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Showing posts with label Liver Re-Generation. Show all posts
Showing posts with label Liver Re-Generation. Show all posts

Tuesday, 15 October 2019

Foods that help liver regeneration

Did you know there are foods that can help promote liver regeneration? Did you also know the liver is the only organ in the body which can regenerate? It’s true. You may have heard that a starfish can grow back a missing limb, and lizards can grow back their tails; similarly, if a part of the liver is damaged it can partake in liver regeneration.

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Type 2 diabetes exenatide treatment can benefit NAFLD patients due to glucose control in liver: Study
In a study published in The Journal of Biological Chemistry researchers uncovered that liver regeneration functions much simpler than once believed. In the past it was shown that cells which are part of regeneration act as they would if they were in an embryo. In the fairly recent study scientists uncovered specific proteins that induce regeneration. They felt that by being able to stimulate such proteins they would be able to better help those with severe liver damage or those who have had portions of their liver removed.
After extensive testing, the scientists uncovered that previous theories of cells acting as they would in embryos was actually not true, but rather liver regeneration occurs due to an increase in cells which multiply through regular cell division. Therefore, researchers believe stimulating liver regeneration is possible by activating identified proteins.

Foods useful for liver regeneration process

Foods useful for liver regeneration processAlthough the liver is able to regenerate itself, it’s important you keep it healthy and eat foods which can further help promote liver regeneration. The following foods can help boost liver health as well as function.
Garlic: Garlic has been shown to help reduce bad cholesterol which is associated with poor liver health; eating garlic regularly can help promote good liver health. Enzymes in garlic also help the liver remove toxins, contributing to a healthier body overall.
Grapefruit: Grapefruit is packed with powerful antioxidants and fiber. Grapefruit can contribute to good cholesterol and boost the liver-cleansing process. One word of caution is that grapefruit can negatively interact with medications, so speak to a doctor before incorporating grapefruit into your diet.
Leafy green vegetables: Spinach, broccoli and kale are just some examples of leafy green vegetables. Leafy green vegetables all work to assist your liver in the cleansing process and help improve its function. Furthermore, they provide the body with chlorophyll which protects the body from toxins.
Avocados: Avocados pack nearly 20 essential nutrients and vitamins; not only are they good for your body, but they feed your liver all the right stuff. Avocados can help neutralize free radicals as well as promote the production of glutathione which helps with toxin removal.
Apples: We know apples are good for overall health; you should continue with your apple-a-day trend as they can help promote liver cleansing and remove toxins in the digestive tract.
Brussels sprouts: Brussels sprouts are similar to garlic because they also contain sulfur, so that alone is enough to promote a healthier liver. Furthermore, Brussels sprouts contain antioxidants which fight free radical damage. For maximum benefits cook Brussels sprouts with garlic for an optimal liver-cleaning meal.

Other foods for liver regeneration

Aside from the above mentioned foods, there are others which can keep the liver healthy, promote liver cleansing and ensure you stay the healthiest you can be. The next time you opt for a meal or a snack make sure you also add these foods into your diet for a healthy liver.
  • Bitter gourd
  • Probiotic yogurt
  • Onions
  • Lemon
  • Berries
  • Arugula
  • Artichokes
  • Leeks

How proteins may help in liver regeneration

How proteins may help in liver regenerationSimilar to the previous research mentioned, scientist at UC Davis further explored the use of proteins in liver regeneration. The identified protein is called PPARα and in mice models they found it to work quite quickly in liver regenerations.
What the researchers did uncover, though, is to boost PPARα in humans for quicker liver regeneration we require protein fibroblast factor 21 (FGF21). Author of the paper Yu-Jui Yvonne Wan said, “We found that FGF21 is a good rescuing molecule that facilitates liver regeneration and perhaps tissue repair. Our data suggests that FGF21 could help with liver regeneration, either after removal or after damage caused by alcohol or a virus.”
Through testing the researchers found that PPARα was more effective in liver regeneration in mice livers than in human ones. What they did find was that by adding FGF21, liver regeneration was boosted by making PPARα more effective. FGF21 is also beneficial in reducing insulin resistance, accelerating fat metabolism and reducing fatty liver disease in some animals.
Wan added, “We found that FGF21 is a good rescuing molecule that facilitates liver regeneration and perhaps tissue repair. Our data suggests that FGF21 could help with liver regeneration, either after removal or after damage caused by alcohol or a virus.”

Cell fundamental for liver regeneration found

Although it has been established that proteins work to promote liver regeneration, as of late more findings suggest a cell, too, is fundamental for liver regeneration.
Published in the journal Cell researchers uncovered cells called hybrid hepatocytes which are able to generate new tissues. By exposing mice to toxins researchers observed the role of hybrid hepatocytes. What they found was cancer did not develop in the new cells which were created by the hybrid hepatocytes. This prompted the researchers to further explore opportunities of hybrid hepatocytes.
Until science is capable of fully regenerating livers it’s important to maintain the health of yours as best as you can. Waiting lists for liver transplants are extremely long, so in order to keep your name off the list, enjoy the foods listed above which can promote a healthy liver and a healthy you.



Monday, 11 June 2012

Regenerating liver inside the Body


Dean of Invention: Re-Gen Revolution

Originaly posted on: 28 April 2012

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Dean of Invention: Growing New Organs Inside the Body (Series 1 Episode 8)

A doctor at the University of Pittsburgh finds a way to regenerate the liver inside the body cavity, an unprecedented feat!

Unfortunately, the video above finished a bit too early. In the report which was on Discovery Science broadcast on 15 April 2012 in Asia, it went on to show that the liver cells deposited themselves in the lymph nodes where they started to grow into mini livers in the mice, and taking on liver function capabilities. Hence the potential of growing new organs inside the body.

This programme was first shown in the UK in late 2010 and has probably been shown in many parts of the world. Catch it if you get an opportunity when shown or repeated.

Update on 3 June 2011: The programme is to be shown again on Sunday 10th June 2012 at 2200 hours on Astro Discovery Science Channel (554 in Malaysia).


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Updated on 11th June 2012:

3 medical institutions were highlighted on the programme:

a) Wake Forest Institute for Re-Generative Medicine

Surgeon Anthony Atala talked about using own body cells for growing body parts outside the body. Cells are coated onto a 'scaffold' in layers to form the organ. Organs grown included the bladder, heart valve, ear and skin.

From Wikipedia, the free encyclopedia:


Wake Forest Institute for Regenerative Medicine is a research institute affiliated with the Wake Forest School of Medicine and located at Winston-Salem, North Carolina, United States. Regenerative medicine is "a practice that aims to refurbish diseased or damaged tissue using the body's own healthy cells."[1] The institute opened its doors in May 2006 in an urban research downtown park in a 189,000-square-foot (17,600 m2) research building. The facility is part of the Piedmont Triad Research Park.[2][3]

Anthony Atala, M.D., is the Director of the Institute. He and many of his team came to North Carolina from the Laboratory for Tissue Engineering and Cellular Therapeutics at the Children's Hospital Boston and Harvard Medical School. Notable achievements announced at Wake Forest Institute have been the first lab-grown organ, a bladder, the artificial urinary bladder to be implanted into a human.[4][5] and stem cells harvested from the amniotic fluid of pregnant women. These stems cells are pluripotent, meaning they can be manipulated to differentiate into various types of mature cells that make up nerve, muscle, bone, and other tissues while avoiding the problems of tumor formation and ethical concerns that are associated with embryonic stem cells.[6]

http://en.wikipedia.org/wiki/Wake_Forest_Institute_for_Regenerative_Medicine



The following links were found on the web regarding the above institute:

Talks

Anthony Atala: Printing a human kidney

TED2011 Filmed and Posted Mar 2011



601,012 Views

Surgeon Anthony Atala demonstrates an early-stage experiment that could someday solve the organ-donor problem: a 3D printer that uses living cells to output a transplantable kidney. Using similar technology, Dr. Atala's young patient Luke Massella received an engineered bladder 10 years ago; we meet him onstage.

Anthony Atala asks, "Can we grow organs instead of transplanting them?" His lab at the Wake Forest Institute for Regenerative Medicine is doing just that -- engineering over 30 tissues and whole organs. Full bio »



Talks | TED Partner Series

Anthony Atala on growing new organs

TEDMED2009 Filmed Oct 2009 Posted Jan 2010



702,778 Views

Anthony Atala's state-of-the-art lab grows human organs -- from muscles to blood vessels to bladders, and more. At TEDMED, he shows footage of his bio-engineers working with some of its sci-fi gizmos, including an oven-like bioreactor (preheat to 98.6 F) and a machine that "prints" human tissue.

Anthony Atala asks, "Can we grow organs instead of transplanting them?" His lab at the Wake Forest Institute for Regenerative Medicine is doing just that -- engineering over 30 tissues and whole organs. Full bio »

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b) Weill Cornell Medical College, New York

The programme showed how blood and oxygen were introduced into the capillaries of the body parts using the cotton candy concept, mentioned in the above video.


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c) McGowan Institute for Re-Generative Medicine, University of Pittsburgh

Eric Lagasse was interviewed in the programme about his research on finding a way to regenerate the liver inside the body cavity.

The liver cells injected into the abdominal cavity of mice settled in the lymph nodes. The lymph nodes are incubator sites for producing immune system cells. One in ten lymph nodes produced more liver cells which took over carrying out the liver functions.

Eric Lagasse bio link:
http://www.mirm.pitt.edu/people/bios/lagasse.asp

Eric Lagasse Laboratory link:
http://www.mirm.pitt.edu/lagasse/default.asp


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