Reality Check By Dave Whamond: Doc, It's the Only Way ...

Sugary drinks and meat are a fat-making combo, according to science

Sugar is almost unavoidable in food and drink today.  It makes up for 16 percent of our total energy intake and the largest source of it comes from sugary drinks.  Regardless of this, most of us probably enjoy a soft drink with a meal - but even if that meal is particularly healthy, all those benefits could be rendered obsolete by the beverage.

23 July 2017
Greg Evans in news 

A new study has found that drinking a sugar sweetened drink with a protein rich meal, affects our metabolism and builds up fat.

This limits the value of the protein which usually increases your satiety and your metabolism, but also decreases your intake of energy.

Steak and sugar

Research by BMC Nutrition wanted to see what happens to our bodily processes when we consume a sugar sweetened drink with a steak dinner.

To do this they asked volunteers to spend 24 hours in a metabolic chamber on two different occasions. 

By being in the controlled chamber, scientists could measure how the body utilises food nutrients, how many grams of fat, protein and carbohydrates are being used, and how many calories are being burned.

They then analysed how the participants used the nutrients, by examining their oxygen consumption, carbon dioxide production and urinary nitrogen excretion.

All volunteers then ate the same exact types of food throughout the 24 hours. 

This consisted of 15 percent protein during one day and 30 percent protein during the other day. Each meal was accompanied with a sugar-sweetened or artificially sweetened drink.

The results showed that drinking a sugary beverage with a meal decreased fat use, whilst having the same drink with a protein-rich meal decreased the fat use by 40 percent more.

They also discovered that of the calories absorbed from the drinks, only 80 of the 120 kcals were expended, which lead to a build up of 40 kcals regardless of level of protein in the meal.

Thus this shows the body's tendency to store fat from sugary drinks rather than burning it and adding more insight into the connection between these drinks and obesity.

So, next time your are out for steak dinner think twice about ordering that Coco-Cola.

https://www.indy100.com/article/sugar-drinks-protein-meat-food-fat-metabolism-health-science-study-biology-7855996?

Is EBC-46 (aka blushwood) as a cancer treatment a hoax?

It is not a hoax. It is being developed in Australia and has successfully treated both humans and pets. I do not know whether it will be a viable option for people outside of Australia ...

Amanda Kidari, studied at Norcross High School

Updated Apr 26 2017

It is not a hoax. It is being developed in Australia and has successfully treated both humans and pets. I do not know whether it will be a viable option for people outside of Australia as it would be years before it could make it state-side as it would have to go through strenuous testing in the States. My advice: if you get cancer or know someone that has it, try to get in contact with a doctor in Australia to get treatment for it. Medical tourism is a thing for a reason. Here is a link to article about it done by FORBES below.

Are Some of the Best Cancer Pharmaceuticals Hiding Out in The Rainforests?  (Copied below)

EDIT:

They are currently accepting patients for HUMAN CLINICAL trials. See the below link if you would like to know more about it. Cancer drugs take time to get onto the market and get accepted for treatment. Seek a medical professional for their advise/opinion but don’t forget to do your own research. Not a lot of people in the medical community in the US stay on top of research in other countries, so they may never have even heard of this new drug. Medical professionals in the US who want to shoot down this drug as a hoax, please do your own research before posting. You went to school to learn to become a medical professional. That learning doesn’t end when you get your PhD. If it did, then you would have killed a lot of people because things change every day as more research comes out and we adapt to the changes/discoveries. We thought blood letting cured people at one point. Please get our head out of your posterior.

QBiotics - EBC-46 & Humans

https://www.quora.com/Is-EBC-46-aka-blushwood-as-a-cancer-treatment-a-hoax

See also:   'Cancer-fighting' berry in Australian rainforests: EBC-46

JUN 1, 2015 @ 10:55 AM 
Are Some of the Best Cancer Pharmaceuticals Hiding Out in The Rainforests?

Steven Delco ,  

 CONTRIBUTOR

I make complex biotech investment ideas accessible to investors  

Opinions expressed by Forbes Contributors are their own.

Some years ago, at a scientific investors’ meeting in Belgium, I had the good fortune to meet an individual whom I would describe as an impressive business woman, scientist and drug hunter. She specialized in sleuthing new and unique compounds hidden in plants from one of the oldest and most diverse rainforests in the world.

It is no accident that Dr. Victoria Gordon, CEO of Qbiotics, Ltd.;Dr. Paul Reddell, cofounder of Ecobiotics, Ltd.; and chief scientist Dr. Peter Parsons are discovering important new compounds across a range of disease areas utilizing their uniquely-designed system of rainforest drug discovery.

Unlike many rainforest drug hunters who visit rainforests periodically, Dr. Gordon’s company is permanently situated in a facility near the rainforest in Yungaburra, Queensland, Australia. As a result of their proximity to the rainforest, Dr. Gordon and her team can frequently make observations and do experiments that lead to discovery.

At our initial meeting, Dr. Gordon’s investment presentation of Ecobiotics’ drug discovery technology was thought-provoking,but I was most impressed by the fruit of its application. In particular, a compound Dr. Gordon’s team found with anticancer properties impressed me. In the presentation, Dr. Gordon showed before-and-after photographs of several non-controlled experiments but with a clear effect; tumors in some cases as large as an orange in a number of animals species, after injected with the compound from a plant, appeared to melt away.

The compound, now named EBC-46, was discovered when a small marsupial in the forest was eating the fruit berry of a plant called Fontainea picrosperma. Afterwards, it became distressed and had to spit out the berry. This reaction was most likely due to a burning sensation experienced as a result of an inflammation caused by the berry of the Fontainea plant.

Fontainea Picrosperma
(blushwood)

These types of observations have led  Dr. Gordon’s team to isolate plants that exhibit characteristics of interest, such as described above, and take them into the laboratory for more extensive analysis for potential pharmaceutical applications. Arecent article about cancer drugs by The Scripps Institute, Why Natural Products? states that:

“Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades.  From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom.  From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom.  Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.”

As a result of years of investigation, Dr. Gordon’s team isolated a unique compound named EBC-46 from the berry spit out by the marsupial. It is patented as a new chemical entity, and the company has started clinical development. Today, the drug candidate EBC-46 has been spun out of the parent company Ecobiotics into a private drug development company called Qbiotics. EBC-46 is in clinical trials, phase II, for veterinary indications in dogs, and has started safety studies in humans. According to Dr. Gordon, once injected into the center of the tumor, EBC-46 shows a remarkable ability to elicit an immune response. As a result of the injection, the area swells and reddens as the tumor cells begin to die off, turning a purple color and than black like a big bruise. Within a month, the tumor is ablated and the tissue around the dead cells begins to heal like a wound.

A dog called Oscar pre-treatment with the berry compound (L) and 15 days after treatment

Dr. Parsons believes that this tumor ablation is due to hemorrhagic necrosis of the tumor, as the compound EBC-46 destroys the more fragile capillaries that feed the tumor. In other words, the tumor cells are starved of blood supply. The immune response that follows helps clean out the necropsied tissue and initiates a healing process.

Although much of the clinical results for EBC-46 up to  date has been anecdotal these results look very promising. If the ongoing clinical trials come close to the uncontrolled data results EBC-46 could become a very important tool in our arsenal of treatments against cancer. Another natural product of note is a topical drug called "Picato" marketed by Leo Pharma with a very good safety and efficacy record for the treatment of actinic kerotosis a precancerous condition of the skin. Picato or Ingenol mebutate seems of have a very similar mechanism of action to EBC-46 and in my opinion serves as a good proof of concept for EBC-46. Qbiotics has applied its drug candidate EBC-46 in a more aggressive way by injecting it into solid tumors where Leo Pharma markets a topical application of Picato. Ingenol mebutate is also a natural product derived from a plant called Euphorbia Peplus.

While the science and mechanism of this immune response it not fully understood Dr. Parsons and Dr. Boyle have published in Plos One, October 2014 | Volume 9 | Issue 10 | e108887 a study entitled “Intra-Lesional Injection of the Novel PKC Activator EBC- 46 Rapidly Ablates Tumors in Mouse Models”.In this study, they found that EBC-46 in mice most likely worked through the modulation of the Protein Kinase C complex. As stated in their publication, their results demonstrated that “a single intra-lesional injection of EBC-46 causes PKC-dependent hemorrhagic necrosis, rapid tumor cell death and ultimate cure of solid tumors in pre-clinical models of cancer.”

EBC-46 Structure

In conversations with Dr. Gordon, I learned that many millions of years of evolution has produced a complex diversity of plant compounds that instruct and regulate the multifaceted interaction of plants and animals in the rainforest, mimicking an organism. The type of complex structures designed by nature to achieve the above over millions of years would probably take an infinitely large number of organic scientists years to reproduce in the laboratory. Has nature produced these compounds just waiting in the rainforests for us to discover them?

* In 2009-2010 I was a consultant to Ecobiotics, Ltd and Qbiotics, Ltd. Currently I have no financial relationship or ownership in either company.

https://www.forbes.com/sites/stevendelco/2015/06/01/are-some-of-the-best-cancer-pharmaceuticals-hiding-out-in-the-rainforests/#a6e440410fc0


See also:   'Cancer-fighting' berry in Australian rainforests: EBC-46

Coconut Oil – Are You Coco-Nuts to Eat It?

Did you know that 50 percent of media headlines about medical studies are dead wrong? And that many of these headlines don’t accurately match the conclusions of the studies they cover?

Written byMARK HYMAN, MD

That’s from a review published in the New England Journal of Medicine.

It makes me sad and furious at the same time that journalists don’t do their homework and create firestorms of confusion because of their negligent work.

That is exactly what happened when USA Today published their article, “Coconut Oil Isn’t Healthy. It’s Never Been Healthy.” Shame on you USA Today editors for doing such a sloppy job of journalism.

Why the American Heart Association Has Been and Still Is Wrong

First, there is not a single study showing that coconut oil causes heart disease. Not one. Second, the whole case against coconut oil is founded on a hypothesis that has been proven wrong. It’s the diet-heart hypothesis. Saturated fat raises LDL cholesterol. LDL cholesterol causes heart disease. Anything that raises LDL cholesterol is bad. Only problem is that the data does not support this hypothesis.

If you are geeky and want to read more where I cover the science in detail, read my blog “Fat: What I Got Wrong, What I Got Right.” But just like it took 150 years after Copernicus recognized that the earth revolves around the sun before it was finally accepted, it will take a while for the world to catch up with the false idea that low-fat and low-cholesterol diets won’t save us from heart disease. In fact, low-fat diets cause heart disease. I have covered all this in my last book, Eat Fat, Get Thin with hundreds of references.

The USA Today article was based on a review by the American Heart Association (AHA). They published a review of fat and heart disease. The AHA has been at the vanguard of bad advice for decades since they first hooked onto the “fat is bad and will kill you” meme. They told us to eat very low fat, low cholesterol diets and to eat tons of starchy carbs. By the way, the AHA gets huge funding from cereal makers that put the AHA seal of approval on sugary (including cereal makers) cereals because they are “fat free” despite containing 75 percent sugar. Except now the overwhelming amount of research has proved that idea to be dead wrong. In fact, their recommendations have killed millions of people (no joke) from heart disease and diabetes. That’s why the very conservative 2015 USDA Dietary Guidelines removed any upper limits on dietary fat and eliminated any restrictions on dietary cholesterol. In fact, after decades of telling us to avoid eggs and shrimp they said, “Cholesterol is not a nutrient of concern for overconsumption.”

If you are interested in the corruption of the AHA, its funding is supported by the Pharma industry, industrial food giants (including sugary cereal makers) and industrial vegetable oil manufacturers, then read this recent blog on Medium entitled, Is the American Heart Association a terrorist organization? I’m not calling the AHA a terrorist organization, I just want you to read the article and question who’s really pulling the strings.

How could this happen you might wonder? How could the scientists have gotten it so wrong? It all comes down to how we do the research. Most nutrition research is based on what we call observational studies. You follow a group of people for a long time, you ask them once a year what they ate last week and you see if patterns emerged. Good luck if they can remember. And people aren’t always honest – if they think butter is bad, then they will underreport consumption. Problem is those types of studies do not prove cause and effect, just correlation. If I did a study on women over 55-years of age who have sex, I could conclude that sex RARELY leads to pregnancy. Pretty meaningless. The populations studied that ate saturated fats also were coincidentally smokers, didn’t exercise and ate otherwise unhealthy diets. Those who actually ate well, exercised and didn’t smoke (i.e. lead healthier lifestyles) also didn’t eat saturated fats because they were told not to. Studies prove that it was the well-rounded healthy habits that saved them, not less saturated fats.

Why Saturated Fats Are Not Bad and Are Essential for Health

This is exactly why multiple recent studies have shown no link between saturated fat and heart disease. You can read most of the important ones from the references, below, in my book and in the Fat: What I Got Wrong, What I Got Right article. In fact, there have been very few cause and effect studies in nutrition – they are hard to do, take a long time and cost a lot. But two of the largest ones every published show that fat and saturated fat are not the problem. The first was the PREDIMED studywhere researchers gave 7,000 participants olive oil (which contains 20% saturated fat) or nuts vs. a low-fat diet. PERDIMED had to stop the study because the people who were following the low-fat diet were dying. 

The next study was completed over 40 years ago, but it wasn’t published because the results contradicted the prevailing dogma that saturated fat was bad and that LDL cholesterol caused heart disease. This was a study that could not be conducted today because it would be considered unethical. They fed 9,000 people in mental hospitals butter and saturated fats or corn oil (polyunsaturated vegetable oil, which the AHA report says we should eat more of). And, guess what? Those who ate the corn oil had more heart attacks and deaths, despite lowering their LDL cholesterol. Really? Yes, it’s true. In fact, for every 30-point drop in LDL the risk of heart attack went up 22 percent. To top it off a recent review of all the science on big bad butter looking at 6.5 million patient years of butter eating, researchers found that butter eaters had no increased risk of heart disease, but they did have decreased risk of type 2 diabetes. You read that right. Butter = lower risk of type 2 diabetes. And if you still need to be convinced, here’s a review of 17 meta-analyses(reviews of all the best and relevant research) showing no link between saturated fat and heart disease.

The whole idea that LDL cholesterol causes heart disease is the reason we have a multi-billion dollar statin industry. One study of over 130,000people who had heart attacks over 5 years showed that 75 percent had normal LDL and 50 percent had optimal LDL cholesterol. But only 10 percent had normal HDL or the protective cholesterol. Guess what raises HDL? Saturated fat. And coconut oil raises it the most of any saturated fat. And what lowers it? A low-fat, high-starch, and high-sugar diet. We need cholesterol and saturated fat for the health of every cell membrane, for your brain cells, your sex hormones and more. Cholesterol is not the cause of heart disease, it is the band-aid that tries to repair the arteries when damage occurs from a low-fat, high-starch, high sugar diet. This causes pre-diabetes and inflammation from a processed food diet, environmental toxins, a bad gut from a low fiber, processed diet or anything that causes inflammation.

Before we get off saturated fats, here’s one BIG warning. They ARE a problem if you eat them in the context of a high-sugar, high-starch, processed foods diet. It’s what I call sweet fat. Stay away. No bagels and butter. No donuts or French fries. Stick with butter and broccoli.

Why We Shouldn’t Be Mainlining Omega-6 Vegetable Oils

The other recommendation from the AHA other than dramatically lower saturated fat intake is to increase omega-6 refined vegetable oils. Bad idea. Yes, some studies show a lower risk of heart disease with a higher intake of omega-6 oils (otherwise known as polyunsaturated fats or PUFAs which include soy, corn, safflower, canola oils). Again I cover this in detail in Eat Fat, Get Thin, but the take-home is this: If you eat saturated fat in the context of the typical American diet, it will cause problems and the people in omega-6 studies were eating exactly that. And to make it more confusing, the studies looking at PUFAs included both omega-3 (super protective) and omega-6 fats. The omega-3s made the omega-6 cousins look better. When you look at just the studies of the effects of omega-6 fats, you find actually increase the risk of heart attacks. And it is just common sense and evolutionary sense – our intake of these refined, heat processed, hexane treated, chemically deodorized oils (never consumed before in human history) have increase more than 1000 times (that’s 100,000 percent) in the last 100 years. Saturated fats make your cholesterol molecules stable and less likely to oxidize or go rancid. It is oxidized cholesterol that causes heart attacks. The PUFA’s are unstable and easily oxidized so when they are incorporated into cholesterol they make it unstable and go rancid – which is bad for your heart.

Is Coconut Oil Healthy?

We have had a coconut craze. What’s the deal? Broccoli is healthy but if that’s all you ate you would get sick. Coconut oil is healthy but only as part of an overall healthy diet not as the main course. Coconut oil has been consumed by populations in the South Pacific for thousands of years without ill effect. It has so many health benefits. You can read more in my article Is Coconut Oil Bad for My Cholesterol. But here’s the short list of benefits. It raises HDL, the good cholesterol. It improves the quality and size and type of cholesterol. It lowers the total cholesterol to HDL ratio – a far better predictor of heart disease than LDL. And cultures with 60 percent of their diet as coconut oil have no heart disease. It also contains a unique type of saturated fat called MCT oil that boosts metabolism, reverses insulin resistance, and improves cognitive function. Coconut oil is also anti-fungal and anti-microbial and it contains lauric acid that is great for immune function. The only other good source of lauric acid is breast milk, which contains 24 percent saturated fat – far higher than the 6 percent the AHA recommends.

Who would you trust, nature/God or the American Heart Association? So, I am sorry you have to be buffeted about by bad conclusions from insufficient outdated science and bad journalism. But hopefully reading this helps, and if you are so inclined check out the references below, my other blogs on this topic, and my book so you can come to your own conclusions. 

Wishing you health and happiness,

Mark Hyman, MD

References

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http://drhyman.com/blog/2017/06/26/coconut-oil/?