mRNA shots developed elsewhere. “It looks like you are getting a much broader immune response when you mix and match,” she says. “What is clear is that we need both.”

        That argument is winning support inside China. Zhong Nanshan, a pulmonologist and influential government adviser on Covid, in March co-authored a road map for China’s reopening that identified better booster coverage, with different vaccine types, as essential. Ding Sheng, dean of Tsinghua University’s School of Pharmaceutical Sciences, in March said that existing Chinese vaccines weren’t protective enough against omicron and that the government should encourage companies to introduce more effective shots.

        Fosun’s chief executive officer, Wu Yifang, told reporters at a briefing on March 23 that China’s drug regulator is still weighing whether to approve the BioNTech shot. Authorities in February gave the green light to Pfizer’s antiviral treatment, Paxlovid, filling a need because Chinese drugmakers don’t have any antivirals of their own. In the same way, regulators might eventually lose patience with Chinese vaccine makers and open the door to BioNTech’s shots.

        With no mRNA vaccines of any kind on the horizon, Chinese health officials may have to focus on better deploying the shots now available, targeting vaccine holdouts, especially among seniors, and improving booster rates. Approximately half the population has received booster shots. That compares with about 30% in the U.S. “Any of the vaccines would be a good thing,” says Colin Pouton, a professor at the Monash Institute of Pharmaceutical Sciences in Melbourne.

        The Covid Zero policy is making that more difficult, with millions of residents stuck in their homes in Shanghai and other cities. “We have economic damage, we have social tension, we have basically a whack-a-mole outlook,” says Wuttke. “Two years have passed and China has no mRNA vaccines to offer.” —Bruce Einhorn 

        https://www.bloomberg.com/news/articles/2022-04-26/china-covid-situation-worsened-by-lack-of-local-mrna-vaccine


        https://healthticket.blogspot.com/2022/05/chinas-bet-on-homegrown-mrna-vaccines.html

        https://healthticket.blogspot.com/2022/04/chinas-biggest-covid-failure-is-not.html

        https://arisechina.blogspot.com/2022/01/china-has-rejected-worlds-top-mrna.html

        https://arisechina.blogspot.com/2022/01/china-rushes-to-develop-mrna-covid-19.html

        https://healthticket.blogspot.com/2021/05/15-apr-21-how-china-passed-up-vaccine.html

        https://healthticket.blogspot.com/2021/05/top-chinese-official-admits-vaccines.html


        Friday, 1 April 2022

        China Crushed Covid. But Covid Zero Could Crush China

        A new wave of infections is highlighting the growing cost of China’s zero-tolerance virus policy

        Updated on


        Workers from a public service organization deliver vegetables to residents of a Shanghai neighborhood in lockdown on March 29. Photographer: Hector Retamal/AFP/Getty Images


        China’s Covid Zero strategy has been drastic and effective, saving lives and keeping the economy on track. But a new wave of virus cases is highlighting the growing costs of that approach – as well as the perils of any attempt to change it. 

        Authorities are fighting to curb the spread of the omicron variant among a population that lacks natural immunity and only has access to home-grown vaccines that are less effective than some of the global alternatives. Shanghai – the country’s financial center – is locking down just weeks after the technology hub of Shenzhen was forced to do so.

        For the rest of the article refer to the link below ...

        Source:

        https://www.bloomberg.com/news/features/2022-03-31/china-s-covid-zero-strategy-what-could-xi-jinping-do-next

        Wednesday, 26 January 2022

        China has rejected the world’s top mRNA vaccines. Now, it’s making its own

        Until now, China has rejected the world's most effective and popular COVID-19 vaccine technology ...


        Until now, China has rejected the world's most effective and popular COVID-19 vaccine technology—mRNA jabs—and has instead relied on traditional, inactivated vaccines to achieve its 86.6% fully vaccinated rate. But inactivated vaccines are less effective against Omicron and, analysts suspect, China's exclusive use of the old tech is the primary reason why China's borders remain mostly sealed to the outside world.

        But this week a Chinese pharmaceutical company announced it is getting closer to developing a homegrown mRNA vaccine, which may prove a critical step in Beijing accepting the technology, providing a much-needed immunity boost to its 1.4 billion population, and finally reopening its borders.

        On Monday, Chinese vaccine maker Walvax Biotech published Phase I clinical data on China’s first homegrown mRNA vaccine showing that the vaccine induced an immune response. Walvax is jointly developing the vaccine with private vaccine maker Suzhou Abogen Biosciences and the Chinese military’s Academy of Military Science, and published the peer-reviewed study in The Lancet medical journal.

        In the study, Walvax gave six different groups of 20 people two jabs 28 days apart. One group received a placebo, while the other groups received differing doses—5, 10, 15, 20, or 25 micrograms—of the vaccine to gauge the intensity of immune responses.

        The results showed the mRNA jab has an efficacy between 80% and 95%, which is on par with the mRNA vaccine developed by Pfizer and BioNTech—but Bloomberg Intelligence analyst Mia He says those early figures don't tell the whole story.

        For one, He told Bloomberg, the Walvax vaccine appears to be more effective in generating antibodies than actually catching the virus when administered in certain concentrations. That finding suggests that unless dosing is extremely precise, getting the jab may not provide more protection than getting COVID-19. Other mRNA vaccines, like BioNTech's, don't have that problem.

        Plus, the Walvax vaccine appears to cause more side effects, such as fevers, than Pfizer’s or Moderna’s shots do. But the study remains the first clinical proof that China may have a viable homegrown mRNA jab to distribute to its population.

        Chinese authorities, meanwhile, appear to have iced out the country's other mRNA option: the BioNTech jab.

        Since March 2020, China’s Fosun Pharma has partnered with Germany’s BioNTech to market and distribute the proven and highly effective mRNA jab in the Chinese market. (Pfizer, which struck an agreement with BioNTech after Fosun did, controls distribution rights to BioNTech’s vaccine in most other countries.)

        Fosun Pharma has already distributed jabs to places where it controls distribution rights, including Hong Kong, Macau, and Taiwan, and has reportedly built manufacturing facilities to produce the mRNA vaccine in mainland China.

        But Beijing has yet to approve the vaccine for distribution in mainland China, despite BioNTech's mRNA shot being more effective than the inactivated vaccines from makers like Sinopharm and Sinovac that China is currently distributing to its citizens.

        Last July, when Walvax's drug was still in development, the company's director of research development, Dr. Tong Xin, told Fortune he was optimistic that an mRNA jab would eventually launch in China because "the vaccine technology has been proved effective." But Walvax still has a long way to go before it can bring its drug to market.

        Walvax reports it is currently conducting Phase III clinical trial for its vaccine in Mexico and Indonesia, but it is still recruiting the volunteers it needs to carry out the tests. Finding volunteers is increasingly difficult as global vaccination rates have increased since the pandemic began. The trial requires unvaccinated test subjects.

        The stakes may be high for Walvax to complete its trials soon and begin rolling out the jabs.

        On Wednesday, Bloomberg reported that Hong Kong’s European Chamber of Commerce expects mainland China—and Hong Kong by proxy—to remain closed off from the world until the country starts administering an mRNA vaccine as a booster to its 1.4 billion citizens. The chamber believes that China may only feel confident in opening its borders once citizens can get boosted with more effective mRNA vaccines.

        But the chamber said it expects that process of boosting citizens with mRNA shots to take up to two years, with China and Hong Kong potentially remaining closed until the spring of 2024.

        Source:

        https://fortune.com/2022/01/26/china-covid-vaccine-mrna-homegrown-walvax-reopen-borders/


        Other reads:

        https://healthticket.blogspot.com/2022/05/chinas-bet-on-homegrown-mrna-vaccines.html

        https://healthticket.blogspot.com/2022/04/chinas-biggest-covid-failure-is-not.html

        https://arisechina.blogspot.com/2022/01/china-has-rejected-worlds-top-mrna.html

        https://arisechina.blogspot.com/2022/01/china-rushes-to-develop-mrna-covid-19.html

        https://healthticket.blogspot.com/2021/05/15-apr-21-how-china-passed-up-vaccine.html

        https://healthticket.blogspot.com/2021/05/top-chinese-official-admits-vaccines.html


        Related Articles