By Robin Wulffson
MD on February 16, 2012 - 2:09pm for eMaxHealth
COPENHAGEN, DENMARK - All individuals age; however, some age more rapidly
than others. Although this is partly due to genetics, environmental factors and
lifestyle choices, such as smoking and obesity, play a role. In addition, poor
lifestyle choices increase the risk of heart attacks and early death.
Chromosomes, which are contained in the cell nucleus, contain telomeres,
which are a sequence of DNA material at the end of the chromosome. Telomeres
protect the end of the chromosome from deterioration or from fusion with
neighboring chromosomes. These telomeres shorten over time; however, smoking,
obesity, and other poor lifestyle choices accelerate the process.
For decades, scientists have theorized that the shortening of telomeres
increases the risk of heart attack and early death. According to a large new
study, a direct link exists between these poor lifestyle choices and cellular
health. In addition, the study provides methodology to evaluate an individual’s
cellular health.
A research team led by Professor of Genetic Epidemiology Borge Nordestgaard
at the University of Copenhagen used data from the Copenhagen General Population
Study, which comprised 19,838 Danes; some were followed for almost 19 years. The
researchers isolated each individual’s DNA and analyzed their specific telomere
length.
"The risk of heart attack or early death is present whether your telomeres
are shortened due to lifestyle or due to high age," noted Professor
Nordestgaard. He added, "That smoking and obesity increases the risk of heart
disease has been known for a while. We have now shown, as has been speculated,
that the increased risk is directly related to the shortening of the protective
telomeres––so you can say that smoking and obesity ages the body on a cellular
level, just as surely as the passing of time."
The researcher found that 25% of the subjects had telomeres of such a short
length that not only would they statistically die prematurely but also have an
almost 50% increase in the risk of a heart attack. Professor Nordestgaard said,
"Future studies will have to reveal the actual molecular mechanism by which the
short telomere length causes heart attacks." He posed the question, "Does one
cause the other or is the telomere length and the coronary event both indicative
of a third–– yet unknown ––mechanism?"
A possible major benefit of the study is that the blood tests used by the
researchers could be conducted in the clinical situation. Physicians could order
simple blood tests, which would reveal the patient’s telomere length; thus,
determining cellular wear and age.
The study "Short Telomere Length, Myocardial Infarction, Ischemic Heart
Disease, and Early Death ” is currently available online at this
link. It is scheduled for publication in the March issue of the journal
Arteriosclerosis, Thrombosis and Vascular Biology published by the American
Heart Association.
Coronary heart disease is responsible for almost 25% of deaths in the United
States and is the leading cause of death for both men and women. Every year
about 785,000 Americans suffer their first heart attack. Another 470,000 who
have already suffered one or more heart attacks have another attack.
http://www.emaxhealth.com/11306/cellular-aging-linked-heart-attacks-and-early-death