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Wednesday, 30 September 2020

WHO wants 120m rapid virus tests for poorer states

 30 Sep 2020

GENEVA: Some 120 million rapid tests for Covid-19 will be made available to poorer countries at US$5 (RM20.80) each, the World Health Organisation announced – if it can find the money.

  • The Star Malaysia
  • AFP

The WHO said the US$600mil (RM2.5bil) scheme would enable low- and middle-income countries to close the dramatic gap in testing for the new coronavirus, which has now killed more than a million people since first being recorded in China in December.


The quick tests, to be distributed across 133 countries over the next six months, are not as reliable as the PCR nasal swab tests but are far faster, cheaper and easier to carry out.


“We have an agreement, we have seed funding and now we need the full amount of funds to buy these tests,” WHO director-general Tedros Adhanom Ghebreyesus told a virtual press conference.


Last week, the WHO issued the first emergency-use listing for a quality, antigen-based rapid diagnostic test (RDT), with others expected to follow.


“A substantial proportion of these rapid tests – 120 million – will be made available to low- and middle-income countries,” said Tedros.


“These tests provide reliable results in approximately 15 to 30 minutes, rather than hours or days, at a lower price, with less sophisticated equipment.


“This will enable the expansion of testing, particularly in hard-to-reach areas that do not have lab facilities or enough trained health workers to carry out PCR tests.”


Global Fund executive director Peter Sands said the RDTs were no silver bullet but were a hugely valuable complement to PCR tests. —


- AFP - 

Friday, 25 September 2020

Airlines look to Covid tests that give results in minutes

 European airlines are pinning hopes on pre-flight COVID-19 tests that deliver results as fast as pregnancy tests to help restore passengers’ confidence in taking to the skies in confined spaces with shared air.

SEPTEMBER 23, 2020

By 


















Germany’s Lufthansa, at the mercy of government bailouts for survival, is in talks with Swiss drugmaker Roche over deploying so-called antigen tests, according to two people familiar with the discussions, as the airline aims to make them available next month.

Italian operator Alitalia, meanwhile, told Reuters that from Wednesday it would add two flights from Milan to Rome, to the two it is already offering from Rome to Milan, exclusively for passengers with negative tests.

The tests are administered by health authorities at the airports and included in ticket prices. If they prove popular and safe, these antigen-tested flights will be expanded to more domestic, and later international, routes, the airline said.

Unlike laboratory-based molecular tests that have been the staple of health authorities in the pandemic, antigen tests do not require machines to process. Much like pregnancy tests, they can produce results in about 15 minutes.

However the tests require an uncomfortable nasal swab and are not as accurate as the molecular, or PCR, tests. They generally produce more “false negatives” which could mean sick people could slip through the cracks and onto planes.

An increasing number are hitting the market, from companies such as Abbott Laboratories, Becton Dickinson & Co and Quidel Corp and Roche, which is rebranding antigen tests from South Korea’s privately held SD Biosensor.

Airlines are pressing governments to embrace alternatives to blanket travel restrictions amid a resurgence of COVID-19 cases in Europe.

Rapid antigen tests that can be administered by non-medical staff are expected to become available in coming weeks for as little as $7 each, the head of industry body the International Air Transport Association said on Tuesday.

NEGATIVE-ONLY FLIGHTS

Despite the drawbacks of such antigen tests, carriers hope they could tip the balance in convincing people to fly.

“It is to give ... confidence, at a specific point in time, that the result is positive or negative,” said Christian Paulus, a Roche research and development manager.

“The PCR remains the gold standard. Therefore if there are any questions open, or if the clinical appearance of the person who had a negative test, if the person has symptoms like a fever, then you would for sure do confirmatory testing.”

Alitalia launched its “COVID Tested Flights” programme from Rome to Milan last week, and will expand it from Wednesday. Only passengers with negative COVID-19 results can board.

“So far no positive passengers have been found,” said an Alitalia spokesman, adding that many chose to take the airline’s antigen tests the night before the flight. Travellers can access airport-testing facilities via a preferred lane with their tickets.

The airline plans to analyse findings around the middle of October, but already expects antigen-tested flights will be expanded to domestic and later international routes. “First, we have to see how this experiment goes,” the spokesman said.

The pre-flight antigen tests follow a scheme in Italy where such tests were used defensively.

SD Biosensor said its tests had been deployed at Italian airports for incoming tourists, to avoid a renewed COVID-19 wave imported from infection hotspots.

‘BETTER THAN QUARANTINE’

Lufthansa Chief Executive Carsten Spohr last week told employees during a townhall meeting that the airline was in talks with Roche. The drugmaker started selling the rapid tests this week, and said SD Biosensor could initially supply it with about 40 million tests per month.

The Lufthansa tests could initially go to cabin crews, a spokeswoman said, though Bjoern Becker, a senior director of product management, ground & digital services for the Lufthansa Group, said the tests could also be made available to first-class and business-class passengers.

“We think the tests would be a better option than putting somebody into quarantine,” the airline spokeswoman said.

Beyond airlines, Germany is eyeing broader antigen test use from October, including in nursing homes where older patients have been hardest hit by the deadly virus.

Regulators still worry about test accuracy, which typically detect the virus 80% to 90% of the time, below the 95% rate of lab tests.

Still, some officials don’t want the perfect to be the enemy of the pretty good as they pursue some semblance of economic normality.

“They’re good enough,” German health minister Jens Spahn said, pledging antigen tests in “significant quantities”. The state of Bavaria has already ordered 10 million.

Reporting by John Miller in Zurich, Andreas Rinke in Berlin, Ludwig Burger, Patricia Weiss and Ilona Wissenbach in Frankfurt and Emilio Parodi in Milan; Editing by Pravin Char

https://www.reuters.com/article/uk-health-coronavirus-airlines-testing-f/positive-about-flying-airlines-look-to-covid-tests-that-give-results-in-minutes-idUKKCN26E0TD


ALSO:


Airlines call for COVID-19 tests before all international flights


Tuesday, 22 Sep 2020 9:47 PM MYT

PARIS (Reuters) - Global airlines on Tuesday called for pre-departure COVID-19 testing for all international passengers to replace the quarantines they blame for exacerbating the travel slump.

Rapid and affordable antigen tests that can be administered by non-medical staff are expected to become available in "coming weeks" and should be rolled out under globally agreed standards, the head of the International Air Transport Association (IATA) said during an online media briefing.

"We don’t see any alternative solution that would be less challenging or more effective," IATA Director General Alexandre de Juniac said.

Airlines hammered by the pandemic are pressing governments to embrace alternatives to blanket travel restrictions that are still hampering a traffic recovery - and now tightening again in Europe amid resurgent case numbers.

With rapid antigen tests becoming available for as little as $7 each, De Juniac said, airlines will push for their use to be endorsed by International Civil Aviation Organisation (ICAO), the U.N. agency that oversees global aviation rules.

A global agreement is needed to ensure test results on departure are accepted on arrival, he added. "It will also boost passenger confidence that everybody on the aircraft has been tested."

Antigen tests are faster but generally more likely to miss positive cases of the virus than laboratory-based molecular diagnostic tests.

Among companies marketing the new tests, German diagnostics specialist Qiagen said earlier this month it planned to launch a COVID-19 antigen test that provided results in 15 minutes and could be deployed in airports or stadiums.

(Reporting by Laurence Frost; editing by Jason Neely and Mark Potter)

https://www.thestar.com.my/news/world/2020/09/22/airlines-call-for-covid-19-tests-before-all-international-flights

Wednesday, 16 September 2020

Factbox: The race for a coronavirus vaccine - Reuters

(Reuters) - More than 150 potential vaccines are being developed and tested globally to stop the COVID-19 pandemic, with 35 in human trials, according to the World Health Organization (WHO).

SEPTEMBER 16, 2020


The United Arab Emirates this week granted emergency approval for use of a coronavirus vaccine developed by Chinese state-owned pharmaceutical company Sinopham, six weeks after human trials in the Gulf Arab state started.
The following list tracks the latest developments from major drugmakers and research institutes that have started human trials for their vaccine candidates:
For a separate FACTBOX on treatments under development, click
Company State of play Development phase  
Not applicable Russia completes volunteer recruitment for Vaccine produced antibody response in all late-stage trials of Sputnik V vaccine, developed participants in early-stage trials by Moscow’s Gamaleya Research Institute
AstraZeneca Some trials of the British drugmaker’s vaccine have Late-stage trials resumed after being voluntarily paused globally due to an unexplained illness in a study participant
Sinopharm Developing two vaccines, one of which has shown United Arab Emirates grants emergency promise in humans approval; late-stage trials in Bahrain ongoing
Pfizer and BioNTech SE Vaccine produced virus-neutralizing antibodies in Expects late-stage data in October, plans to early-stage trials submit for approval immediately
Moderna Inc On track to deliver up to 1 billion doses a year, 30,000-subject final stage trial began on beginning 2021 July 27
Sinovac Biotech CoronaVac approved for emergency use in China to Launched final-stage trial in Indonesia vaccinate high-risk groups such as medical staff
CanSino Biologics Early results showed vaccine is safe Late-stage trials have begun in Russia
Inovio Pharma Vaccine candidate induced immune responses in Mid-stage trials planned for this month healthy volunteers in early-stage study
Chongqing Zhifei Biological Unit Anhui Zhifei Longcom Biopharmaceutical has Mid-stage trial Products begun human trials
Bharat Biotech Vaccine approved for human trials in India Early- to mid-stage trials
Johnson & Johnson Vaccine prevented hamsters from getting severely ill in pre-clinical study 
To begin mid-stage trials in Spain, the Netherlands and Germany, and late-stage study planned for this month
Novavax Early stage results show participants developed Mid-stage testing antibodies after two doses
GlaxoSmithKline Partnered with Sanofi to develop a vaccine Early-mid stage trials to begin in September
CureVac German biotech expects data in September/October Mid-stage trial
Clover Biopharmaceuticals Chinese developer received $66 mln from an epidemic Early-stage trials
response group
Not applicable Scientists at Imperial College London running Early-stage trials
trials
Genexine South Korean company has begun human trials Early-stage trials
Not applicable Institute of Medical Biology at Chinese Academy of Mid-stage trials
Medical Sciences testing a vaccine
Walvax Biotechnology Trials sponsored by Walvax and a Chinese military Mexico to conduct late-stage trials
research institute, have begun
Medicago Studying a plant-based vaccine Early-stage trials
Cadila Healthcare Plans to finish late-stage trials by early 2021 Early-stage trials
Not applicable University of Queensland began human trials with Early-stage testing (bit.ly/2Eo5iDg)
Australia’s CSL.
Arcturus Therapeutics and Dosed first group of participants in early-stage Early-stage testing
Duke-NUS trials
Osaka University, AnGes, A single-center trial in 30 healthy volunteers Early-stage testing (bit.ly/3gaEiFB)
Takara Bio
Kentucky Bioprocessing British American Tobacco unit expects to begin trial in 180 adults Early-stage testing planned (bit.ly/2BJDU1M)
Vaxine Pty/Medytox Expects to start mid-stage trials Early-stage testing
Medigen Vaccine Biologics Begins early-stage study in 45 people Early-stage trial (bit.ly/2XbnAOS)
Corp/NIAID/Dynavax
Merck & Co Expects to begin human trials later this year Early-stage trial planned
ReiThera/Leukocare/Univerce Collaborating on a potential shot Early-stage trial (bit.ly/2YgDJmo)
lls
Not applicable Cuba's Instituto Finlay de Vacunas begins Early-stage trial (bit.ly/3gsMu35early-stage trials in 676 participants
Themis BIO/Institute Merck's unit started early-stage study in 90 people Early-stage trial (bit.ly/3lhUhVa)
Pasteur/University of in collaboration with Institute Pasteur
Pittsburg CVR
Not applicable Rospotrebnadzor, a Russian federal agency, begins Early-stage trials (bit.ly/2YzhwjHstudying potential vaccine
Research Institute for Studying QazCovid-in in healthy volunteers aged Early-mid stage trials (bit.ly/3jOYIFc)
Biological Safety 18-50
Problems, Rep of Kazakhstan
West China Hospital, Studying safety, tolerability and immunogenicity of Early-stage trials (bit.ly/3jK7CUE)
Sichuan University vaccine candidate in healthy Chinese adults
Reporting by Vishwadha Chander and Manas Mishra in Bengaluru; Editing by Shounak Dasgupta and Sriraj Kalluvila

https://af.reuters.com/article/idUSKBN266259




Stocks mentioned in the article
ChangeLast1st jan.
ANGES, INC. 0.07%1490End-of-day quote.133.18%
ARCTURUS THERAPEUTICS HOLDINGS INC. 2.01%42.06Delayed Quote.286.94%
ASTRAZENECA PLC 0.50%8646Delayed Quote.13.12%
BIONTECH SE -0.83%66.92Delayed Quote.97.52%
BRITISH AMERICAN TOBACCO PLC -0.30%2696Delayed Quote.-16.32%
CADILA HEALTHCARE LIMITED 3.56%388.4Delayed Quote.47.48%
CANSINO BIOLOGICS INC. 1.07%179.4End-of-day quote.204.33%
CHONGQING ZHIFEI BIOLOGICAL PRODUCTS CO.,LTD. 2.34%127.73End-of-day quote.157.21%
GENEXINE INC End-of-day quote.
GLAXOSMITHKLINE PLC 0.34%1530Delayed Quote.-14.29%
INOVIO PHARMACEUTICALS, INC. 20.41%13.63Delayed Quote.313.03%
LONZA GROUP 0.54%560.2Delayed Quote.57.81%
MEDIGEN VACCINE BIOLOGICS CORPORATION 2.06%99End-of-day quote.247.37%
MODERNA, INC. 5.04%66.88Delayed Quote.241.92%
NOVAVAX, INC. 4.29%110.34Delayed Quote.2,672.36%
PFIZER LIMITED 0.71%4944.5End-of-day quote.17.05%
PFIZER, INC. -0.14%36.96Delayed Quote.-5.54%
SANOFI -0.23%88.54Real-time Quote.-0.98%
SINOPHARM GROUP CO., LTD. 0.43%18.7End-of-day quote.-34.27%
SINOVAC BIOTECH LTD. -0.31%6.47Delayed Quote.-6.77%
TAKARA & COMPANY LTD. -0.61%2299End-of-day quote.32.74%
TAKARA BIO INC. -0.88%2823End-of-day quote.37.24%
TAKARA HOLDINGS INC. 0.18%1101End-of-day quote.9.55%
US DOLLAR / RUSSIAN ROUBLE (USD/RUB) -0.24%74.75571Delayed Quote.21.49%
WALVAX BIOTECHNOLOGY CO., LTD. 3.89%55.54End-of-day quote.71.21%
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