May 04, 2015
Story at-a-glance
- Curcumin, a bioactive ingredient in turmeric, exhibits over 150 potentially therapeutic activities, including anti-inflammatory and antimicrobial activity, and anti-cancer properties that have been intensely studied
- Its benefits are related to its ability to modulate 700 genes; positively modulate more than 160 different physiological pathways; make your cells’ membranes more orderly; and affect signaling molecules
- Curcumin can help you maintain a healthy digestive system, and may be useful against Helicobacter pylori (H.pylori) infections, such as gastritis, peptic ulcer, and gastric cancer
By Dr. Mercola
Turmeric is a yellow-pigmented curry spice that is often used in Indian cuisine. But this spice is far more than a cooking staple. It also has a long history of medicinal use in traditional Chinese medicine (TCM) as well as Ayurvedic medicine.Traditional medicinal uses include the treatment of liver disease, skin problems, respiratory and gastrointestinal ailments, sprained muscles, joint pains, and general wound healing.Its benefits have since been well documented in the medical literature, and curcumin—one of the most well-studied1,2 bioactive ingredients in turmeric— has been found to promote health and protect against a wide array of health conditions.It actually exhibits over 150 potentially therapeutic activities, including anti-inflammatory and antimicrobial activity, as well as potent anti-cancer properties that have been intensely studied.
What Makes Curcumin Such Potent Medicine?
Researchers have found a number of different mechanisms of action for curcumin, and part of the answer as to why curcumin appears to be such potent medicine is because it can:
- Modulate about 700 of your genes
- Positively modulate more than 160 different physiological pathways3
- Make your cells’ membranes more orderly4
- Affect signaling molecules.5 For example, curcumin has been shown to directly interact with:
Inflammatory molecules Cell survival proteins Histone Human immunodeficiency virus type 1 (HIV1) integrase and protease DNA and RNA Various carrier proteins and metal ions As a result of these (and potentially other) effects, curcumin has the ability to benefit your health in a variety of ways, and prevent a number of different diseases. According to a study published in the Natural Product Reports6 in 2011, curcumin can be therapeutic for:
Lung and liver diseases Neurological diseases Metabolic diseases Autoimmune disorders Cardiovascular diseases Inflammatory diseases7 More specifically, studies8,9 that now number in the hundreds have shown that curcumin and other bioactive compounds in turmeric can:
Support healthycholesterol levels Prevent low-density lipoprotein oxidation Inhibit platelet aggregation Suppress thrombosis and myocardial infarction Suppress symptoms associated with type 2 diabetes Suppress symptoms of rheumatoid arthritis Suppress symptoms of multiple sclerosis Protect against radiation-induced damage and heavy metal toxicity Inhibit HIV replication Reduce systemic inflammation in obese individuals10 Enhance wound healing Protect against liver damage11 Increase bile secretion Protect against cataracts Protect against pulmonary toxicity and fibrosis
Turmeric May Help Combat Alzheimer’s Disease and Other Inflammatory Conditions
Curcumin is capable of crossing your blood-brain barrier, which is one factor that has led researchers to investigate its potential as a neuroprotective agent for neurological disorders such as Parkinson's and Alzheimer’s disease.12,13The potent antioxidant and anti-inflammatory properties of curcumin suggests it may also promote brain health in general. In the case of Alzheimer’s, recent animal research14 has discovered another bioactive ingredient in turmeric, besides curcumin, that adds to its neuroprotective effects.This compound, called aromatic turmerone, help endogenous neutral stem cells (NSC) to grow, and these stem cells play an important role brain repair and regeneration activities. According to lead author Adele Rueger:15"While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal."Curcumin may also be helpful. Previous research has shown that curcumin helps inhibit the accumulation of destructive beta-amyloids in the brain of Alzheimer's patients, as well as break up existing plaques associated with the disease. People with Alzheimer's tend to have higher levels of inflammation in their brains, and curcumin is perhaps best known for its potent anti-inflammatory properties. It can inhibit both the activity and the inflammatory metabolic byproducts of cyclooxygenase-2 (COX2) and 5-lipooxygenase (5-LOX) enzymes, as well as other enzymes and hormones that modulate inflammation.Another common condition that can benefit from curcumin’s anti-inflammatory activity is osteoarthritis. Research16 published in 2011 found that patients who added 200 mg of curcumin a day to their treatment plan had reduced pain and increased mobility compared to the control group. Earlier research17 also found that a turmeric extract blocked inflammatory pathways, effectively preventing the launch of a protein that triggers swelling and pain.
Curcumin Appears to Be Universally Useful for All Cancers
Among the most exciting benefits of turmeric is its potent anti-cancer activity.18,19 Curcumin actually has the most evidence-based literature20 supporting its use against cancer of any other nutrient, including vitamin D! As noted by Dr. William LaValley—one of the leading natural medicine cancer physicians whom I’ve previously interviewed on this topic—curcumin is unique in that it appears to be universally useful for just about every type of cancer. This is odd, considering the fact that cancer consists of a wide variety of different molecular pathologies. One reason for this universal anti-cancer proclivity is curcumin’s ability to affect multiple molecular targets, via multiple pathways.Once it gets into a cell, it affects more than 100 different molecular pathways. And, as explained by Dr. LaValley, whether the curcumin molecule causes an increase in activity of a particular molecular target, or decrease/inhibition of activity, studies repeatedly show that the end result is a potent anti-cancer activity. Moreover, curcumin is non-toxic, and does not adversely affect healthy cells, suggesting it selectively targets cancer cells—all of which are clear benefits in cancer treatment. Research has even shown that it works synergistically with certain chemotherapy drugs, enhancing the elimination of cancer cells.
Curcumin Also Has Potent Antimicrobial Activity
Curcumin can also help you maintain a healthy digestive system, and may be useful against health issues caused by the bacterium Helicobacter pylori (H.pylori), such as gastritis, peptic ulcer, and gastric cancer. H. pylori is thought to affect more than half of the world's population, and has been identified as a Group 1 carcinogen by the World Health Organization.21Traditionally, H. pylori infections are treated with antibiotics, but with rising drug resistance, such treatments are becoming increasingly threatened.The good news is, curcumin may be a viable alternative. According to a 2009 study,22 curcumin has been shown to effectively stop the growth of H. pylori in vitro, regardless of the genetic makeup of the strains. In mice, curcumin “showed immense therapeutic potential against H. pylori infection as it was highly effective in eradication of H. pylori from infected mice as well as in restoration of H. pylori-induced gastric damage,” the researchers noted.
Suggestions for Using Curcumin Therapeutically
While turmeric is readily available in the spice section of any grocery store, it’s important to realize that if you’re looking for clinical results, it’s not enough to simply use turmeric in your cooking. The turmeric root itself contains only about three percent curcumin concentration, and curcumin is poorly absorbed by your body to boot. When taken in its raw form, you’re only absorbing about one percent of the available curcumin. Even in supplement form it’s unlikely to provide the results shown in various disease studies. If you want to use curcumin therapeutically, you can try one of the following three alternatives:
- Locate a high quality turmeric extract that contains 100 percent certified organic ingredients, with at least 95 percent curcuminoids. The formula should be free of fillers, additives, and excipients (a substance added to the supplement as a processing or stability aid), and the manufacturer should use safe production practices at all stages: planting, cultivation, selective harvesting, and then producing and packaging the final product. Typical anticancer doses are up to three grams of good bioavailable curcumin extract, three to four times daily.
- Make a microemulsion using raw curcumin powder. Combine one tablespoon of the powder with 1-2 egg yolks and a teaspoon or two of melted coconut oil. Use a high speed hand blender to emulsify it. Keep in mind that curcumin is a very potent yellow pigment that can permanently discolor surfaces, so take precautions to avoid "yellow kitchen syndrome.”
- Boil the curcumin powder. Another strategy that can help increase absorption is to put one tablespoon of the curcumin powder into a quart of boiling water. It must be boiling when you add the powder as it will not work as well if you first put it in room temperature water and then heat the water and curcumin. After boiling it for 10 minutes you will have created a 12 percent solution that you can drink once cooled. It will have a woody taste. The curcumin will gradually fall out of solution however. In about six hours it will be down to a six percent solution, so it's best to drink the water within four hours.
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