WHO approves Oxford-AstraZeneca Covid-19 vaccine for emergency use

 The World Health Organization (WHO) on Monday listed AstraZeneca and Oxford University's COVID-19 vaccine for emergency use, widening access to the relatively inexpensive shot in the developing world.

16 February 2021

© Thomas Kienzle, AFP

A WHO statement said it had approved the vaccine as produced by AstraZeneca-SKBio (Republic of Korea) and the Serum Institute of India.

"We now have all the pieces in place for the rapid distribution of vaccines. But we still need to scale up production," said Tedros Adhanom Ghebreyesus, WHO Director-General.

The listing by the UN health agency comes days after a WHO panel provided interim recommendations on the vaccine, saying two doses with an interval of around 8 to 12 weeks must be given to all adults, and can be used in countries with the South African variant of the coronavirus as well.

The AstraZeneca/Oxford shot has been hailed because it is cheaper and easier to distribute than some rivals, including Pfizer/BioNTech's , which was listed for emergency use by the WHO late in December.

Nearly 109 million people have been reported to be infected by the novel coronavirus globally and more than 2.5 million have died, according to a Reuters tally.

Infections have been reported in more than 210 countries and territories since the first cases were identified in China in December 2019.

https://www.msn.com/en-gb/news/world/who-approves-oxford-astrazeneca-covid-19-vaccine-for-emergency-use/ar-BB1dHEWv

12 Feb 2021 BBC Covid-19 and Wuhan: Why don't we know more?

As countries scramble to protect themselves against Covid-19, the search for its origin continues.

12 February 2021

As countries scramble to protect themselves against Covid-19, the search for its origin continues.

Ros Atkins reports.

You can watch longer editions of "Ros Atkins on…" on BBC iPlayer.

Produced by: Courtney Bembridge, Henry Belot, Andrew Bryson and Clare Casey

https://www.bbc.com/news/av/world-56029070

BBC - Covid: Arthritis drug tocilizumab cuts deaths

 Arthritis drug tocilizumab cuts deaths from Covid

By Michelle Roberts
Health editor, BBC News online

12 February 2021

A drug normally used to treat arthritis can be a life-saver for some of the sickest hospital patients with Covid, new research shows.

For every 25 patients treated with tocilizumab, along with a cheap steroid already routinely given, an additional life would be saved, the experts say.

Some hospitals are now doing this.

As well as improving survival and recovery time, it can avoid patients needing to be moved to intensive care, say the NHS doctors.

Wendy Coleman, 62, received the treatment last year when she was admitted to Chesterfield Royal Hospital with severe Covid-19.

Wendy Coleman volunteered to take part in the trial

"I was struggling to breathe quite badly and on the verge of being placed in an intensive care unit.

"After I was given tocilizumab, my condition stabilised and I didn't get any worse. Up until then, it was quite scary as I didn't know if I was going to make it or not," she said.

• Dexamethasone 'first proven life-saving Covid drug'
• Two more life-saving Covid drugs discovered

Tremendous result

Researchers say around half of people admitted to hospital with Covid could benefit from the treatment.

They have carried out a clinical trial with more than 4,000 volunteers, like Wendy, and say the results are "tremendous".

Half of these Covid patients were given tocilizumab, via a drip, alongside usual care with a life-saving cheap steroid drug called dexamethasone.

In that group, compared to another group that did not receive the new drug:

• tocilizumab cut death risk - 596 (29%) of the patients in the tocilizumab group died within 28 days compared with 694 (33%) patients in the usual care group
• and it reduced the chance of a patient needing to go on a ventilator or dying from 38% to 33%

Combined, tocilizumab and dexamethasone should cut death risk by about a third for patients on oxygen and halve it for those on a ventilator, the researchers say.

Prof Martin Landray, joint chief investigator of the RECOVERY trial and a medical expert at Oxford University, said: "Used in combination, the impact is substantial. This is good news for patients and good news for the health services that care for them in the UK and around the world."

Dr Charlotte Summers, an intensive care medic at Addenbrooke's Hospital in Cambridge, said: "These findings are a tremendous step forwards. This therapy looks like it keeps people out of the intensive care unit so they never need to see people like me which can only be a good thing."

The treatment isn't cheap, costing around £500 per patient on top of the £5 course of dexamethasone. But the advantage of using it is clear - and less than the cost per day of an intensive care bed of around £2,000.

The drugs dampen down inflammation, which can go into overdrive in Covid patients and cause damage to the lungs and other organs.

The preliminary trial results will soon be submitted to a peer-reviewed medical journal.

Health and Social Care Secretary Matt Hancock said: "We are working quickly and closely with colleagues across the health system and sector to ensure every NHS patient who needs this treatment should be able to access it - reducing further pressures on the NHS and potentially saving thousands of lives."

NHS national medical director Prof Stephen Powis said it was another breakthrough in the fight against coronavirus.

https://www.bbc.com/news/health-56024772