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Two years ago, a study known as the JUPITER trial suggested the cholesterol-lowering statin drug might prevent heart-related death in many more people than just those with high cholesterol.
Now, however, researchers say that the JUPITER results are flawed -- and that they do not support the benefits initially reported.
Not only is there no "striking decrease in coronary heart disease complications", but a new report has also called into question drug companies' involvement in such trials.
ABC News reports:
Now, however, researchers say that the JUPITER results are flawed -- and that they do not support the benefits initially reported.
Not only is there no "striking decrease in coronary heart disease complications", but a new report has also called into question drug companies' involvement in such trials.
ABC News reports:
"... major discrepancies exists between the significant reductions in nonfatal stroke and heart attacks reported in the JUPITER trial and what has been found in other research ... 'The JUPITER data set appears biased,' [the researchers] wrote in conclusion."
Dr. Mercola's Comments: |
Tens of millions of Americans are taking cholesterol-lowering drugs—mostly statins—and some "experts" claim that many millions more should be taking them.
I couldn't disagree more.
Statins are HMG-CoA reductase inhibitors, that is, they act by blocking the enzyme in your liver that is responsible for making cholesterol (HMG-CoA reductase). The fact that statin drugs cause side effects is well established—there are now 900 studies proving their adverse effects, which run the gamut from muscle problems to increased cancer risk.
For starters, reported side effects include:
- Muscle problems, polyneuropathy (nerve damage in the hands and feet), and rhabdomyolysis (a serious degenerative muscle tissue condition)
- Anemia
- Acidosis
- Sexual dysfunction
- Immune depression
- Pancreas or liver dysfunction, including a potential increase in liver enzymes
- Cataracts
Muscle problems are the best known of statin drugs' adverse side effects, but cognitive problems and memory loss are also widely reported. A spectrum of other problems, ranging from blood glucose elevations to tendon problems, can also occur. There is evidence that taking statins may even increase your risk for Lou Gehrig's disease.
Statins currently available on the U.S. market are:
- Advicor (lovastatin with niacin) – Abbott
- Altoprev (lovastatin) – Shionogi Pharma
- Caduet [atorvastatin with amlodipine (Norvasc)] – Pfizer
- Crestor (rosuvastatin) - AstraZeneca
- Lescol (fluvastatin) – Novartis
- Lipitor (atorvastatin) - Pfizer
- Mevacor (lovastatin) – Merck
- Pravachol (pravastatin) -- Bristol-Myers Squibb
- Simcor (niacin/imvastatin) – Abbott
- Vytorin (ezetimibe/simvastatin) – Merck/Schering-Plough
- Zocor (simvastatin) – Merck
Ninety-Nine Out of 100 People do Not Need Statin Drugs
That these drugs have proliferated the market the way they have is a testimony to the power of marketing, corruption and corporate greed, because the odds are very high— greater than 100 to 1—that if you're taking a statin, you don't really need it.
The ONLY subgroup that might benefit are those born with a genetic defect called familial hypercholesterolemia, as this makes them resistant to traditional measures of normalizing cholesterol.
And, even more importantly, cholesterol is NOT the cause of heart disease.
If your physician is urging you to check your total cholesterol, then you should know that this test will tell you virtually nothing about your risk of heart disease, unless it is 330 or higher.
HDL percentage is a far more potent indicator for heart disease risk. Here are the two ratios you should pay attention to:
I have seen a number of people with total cholesterol levels over 250 who were actually at low risk for heart disease due to their elevated HDL levels. Conversely, I have seen many people with cholesterol levels under 200 who had a very high risk of heart disease, based on their low HDL.
- HDL/Total Cholesterol Ratio: Should ideally be above 24 percent. If below 10 percent, you have a significantly elevated risk for heart disease.
- Triglyceride/HDL Ratio: Should be below 2.
Your body NEEDS cholesterol—it is important in the production of cell membranes, hormones, vitamin D and bile acids that help you to digest fat. Cholesterol also helps your brain form memories and is vital to your neurological function.
There is also strong evidence that having too little cholesterol INCREASES your risk for cancer, memory loss, Parkinson's disease, hormonal imbalances, stroke, depression, suicide, and violent behavior.
Parents Beware: Outrageous New Push to Put Kids on Statin Drugs!
In a bold attempt to increase profits before the patent runs out, Pfizer has now introduced a chewable kid-friendly version of Lipitor. Its US patent for Lipitor expires in November 2011, and seeking to boost sales of the drug, children have become the new target market, and the conventional medical establishment is more than happy to oblige.
Researchers and many doctors are now calling for universal school screening of children to check for high cholesterol, to find those "in need of treatment." In addition, older siblings, parents and other family members might be prompted to get screened as well, the researchers say, which would uncover additional, previously undiagnosed adults in need of the drug.
This is clearly NOT the way to improve public health. On the contrary, it could produce a new, massive wave of extremely dire health consequences in just a few years time.
So rather than improving school lunches, which would cost about a dollar a day per child, they'd rather "invest" ten times that for tests and drugs that in no way, shape, or form address the root cause, which is an improper, unhealthy diet!
All they're doing is allowing all the industries to maintain or increase their profits: Big Pharma; Big Sugar; Big Corn and the processed food industry.
Who pays?
You, and your children! And in far more ways than one!
I will address this issue in depth in a future article, so please stay tuned…
If You Take Statins, You MUST Take CoQ10
If you take statin drugs without taking CoQ10, your health is at serious risk. Unfortunately, this describes the majority of people who take them in the United States.
CoQ10 is a cofactor (co-enzyme) that is essential for the creation of ATP molecules, which you need for cellular energy production. Organs such as your heart have higher energy requirements, and therefore require more CoQ10 to function properly.
Statins deplete your body of CoQ10, which can have devastating results.
Physicians rarely inform people of this risk and only occasionally advise them to take a CoQ10 supplement. As your body gets more and more depleted of CoQ10, you may suffer from fatigue, muscle weakness and soreness, and eventually heart failure.
Coenzyme Q10 is also very important in the process of neutralizing free radicals. So when your CoQ10 is depleted, you enter a vicious cycle of increased free radicals, loss of cellular energy, and damaged mitochondrial DNA.
If you decide to take a CoQ10 supplement and are over the age of 40, it is important to choose the reduced version, called ubiquinol. Ubiquinol is a FAR more effective form—I personally take 1-3 a day since it has such far ranging benefits.
Optimizing Your Cholesterol Levels, Naturally
There's really no reason to take statins and suffer the damaging health effects from these dangerous drugs.
The fact is that 75 percent of your cholesterol is produced by your liver, which is influenced by your insulin levels. Therefore, if you optimize your insulin level, you will automatically optimize your cholesterol.
It follows, then, that my primary recommendations for safely regulating your cholesterol have to do with modifying your diet and lifestyle:
Unlike statin drugs, which lower your cholesterol at the expense of your health, these lifestyle strategies represent a holistic approach that will benefit your overall health—which includes a healthy cardiovascular system.
- Reduce, with the plan of eliminating, grains and sugars in your diet. Eat the right foods for your nutritional type, and consume a good portion of your food raw.
- Make sure you are getting plenty of high quality, animal-based omega 3 fats, such as krill oil.
- Other heart-healthy foods include olive oil, coconut and coconut oil, organic raw dairy products and eggs, avocados, raw nuts and seeds, and organic grass-fed meats as appropriate for your nutritional type.
- Exercise daily. Make sure you incorporate peak fitness exercises, which also optimizes your human growth hormone (HGH) production.
- Address your emotional challenges. My favorite technique for stress management is the Emotional Freedom Technique (EFT).
- Avoid smoking or drinking alcohol excessively.
- Be sure to get plenty of good, restorative sleep.
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Statin Drugs do NOT Prevent Cancer
It has now been conclusively shown that the cholesterol-lowering drugs have no effect whatsoever on cancer, despite previous arguments to the contrary.
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Crestor and Other Statins: Are They Really Worth the Risk?
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The Baycol Statin Recall and Safety Issue:
In August 2001, Bayer AG, the maker of Baycol (cerivastatin), a popular cholesterol-lowering drug used by about 700,000 Americans, pulled the medicine off the market after 31 people died from severe muscle breakdown, a well-recognized side effect of cholesterol-lowering drugs. Related articles follow:
Statins: Is the Danger in the Dose?Here is the hard data on Baycol-associated adverse reactions. If you or someone you know is taking one of the statin cholesterol-lowering drugs, this is a "must-read" article by Jay Cohen, MD to help you understand the potential dangers that this exposes you to.
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Excerpts from Public Citizen's Health Research Group's Petition to Require a Box Warning on All HMG-CoA Reductase Inhibitors ("Statins"):
" ... Public Citizen, representing 135,000 consumers nationwide, hereby petitions the FDA pursuant to the Federal Food, Drug and Cosmetic Act 21, U.S.C. Section 355(e)(3), and C.F.R. 10.30, to add a black box warning and additional consistent bolded warnings about this serious problem to the label of all statins marketed in the United States."
"Doctors and the public must be warned to immediately discontinue use of statin drugs at the onset of muscle pain, muscle tenderness, muscle weakness or tiredness."
"Prompt cessation of the use of statins at the first sign of muscle pain, muscle tenderness, muscle weakness or tiredness and prompt evaluation by a physician including a blood test for creatine phosphokinase (a measure of muscle destruction) may avoid the progression to more extensive muscle damage, rhabdomyolysis and death."
"Rhabdomyolysis has been reported with all statins currently marketed in the United States."
About the Experts
Joseph Mercola, DO
Medical Director of the Natural Health Center and Mercola.com. Read about my complete background information.Uffe Ravnskov, MD
Born 1934 in Copenhagen, Denmark Graduated 1961 from the University of Copenhagen with an M.D. 1961-1967: Various appointments at surgical, roentgenological, neurological, pediatric and medical departments in Denmark and Sweden. 1968-1979: Various appointments at the Department of Nephrology, and the Department of Clinical Chemistry, University Hospital, Lund, Sweden. 1975-79: As an assistant professor at the Department of Nephrology. 1973: PhD at the University of Lund. 1979-2000: A private practitioner. Since 1979 an independent researcher. A specialist in internal medicine and nephrology. Honored by the Skrabanek Award 1998.Jay Cohen, M.D
For more information about him, see Dr. Ravnskov's Web site.
Jay Cohen, M.D., is an associate professor of Family and Preventative Medicine and of Psychiatry at the University of California in San Diego. He is the author of two books and has numerous papers published in peer-reviewed journals. His book, Over Dose: The Case Against the Drug Companies, is an outstanding read.
Source:ABC News June 29, 2010
Source:Video Transcript
