Monday, 22 June 2020

Vitamin D Supplementation Recommended to Quell Mortality - Covid-19

The Most Important Paper Dr. Mercola Has Ever Written

Analysis by Dr. Joseph MercolaFact Checked

STORY AT-A-GLANCE

Vitamin D optimization is likely the easiest, least expensive and most beneficial strategy that anyone can do to minimize their risk of COVID-19 and other infections in coming months
More than 1 billion individuals worldwide, across all age groups, are deficient in vitamin D, which has now been identified as a significant risk factor for positive COVID-19 status, severe COVID-19 infection and death thereof
In Indonesia, people with a vitamin D level between 20 ng/mL and 30 ng/mL had a sevenfold higher risk of death than those with a level above 30 ng/mL. Having a level below 20 ng/mL was associated with a 12 times higher risk of death
To improve your immune function and lower your risk of viral infections, you’ll want to raise your vitamin D to a level between 60 ng/mL and 80 ng/mL (150 nmol/L and 200 nmol/L) by fall
Vitamin D optimization is particularly important for dark-skinned individuals, as the darker your skin, the more sun exposure you need to raise your vitamin D level, as well as the elderly

All things considered, vitamin D optimization is likely the easiest, least expensive and most beneficial strategy that anyone can do to minimize their risk of COVID-19 and other infections in the coming months. Health authorities are already warning of a second wave of COVID-19 in the fall, which means the time to start addressing your vitamin D level is NOW.

We also have a pandemic of vitamin D deficiency, as more than 1 billion individuals worldwide, across all age groups, are deficient in vitamin D.1,2,3,4 Vitamin D deficiency has now been identified as a significant risk factor for positive COVID-19 status,5,6 severe COVID-19 infection7,8,9,10 and death thereof.11,12 I discuss this in "Vitamin D Is Directly Correlated to COVID-19 Outcome."

In one study,13,14 which looked at data from 780 hospital patients in Indonesia, those with a vitamin D level between 20 nanograms per milliliter (ng/mL) and 30 ng/mL had a sevenfold higher risk of death than those with a level above 30 ng/mL. Having a level below 20 ng/mL was associated with a 12 times higher risk of death.

To improve your immune function and lower your risk of viral infections, you'll want to raise your vitamin D to a level between 60 ng/mL and 80 ng/mL by fall. In Europe, the measurements you're looking for are 150 nmol/L and 200 nmol/L. If vitamin D levels were increased in the global population, tens of thousands of people may be saved if or when COVID-19 reemerges.

While prospective controlled studies demonstrating vitamin D's effectiveness in COVID-19 are still lacking, there are many such studies underway. You can review the status of these trials on clinicaltrials.gov.15 As of early June 2020, more than 20 studies had been launched to investigate the benefits of vitamin D against COVID-19.

The Most Important Paper I've Ever Written

For the last three weeks, I have been writing a comprehensive report on vitamin D in the prevention of COVID-19. The report has been reviewed by many vitamin D scientists for accuracy. This was done to develop a resource that everyone can share to help educate others. We will soon be launching a campaign to educate and inspire everyone, everywhere, to start optimizing their vitamin D level NOW. Please download my paper here, and share it with everyone you know.

The purpose of this report is to help you understand why it is so important to optimize vitamin levels for healthy immune functions and then provide you with a detailed strategy of how to do that. This report can be used as a tool to teach your friends, family and community about why and how to be prepared for the next pandemic.

Mounting evidence demonstrates that vitamin D has important roles in regulating the immune system that should reduce COVID-19 risks; primarily by reducing survival and replication of the SARS-CoV-2 virus and by reducing the risks of 'cytokine storms' by reducing pro-inflammatory cytokine production and increasing anti-inflammatory cytokine production.

In it, I review the science of how your immune system works, and the regulatory role of vitamin D. I also explain how vitamin D reduces your risk of COVID-19 specifically, and how it helps suppress and control both acute respiratory distress syndrome (ARDS) and cytokine storms, which is a primary cause of death in COVID-19.

Click here to learn Dr. Mercola's top tips to combat coronavirus

Darker-Skinned Individuals Need More Vitamin D

Vitamin D optimization is particularly important for dark-skinned individuals, as the darker your skin, the more sun exposure you need to raise your vitamin D level. Increased skin pigmentation reduces the efficacy of UVB because melanin functions as a natural sunblock.

If you're very dark-skinned, you may need to spend about 1.5 hours a day in the sun to have any noticeable effect. For many working adults and school-age children, this simply isn't feasible.

Light-skinned individuals may only need 15 minutes of full sun exposure a day, which is far easier to achieve. Still, they too will typically struggle to maintain ideal levels during the winter. During the winter months at latitudes of greater than 40°, little or no UVB radiation reaches the surface of the earth. That said, residence at low latitude does not guarantee adequate vitamin D levels, since social and cultural norms may limit sun exposure.16

As noted in the MedCram video above, black, Asian and minority ethnic groups are at an increased risk of death from COVID-19. While some have blamed this racial disparity on health care access, a far more likely reason for this is because dark-skinned individuals are far more likely to be deficient in vitamin D.

In fact, the paper cited by MedCram specifically looked at ethnic disparities in COVID-19 mortality among patients in England, where health care is freely available to all, so the health care access rationale doesn't seem to hold water.

Vitamin D Supplementation Recommended to Quell Mortality

The role of vitamin D is addressed in a reply17 by vitamin D researchers William Grant and Barbara Boucher to The BMJ editorial "Is Ethnicity Linked to Incidence or Outcomes of COVID-19?" They write, in part:

"The recent BMJ editorial by Khunti et al. asks 'Is ethnicity linked to incidence or outcomes of covid-19?' Here we outline how ethnicity relates to incidence and outcomes of COVID-19 due, in part, to lack of vitamin D because of increased skin pigmentation and diet …

A potentially important factor not considered in the PHE report was vitamin D deficiency, though mounting evidence suggests that vitamin D deficiency is an important risk factor for acute respiratory tract infections and for COVID-19 …

Mounting evidence demonstrates that vitamin D has important roles in regulating the immune system that should reduce COVID-19 risks; primarily by reducing survival and replication of the SARS-CoV-2 virus and by reducing the risks of 'cytokine storms' by reducing pro-inflammatory cytokine production and increasing anti-inflammatory cytokine production.

Vitamin D also promotes local ACE2 formation in the lungs, an effect known to reduce the severity of acute respiratory distress syndrome. Furthermore, higher baseline serum 25(OH)D concentrations are currently being reported to be associated with reduced rates of severe COVID-19 and of mortality."

Grant and Boucher go on to cite data from studies reviewed in "Vitamin D Combats Viral Infections and Boosts Immune System," which features my interview with vitamin D experts Bruce Hollis, Ph.D., Carole Baggerly and Dr. Carol Wagner. All of these researchers reviewed the vitamin D report I wrote for accuracy.

Grant and Boucher recommend advising the public to supplement vitamin D daily, especially black, Asian and minority ethnic groups, indoor workers, shift workers, the elderly, those in residential care or those confined to their homes, as well as those who are obese. Doing so might reduce COVID-19 severity and prevent unnecessary deaths.

"Vitamin D is readily available … 'over the counter' at supermarkets, chemists and online, but could be provided free to those in financial hardship or unable to access supplies," Grant and Boucher write, adding:

"Doses of 1,000 IU/day in general and of 4,000 IU/day for those at high risk of deficiency, as above, including the BAME groups, should be advised for the duration of the Covid-19 outbreak …"

Sunscreen Advice Counters Lifesaving Vitamin D Message

Remarkably, while the importance of vitamin D against COVID-19 is becoming more widely recognized by doctors, some are still advising against either sun exposure or vitamin D supplementation, or both.

Some, such as Dr. Pieter Cohen, an internal medicine physician at Cambridge Health Alliance in Massachusetts and an associate professor medicine at Harvard Medical School, is even discouraging people from getting their vitamin D level tested to see if they're deficient!18 A June 1, 2020, report on Today.com states:19

"The body can manufacture vitamin D when the skin is exposed to the sun or get it from food. 'I'm not making a general recommendation for supplements. I'm saying: To avoid vitamin D deficiency.

It will usually take only being outdoors, getting incidental sun exposure, plus paying attention to the dietary sources of vitamin D,' [Dr. JoAnn Manson, chief of preventive medicine at Brigham and Women's Hospital and professor of medicine at Harvard] noted.

Incidental sun exposure means getting some sunshine during a 30-minute walk or other outdoor exercise while wearing shorts or short sleeves (though you should still use sunscreen). It doesn't mean going out specifically to sun bathe."

The advice to wear sunscreen while getting "incidental" sun exposure is medically irrational and incorrect, since sunscreen filters out the very ultraviolet rays that trigger vitamin D production in your skin.

In order for sensible sun exposure to work, you need unprotected exposure. Just make sure you don't get sunburned. All you need is to stay out until your skin turns the lightest shade of pink. After that, cover up with long sleeves and pants.

Manson is, however, starting a clinical trial to see whether taking a vitamin D supplement every day for a month after testing positive for COVID-19 might reduce the severity of any subsequent illness. The study will also assess whether vitamin D supplementation among other people in the same household might prevent them from developing COVID-19 when one family member has tested positive.20

This is one of many prospective randomized controlled studies currently in progress seeking to find scientifically determine if vitamin D does indeed reduce the risk of COVID-19. If you are curious about the status of any of these studies or potentially even enrolling in any of them you can visit this link.

Help Us Spread the Word!

It is my sincere hope and desire that all of you will help us in this effort to spread the word about vitamin D and get your friends and family on board to get their vitamin levels optimized. We need a citizen army of activists to spread the word. My vitamin D report can help you in this effort. I urge you to share it with everyone you know. I hope to collaborate with all the major natural medical sites to participate in this process.

Part of the strategy will be to share this information with influencers in the black community, such as pastors of black churches. They have the most to lose should a second wave of COVID-19 emerge because of their historically low levels of vitamin D.

It will also be important to reach out to mangers of nursing homes and assisted living facilities, as the elderly also have notoriously low vitamin D levels that put them at greater risk of COVID-19.

Remember, you now have a known "deadline" for optimizing your vitamin D level. Historically, December typically has highest flu activity in the U.S.,21 but it would probably be good to aim for October, or maybe even earlier depending on your location.

Again, the level you're aiming for is between 60 ng/mL and 80 ng/mL by fall. In Europe, the measurements you're looking for are 150 nmol/L and 200 nmol/L. In my vitamin D report, I detail how to go about doing this, but here's a quick summary of the key steps:

1.First, measure your vitamin D level — One of the easiest and most cost-effective ways of measuring your vitamin D level is to participate in the GrassrootsHealth's personalized nutrition project, which includes a vitamin D testing kit.

Once you know what your blood level is, you can assess the dose needed to maintain or improve your level. The easiest way to raise your level is by getting regular, sensible sun exposure, as discussed above.

If you cannot get enough vitamin D from the sun (you can use the DMinder app22 to see how much vitamin D your body can make depending on your location and other individual factors), then you'll need an oral supplement. As detailed in "Magnesium and K2 Optimize Your Vitamin D Supplementation," it's strongly recommended to take magnesium and K2 concomitant with oral vitamin D.

2.Assess your individualized vitamin D dosage — To do that, you can either use the chart below, or use GrassrootsHealth's Vitamin D*calculator. To convert ng/mL into the European measurement (nmol/L), simply multiply the ng/mL measurement by 2.5. To calculate how much vitamin D you may be getting from regular sun exposure in addition to your supplemental intake, use the DMinder app.23

3.Retest in three to six months — Lastly, you'll need to remeasure your vitamin D level in three to six months, to evaluate how your sun exposure and/or supplement dose is working for you.

I believe we have a good chance of preventing a second wave of COVID-19, but to do that, we need people to take action to protect their health and strengthen their immune function. Please help us in this lifesaving effort by sharing my vitamin D report.

Again, the target populations are the elderly and people of color. It's now beyond evident that COVID-19 affects the elderly far more severely, on average, than younger individuals, and those living in nursing homes and assisted living facilities seem to be an extraordinarily increased risk of dying from COVID-19.

As you can see in the graphic below from June 2020, 42% of deaths occurred in nursing homes and assisted living facilities. Add to that the increased hospitalization rate and mortality among people of color, and it should be easy to see that targeting these two groups with common-sense strategies such as vitamin D optimization can, and most likely will, have a tremendous impact.

- Sources and References

https://articles.mercola.com/sites/articles/archive/2020/06/22/vitamin-d-deficiency-research-paper.aspx

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