'Bogus' Herbal Supplements Fail Ingredient Test: Investigation

An investigation by the New York State Attorney General’s Office alleges that some store-brand herbal supplements sold in New York by Walmart, Walgreens, Target and GNC are "bogus" – in that they "could not be verified to contain the labeled substance, or ... were found to contain ingredients not listed on the labels." Some the ingredients that were detected include mustard and powdered rice.

• By TOM LLAMAS
 

Feb 3, 2015, 2:29 PM ET

New York State Attorney General Eric Schneiderman sent cease-and-desist letters, dated Monday, to the four retailers demanding they pull the supplements from their shelves and provide additional information about the products tested. Nearly 80 percent of the state’s test results found that the store-brand supplements tested did not contain what is listed on the label, according to a press release from Schneiderman's office.

“In a good number of cases, there was no organic material in the product,” said Marty Mack, Executive Deputy Attorney General for New York. “In some cases, it was sand.”

According to the findings, the store brands of Gingko Biloba and St. John’s Wort at all four stores did not test positive for either herb. Walmart, Walgreens and GNC’s versions of Ginseng and Echinacea also failed their ingredient tests.

Americans spend billions of dollars each year on herbal supplements, with the products extolling health and wellness benefits.

The four companies named in the investigation have released statements to ABC News regarding the situation. A Walgreen Co. spokesman released a statement to ABC News stating the company’s cooperation with the investigation.

“We take these issues very seriously and as a precautionary measure, we are in the process of removing these products from our shelves as we review this matter further,” the statement reads. “We intend to cooperate and work with the Attorney General.”

Target said it is looking into the issue.

“Without the full report, we can't comment other than to reiterate that Target is committed to providing high quality and safe products to our guests,” the statement reads.

While GNC is focused on cooperating with Schneiderman’s office, the company is also standing behind its products.

“GNC tests all of its products using validated and widely used testing methods, including those approved by governing bodies like the United States Pharmacopeia and the British Pharmacopeia,” a statement from GNC reads. “The methodology that we understand has been employed by the University of Guelph in testing our products has not been approved by the United States Pharmacopeia and may not be appropriate for the testing of these herbal products.”

In response, the attorney general's office reiterated it was "confident" in the testing methodology. "The industry has repeatedly attacked those who have conducted testing of these products in an attempt to verify their contents," a statement in response to GNC reads. "The University of Guelph has said that they are confident in their testing procedures and we are confident in our testing procedures. The burden is on the industry to prove that what on the labels is in the bottles."

Walmart initially told ABC News it would be “reaching out to the suppliers of these products to learn more.”

“At Walmart, we want our customers to have complete trust in the products they buy from our stores. It is our expectation that all suppliers conduct their business and produce products that are in full compliance with the law. Based on this notice, we are immediately reaching out to the suppliers of these products to learn more information and will take appropriate action.”

In an updated statement, the company said their suppliers did not report “any issues” with the products cited in the investigation, but the chain will take steps to remove the products from New York stores.

“Based on the testing performed by our suppliers we have not found any issues with the relevant products, but in order to comply with the Attorney General’s request we have stopped selling them in New York,” Carmen Bauza, senior vice president of Health & Wellness for Walmart U.S. said in the updated statement. “We take this matter very seriously and will be conducting side by side analysis because we are 100 percent committed to providing our customers safe products.” 

Full statement from GNC to ABC News: In response to your inquiry, GNC states the following: • We stand behind the quality, purity and potency of all ingredients listed on the labels of our private label products, including our GNC Herbal Plus line of products. • GNC tests all of its products using validated and widely used testing methods, including those approved by governing bodies like the United States Pharmacopeia and the British Pharmacopeia. • The methodology that we understand has been employed by the University of Guelph in testing our products has not been approved by the United States Pharmacopeia and may not be appropriate for the testing of these herbal products. • We will certainly cooperate with the Attorney General’s office in all appropriate ways.

http://abcnews.go.com/Health/bogus-herbal-supplements-fail-ingredient-test-investigation/story?id=28684472

P/S: Take note that this article is dated Feb 2015.

How Sugar Harms Your Brain Health and Drives Alzheimer’s Epidemic

July 24, 2014 

Story at-a-glance

• One in nine seniors over the age of 65 has Alzheimer’s, and the disease is now thought to be the third leading cause of death in the US, right behind heart disease and cancer
• A growing body of research suggests there’s a powerful connection between your diet and your risk of developing Alzheimer's disease, via similar pathways that cause type 2 diabetes
• Recent research shows that sugar and other carbohydrates can disrupt your brain function even if you’re not diabetic or have any signs of dementia
• Long-term, sugar can contribute to the shrinking of your hippocampus, which is a hallmark symptom of Alzheimer's disease
• The researchers propose that lowering glucose levels, even if they’re within the “normal” range, may have a positive influence on cognition in older people

By Dr. Mercola

Alzheimer's disease, a severe form of dementia, affects an estimated 5.2 million Americans, according to 2013 statistics.1

One in nine seniors over the age of 65 has Alzheimer's, and the disease is now thought to be the third leading cause of death in the US, right behind heart disease and cancer.

A growing body of research suggests there's a powerful connection between your diet and your risk of developing Alzheimer's disease, via similar pathways that cause type 2 diabetes.

Contrary to popular belief, your brain does not require glucose, and actually functions better burning alternative fuels, especially ketones, which your body makes in response to digesting healthy fats.

According to some experts, such as Dr. Ron Rosedale, Alzheimer's and other brain disorders may in large part be caused by the constant burning of glucose for fuel by your brain.

Alzheimer's disease was tentatively dubbed "type 3 diabetes" in early 2005 when researchers discovered that in addition to your pancreas, your brain alsoproduces insulin, and this brain insulin is necessary for the survival of brain cells.

Sugar Damages Brain Structure and Function

In your brain, insulin helps with neuron glucose-uptake and the regulation of neurotransmitters, such as acetylcholine, which are crucial for memory and learning. This is why reducing the level of insulin in your brain impairs your cognition.

Research2 has also shown that type 2 diabetics lose more brain volume with age than expected—particularly gray matter. This kind of brain atrophy is yet another contributing factor for dementia.

Studies have found that people with lower levels of insulin and insulin receptors in their brain often have Alzheimer's disease. But according to recent research published in the journal Neurology,3 sugar and other carbohydrates can disrupt your brain function even if you're not diabetic or have any signs of dementia.

To test their theory, they evaluated short- and long-term glucose markers in 141 healthy, non-diabetic, non-demented seniors. Memory tests and brain imaging were administered to assess their brain function and the actual structure of their hippocampus. As reported by Scientific American:4

"Higher levels on both glucose measures were associated with worse memory, as well as a smaller hippocampus and compromised hippocampal structure.

The researchers also found that the structural changes partially accounted for the statistical link between glucose and memory. According to study co-author Agnes Flöel, a neurologist at Charité, the results 'provide further evidence that glucose might directly contribute to hippocampal atrophy.'"

The findings suggest that even if you're not diabetic or insulin resistant (and about 80 percent of Americans fall into the latter category), sugar consumption can still disrupt your memory.

Long-term, it can contribute to the shrinking of your hippocampus, which is a hallmark symptom of Alzheimer's disease. (Your hippocampus is involved with the formation, organization, and storage of memories.)

The authors of the study suggest that "strategies aimed at lowering glucose levels even in the normal range may beneficially influence cognition in the older population."

'Normal' Blood Sugar Levels May Still Be High Enough to Cause Problems

Normally, a fasting blood sugar level between 100-125 mg/dl is diagnosed as a pre-diabetic state. A fasting blood sugar level of 90-100 is considered "normal." But in addition to the featured research, other studies have also found that brain atrophy occurs even in this "normal" blood sugar range.

Neurologist Dr. David Perlmutter, MD insists that being very strict in limiting your consumption of sugar and non-vegetable carbs is one of THE most important steps you can take to prevent Alzheimer's disease for this very reason.

He cites research from the Mayo Clinic, which found that diets rich in carbohydrates are associated with an 89 percent increased risk for dementia. Meanwhile, high-fat diets are associated with a 44 percent reduced risk

Sugar Lobby Threatens Organizations and Buries Science on Health Effects

Compelling research shows that your brain has great plasticity, which you control through your diet and lifestyle choices. Unfortunately, the American public has been grossly brainwashed by the sugar and processed food industries into believing that sugar is a perfectly reasonable "nutrient" that belongs in a healthy diet.  

Without accurate information, it's certainly more difficult to make health-affirming choices. Newsweek5 recently ran an article revealing just how far the sugar industry will go to defend its market share:

"According to a new report6 from the Center for Science and Democracy... industry groups representing companies that sell sweeteners, like the Sugar Association and the Corn Refiners Association... have poured millions of dollars into countering science that indicates negative health consequences of eating their products.

For example, when a University of Southern California study from 2013 found that the actual high fructose corn syrup content in sodas 'varied significantly' from the sugar content disclosed on soda labels, the Corn Refiners Association considered paying for its own counter research.

A consultant suggested that the counter research should only be published if the results aligned with their goal of disputing the USC study: 'If for any reason the results confirm [the University of Southern California study], we can just bury the data,' the consultant wrote, according to the report."

According to the Center for Science report, the Sugar Association even threatened the director general of the World Health Organization (WHO). WHO had published a paper on sugar, recommending a 10 percent limit on added sugars, stating that added sugars "threaten the nutritional quality of diets."

The Sugar Association shot off a letter to the director general, warning him that, unless WHO withdrew the study, the Sugar Association would persuade the US Congress to withdraw the WHO's federal funding. The following year, when WHO published its global health strategy on diet and health, there was no mention of the offending sugar study.

The Sugar Lobby Deserves Blame for Fueling Chronic Disease Epidemics

Indeed, despite overwhelming evidence showing that sugar, and processed fructose in particular, is at the heart of our burgeoning obesity and chronic disease epidemics, the sugar lobby has been so successful in its efforts to thwart the impact of such evidence that there's stillno consensus among our regulatory agencies as to the "factual" dangers of sugar...

According to Centers for Disease Control and Prevention (CDC) data,7 13 percent of the average American's diet is sugar. In the UK, a recently published report8 by the Scientific Advisory Committee on Nutrition (SACN) recommends limiting your added sugar intake to five percent, in order to avoid obesity and type 2 diabetes. They calculate this to be the equivalent of 25 grams of sugar (5-6 teaspoons) per day for women, and 35 grams (7-8 teaspoons) for men.

This matches my own recommendations for healthy, non-insulin resistant individuals—with one key difference. I recommend restricting sugar/fructose consumption to 25 grams from ALL sources, not just added sugar. This includes limiting your non-vegetable carbohydrates as well. Crazy enough, the Scientific Advisory Committee on Nutrition still recommends you get 50 percent of your daily energy intake in the form of starchy carbohydrates, which will undoubtedly and significantly raise your risk of insulin resistance. If you're insulin/leptin resistant, diabetic, overweight, or have high blood pressure, heart disease, or cancer, I recommend restricting your sugar/fructose consumption to a maximum of 15 grams per day from all sources, until your insulin/leptin resistance has been resolved.

Dietary Guidelines for Maintaining Healthy Brain Function and Avoiding Alzheimer's Disease

It's becoming increasingly clear that the same pathological process that leads to insulin resistance and type 2 diabetes may also hold true for your brain. As you over-indulge on sugar and grains, your brain becomes overwhelmed by the consistently high levels of glucose and insulin that blunts its insulin signaling, leading to impairments in your thinking and memory abilities, eventually causing permanent brain damage.

Additionally, when your liver is busy processing fructose (which your liver turns into fat), it severely hampers its ability to make cholesterol, an essential building block of your brain that is crucial for optimal brain function. Indeed, mounting evidence supports the notion that significantly reducing fructose consumption is a very important step for preventing Alzheimer's disease. 

Because of the very limited treatments, and no available cure as of yet, you're really left with just one solid solution, and that is to prevent Alzheimer's from happening to you in the first place. As explained by neurologist Dr. David Perlmutter, Alzheimer's is a disease predicated primarily on lifestyle choices; the two main culprits being excessive sugar and gluten consumption.

Another major factor is the development and increased consumption of genetically engineered (GE) grains, which are now pervasive in most processed foods sold in the US. The beauty of following my optimized nutrition plan is that it helps prevent and treat virtually ALL chronic degenerative diseases, including Alzheimer's. Dr. Perlmutter's book, Grain Brain, also provides powerful arguments for eliminating grains from your diet, particularly if you want to protect the health of your brain. In terms of your diet, the following suggestions may be among the most important for Alzheimer's prevention:

• Avoid sugar and refined fructose. Ideally, you'll want to keep your total sugar and fructose below 25 grams per day, or as low as 15 grams per day if you have insulin resistance or any related disorders. In one recent animal study, a junk food diet high in sugar resulted in impaired memory after just one week!9 Place recognition, specifically, was adversely affected.
As a general rule, you'll want to keep your fasting insulin levels below 3, and this is indirectly related to fructose, as it will clearly lead to insulin resistance. However, other sugars (sucrose is 50 percent fructose by weight), grains, and lack of exercise are also important factors. Lowering insulin will also help lower leptin levels which is another factor for Alzheimer's.
• Avoid gluten and casein (primarily wheat and pasteurized dairy, but not dairy fat, such as butter). Research shows that your blood-brain barrier, the barrier that keeps things out of your brain where they don't belong, is negatively affected by gluten. Gluten also makes your gut more permeable, which allows proteins to get into your bloodstream, where they don't belong. That then sensitizes your immune system and promotes inflammation and autoimmunity, both of which play a role in the development of Alzheimer's.
• Eat a nutritious diet, rich in folate, such as the one described in my nutrition plan. Vegetables, without question, are your best form of folate, and we should all eat plenty of fresh raw veggies every day. Avoid supplements like folic acid, which is the inferior synthetic version of folate.
• Increase consumption of all healthful fats, including animal-based omega-3. Beneficial health-promoting fats that your brain needs for optimal function include organic butter from raw milk, clarified butter called ghee, organic grass fed raw butter, olives, organic virgin olive oil and coconut oil, nuts like pecans and macadamia, free-range eggs, wild Alaskan salmon, and avocado.
Contrary to popular belief, the ideal fuel for your brain is not glucose but ketones. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy. The medium-chain triglycerides (MCTs) found in coconut oil are a great source of ketone bodies, because coconut oil is about 66 percent MCTs. In 2010, I published Dr. Mary Newport's theory that coconut oil might offer profound benefits in the fight against Alzheimer's disease. She has sincelaunched one of the first clinical trials of its kind to test this theory.
Also make sure you're getting enough animal-based omega-3 fats, such as krill oil. (I recommend avoiding most fish because, although fish is naturally high in omega-3, most fish are now severely contaminated with mercury.) High intake of the omega-3 fats EPA and DHA help by preventing cell damage caused by Alzheimer's disease, thereby slowing down its progression, and lowering your risk of developing the disorder.
• Optimize your gut flora by regularly eating fermented foods or taking a high-potency and high-quality probiotic supplement
• Eat blueberries. Wild blueberries, which have high anthocyanin and antioxidant content, are known to guard against Alzheimer's and other neurological diseases. 

Other Helpful Dietary Tips and Valuable Supplements

Another helpful tip is to reduce your overall calorie consumption, and/or intermittently fast. As mentioned above, ketones are mobilized when you replace carbs with coconut oil and other sources of healthy fats. A one-day fast can help your body to "reset" itself, and start to burn fat instead of sugar. As part of a healthy lifestyle, I prefer an intermittent fasting schedule that simply calls for limiting your eating to a narrower window of time each day. By restricting your eating to a 6-8 hour window, you effectively fast 16-18 hours each day. To learn more about intermittent fasting, please see this previous article.

Also be aware that when it comes to cholesterol levels and Alzheimer's, lower is NOT better. Quite the contrary. According toDr. Perlmutter, research shows that elderly individuals with the lowest cholesterol levels have the highest risk for Alzheimer's. They also have the highest risk for dying. As he says, the war on cholesterol is fundamentally inappropriate and harmful.

Finally, there's a short list of supplement recommendations worth noting for their specific benefits in preventing and treating dementia. So, although your fundamental strategy for preventing dementia should involve a comprehensive lifestyle approach, you may want to take special note of the following natural dietary agents. These four natural foods/supplements have good science behind them, in terms of preventing age-related cognitive changes:

1. Gingko biloba: Many scientific studies have found that Ginkgo biloba has positive effects for dementia. A 1997 study from JAMA showed clear evidence that Ginkgo improves cognitive performance and social functioning for those suffering from dementia. Another 2006 study found Ginkgo as effective as the dementia drug Aricept (donepezil) for treating mild to moderate Alzheimer's type dementia. A 2010 meta-analysis also found Ginkgo biloba to be effective for a variety of types of dementia.
2. Alpha lipoic acid (ALA): ALA has been shown to help stabilize cognitive functions among Alzheimer's patients and may slow the progression of the disease.
3. Vitamin B12: A small Finnish study published in the journal Neurology10 found thatpeople who consume foods rich in B12 may reduce their risk of Alzheimer's in their later years. For each unit increase in the marker of vitamin B12 the risk of developing Alzheimer's was reduced by two percent. Remember sublingual methylcobalamin may be your best bet here.

Lifestyle Strategies That Can Help Ward off Alzheimer's Disease

Lifestyle choices such as getting regular sun exposure and exercise, along with avoiding toxins, are also important factors when it comes to maintaining optimal brain health. Here are several of my lifestyle suggestions:

• Optimize your vitamin D levels with safe sun exposure. Strong links between low levels of vitamin D in Alzheimer's patients and poor outcomes on cognitive tests have been revealed. Researchers believe that optimal vitamin D levels may enhance the amount of important chemicals in your brain and protect brain cells by increasing the effectiveness of the glial cells in nursing damaged neurons back to health.
Vitamin D may also exert some of its beneficial effects on Alzheimer's through its anti-inflammatory and immune-boosting properties. Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation that is also associated with Alzheimer's.
• Exercise regularly. It's been suggested that exercise can trigger a change in the way the amyloid precursor protein is metabolized,11 thus, slowing down the onset and progression of Alzheimer's. Exercise also increases levels of the protein PGC-1alpha. Research has also shown that people with Alzheimer's have less PGC-1alpha in their brains12 and cells that contain more of the protein produce less of the toxic amyloid protein associated with Alzheimer's. I would strongly recommend reviewing the Peak Fitness Technique for my specific recommendations.
• Avoid and eliminate mercury from your body. Dental amalgam fillings, which are 50 percent mercury by weight, are one of the major sources of heavy metal toxicity. However, you should be healthy prior to having them removed. Once you have adjusted to following the diet described in my optimized nutrition plan, you can follow the mercury detox protocol and then find a biological dentist to have your amalgams removed.
• Avoid aluminum, such as antiperspirants, non-stick cookware, vaccine adjuvants, etc.
• Avoid flu vaccinations as most contain both mercury and aluminum, well-known neurotoxic and immunotoxic agents.
• Avoid anticholinergics and statin drugs. Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain nighttime pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers.
Statin drugs are particularly problematic because they suppress the synthesis of cholesterol, deplete your brain of coenzyme Q10 and neurotransmitter precursors, and prevent adequate delivery of essential fatty acids and fat-soluble antioxidants to your brain by inhibiting the production of the indispensable carrier biomolecule known as low-density lipoprotein.
• Challenge your mind daily. Mental stimulation, especially learning something new, such as learning to play an instrument or a new language, is associated with a decreased risk of Alzheimer's. Researchers suspect that mental challenge helps to build up your brain, making it less susceptible to the lesions associated with Alzheimer's disease.

[+] Sources and References

Go to Healthwise for more articles

http://articles.mercola.com/sites/articles/archive/2014/07/24/sugar-brain-function.aspx?

Telomeres: The New Key To Anti-Aging

 Dr. Isaac Eliaz | Jul 02, 2013

 

DNA leads a precarious existence. Each cell contains several feet of genetic material that must be packed very tightly to fit the allotted space. When cells divide, the DNA strands have to split apart, with every piece creating a new strand for each of the two new cells.

This process can be particularly treacherous and vulnerable to harmful mutations that distort the genetic material. Fortunately, the body has ways to protect the all-important DNA. One of the most important structures that safeguard DNA consists of what are called telomeres.

Located at the tips of each of our 46 chromosomes, telomeres help protect DNA and are particularly important during cell division. Telomeres have received a lot of notoriety due to their relationship with aging. These protective structures shorten with each cell division, exposing DNA to potential danger. In time, telomeres get too short to shield DNA. That’s when cells stop working, function poorly or, even worse, develop disease.

There’s a lot of research being conducted on ways to preserve telomeres. Much of this work focuses on telomerase, an enzyme that helps rebuild telomeres after cell division. Some researchers propose that boosting telomerase may be a way to preserve telomere function and increase longevity and health. However, there’s another side to the coin: Too much telomerase activity may be associated with cancer formation, because it allows cells to replicate uncontrollably. But other studies debunk this link.

What researchers are suggesting overall is that healthy telomere function, like so many other complex systems in the body, requires a careful balance. Furthermore, it’s becoming clear that telomere function is influenced by numerous environmental and lifestyle factors and that shortened telomeres can lead to a number of chronic, degenerative diseases. Obviously, more research is needed, but data suggests that preserving telomere health can play a role in maintaining long-term vitality.

Risky Business

Telomeres can be prematurely shortened by many factors. Environmental toxins, stress, smoking and an unhealthy diet play a part. Shortened telomeres have been linked to cancer, heart disease, inflammation, insulin resistance, osteoarthritis, obesity and dementia.

It’s not entirely clear whether shortened telomeres are causing these conditions. Still, there’s obviously a relationship. A study conducted at the University of Utah found that people with shorter telomeres have a shorter life expectancy. In particular, they seemed to be susceptible to heart disease and infections. A more comprehensive study conducted in Denmark showed that reduced length increases the chance of premature death by 25 percent.

Taking Action

Preserving telomeres is not a magic health bullet. If we eat poorly, smoke, drink heavily and neglect exercise, there’s no amount of telomere support that will guarantee protection.

On the other hand, if we develop a healthy lifestyle and control known disease markers, like blood pressure and chronic inflammation, supporting telomere length can complement these efforts.
As always, the starting point is diet and exercise. Eat plenty of fruits and vegetables, drink lots of filtered water, and choose lean proteins and healthy fats. Adopt a sustainable exercise program: brisk, 30-minute walks provide excellent cardiovascular support.

Don’t forget stress reduction. There are a number of studies linking stress to shortened telomeres. Again, we’re not sure whether this is cause or effect, but it hardly matters. We know that stress releases the hormone cortisol and can cause chronic inflammation along with other degenerative effects. On the other hand, a study from researchers in California found that positive feelings, such as those produced by meditation, seem to activate telomerase. They also found that people who sustained “good feelings” had healthier telomeres.

In other words, we should adopt activities that quiet the mind and help center us. Meditation, yoga, Tai Chi, walking in nature or swimming a few laps in the pool can all be beneficial.

Important Supplements

There are a wide variety of herbs and nutrients that have been linked to healthy telomeres. Astragalus has been used for centuries in traditional medicines. Recent research has shown that Astragalus boosts immune function. At present, at least two pharmaceutical companies are focusing on this herb’s potential to preserve telomeres.

Vitamins also seem to play a role. Several vitamins, specifically vitamin D, appear to boost telomere length. Antioxidants, which can be found in vitamins and other sources, are also important. Oxidative stress is linked with shortened telomeres; arming the body against this pro-inflammatory process is always beneficial.

Long touted for its ability to boost heart and cognitive function, omega-3 fatty acids have also been linked with telomere length. In one study, lower omega-3 levels in the bloodstream were associated with accelerated telomere shortening.

As noted, environmental toxins such as heavy metals may play a significant role, as well as being harmful to health in other ways. There are a couple of supplement formulas I recommend to help the body remove these pollutants. A comprehensive, botanical detoxification formula containing vitamins, minerals, astragalus, gingko, antioxidants and other botanicals helps rid the body of toxins and may preserve telomere health.

I also recommend modified citrus pectin (MCP), which has long been used to remove heavy metals and other toxins. In addition, MCP helps reduce levels of an inflammatory protein often associated with cardiovascular disease and cancer.

This is by no means the final word on telomeres. New research will further illuminate these key structures, helping to guide our efforts to preserve long-term health. Meanwhile, a simple common-sense approach that includes a healthy diet, exercise, stress reduction and focused supplementation can go a long way toward preserving telomeres and promoting health and longevity.

For more health and wellness information, visit www.dreliaz.org.

http://easyhealthoptions.com/alternative-medicine/telomeres-the-new-key-to-anti-aging/

Vitamins Offer Hope for Alzheimer's

June 13, 2013

Story at-a-glance

• Alzheimer's disease is currently at epidemic proportions, with 5.4 million Americans—including one in eight people aged 65 and over—living with it. There is no known cure, and few truly effective treatments
• Research suggests the best hope is in prevention focusing on diet, exercise and staying mentally active.
• Two recent studies show that compounds in cinnamon, and vitamins B12, B6, and folate may delay the onset and/or slow progression of the disease
• Vitamin treatment consisting of 0.8 mg folic acid, 20 mg vitamin B6 and 0.5 mg vitamin B12 slowed shrinkage of the whole brain volume over the course of two years
• The vitamin treatment also reduced, by as much as seven-fold, the cerebral atrophy in certain brain regions that are particularly vulnerable to damage associated with Alzheimer’s disease
• Research suggests that being exposed to general anesthesia can increase the risk of dementia in the elderly by as much as 35 percent

 

By Dr. Mercola 

In the United States, Alzheimer's disease is currently at epidemic proportions, with 5.4 million Americans—including one in eight people aged 65 and over—living with the disease, according to the Alzheimer's Association's 2011 Alzheimer's Disease Facts and Figures¹. 

By 2050, this is expected to jump to 16 million, and in the next 20 years, it is projected that Alzheimer's will affect one in four Americans, rivaling the current prevalence of obesity and diabetes.  

There is still no known cure for this devastating disease, and very few treatments. Alzheimer's drugs are often of little to no benefit at all, which underscores the importance of prevention throughout your lifetime. 

Research repeatedly suggests the best hope for patients lies in prevention through optimal diet, exercise and staying socially and mentally active. As recently reported by Forbes²:

“[A] new study in Science suggested that last year’s ‘breakthrough’ pharmaceutical, bexarotene (Targretin) – a cancer drug that had initially received wide publicity for helping break up the plaques in Alzheimer’s – doesn’t seem to do this very well at all, and can have significant adverse side effects for the patient.

‘Something happened in that initial report – either something technically or otherwise, which we can’t put our hands on at this point in time,” study author Sangram Sisodia told US News & World Report. ‘Something is seriously wrong.’

While memory loss is common among Westerners, it is NOT a "normal" part of aging. Research has shown that even mild "senior moments" are caused by the same brain lesions associated with Alzheimer's disease and other forms of dementia. These cognitive changes are by no means inevitable!  

People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it's entirely possible to prevent the damage from occurring in the first place. At the end of this article, I share my best tips for maintaining healthy brain function well into old age. 

In recent years, researchers studying natural compounds have offered new hope. For example, two recent studies suggest that compounds in cinnamon, as well as vitamins B12, B6, and folate may delay the onset and/or slow progression of the disease.

The Promise of Cinnamon and Vitamins in the Fight Against Alzheimer’s Disease 

The first study in question, published in the Journal of Alzheimer’s Disease³, found that cinnamaldehyde and epicatechin, two compounds found in cinnamon, have an inhibitory effect on the aggregation of a particular protein called tau. Tau plays a large role in the structure and function of neurons.  

But while a normal part of cell structures, this protein can begin to accumulate, forming “neurofibrillary tangles” that are a hallmark of Alzheimer’s disease. Both compounds were found to protect tau from oxidative damage that can lead to dysfunction. 

Donald Graves, adjunct professor in UCSB's Department of Molecular, Cellular, and Developmental Biology and co-author of the study explained the protective process to Medical News Today⁴:

"'Take, for example, sunburn, a form of oxidative damage. If you wore a hat, you could protect your face and head from the oxidation. In a sense this cinnamaldehyde is like a cap. While it can protect the tau protein by binding to its vulnerable cysteine residues, it can also come off,' Graves added, which can ensure the proper functioning of the protein.”

It’s interesting to note that there’s a high correlation between type 2 diabetes and Alzheimer's disease. Some even believe Alzheimer’s may be a form of brain diabetes. Insulin and insulin receptors in your brain are crucial for learning and memory, and it’s known that these components are lower in people with Alzheimer’s disease.  

In addition to the above findings, cinnamon has also been found to have beneficial effects on blood glucose management in type 2 diabetics. This is one of the reasons I include cinnamon in my healthy coconut candy recipe.

B Vitamins Again Show Promise in Alzheimer’s Prevention 

The other study, published in Proceedings of the National Academy of Sciences⁵, found that vitamins B6, B12, and folic acid may help slow the progression of the disease, confirming and supporting previous studies. As reported in the featured article⁶:

“The fact that B-family vitamins may play a significant role in dementia, or more specifically in warding it off has been consistently illustrated. What is news from the current study, however, is that high-dose B-vitamin treatment in people at risk for the disease ‘slowed shrinkage of whole brain volume,’ and especially reduced shrinkage in areas known to be affected in Alzheimer’s disease.”

The 156 study participants, all of whom were over the age of 70, were diagnosed with mild cognitive impairment. This, along with midlife hypertension, midlife obesity and diabetes, is a known risk factor for Alzheimer’s. One group of participants received a placebo while the other received high-dose B-vitamin treatment consisting of:

• 0.8 mg folic acid
• 20 mg vitamin B6
• 0.5 mg vitamin B12

It is important to note that vitamin B12 comes in many forms and it is typically injected because it is not absorbed well by most people, especially in the elderly who need it most. This is due to it being one of the largest vitamins known. The most common form is cyanocobalamin but a better from would be methylcobalamin. A better alternative to B12 injections would also be sublingual sprays, which are absorbed very similarly to the injections.  

The treatment effectively slowed shrinkage of the whole brain volume over the course of two years. It also reduced, by as much as seven-fold, the cerebral atrophy in certain brain regions that are particularly vulnerable to damage associated with Alzheimer’s disease.  

Another major boon: The supplements cost less than 50 cents a day and are readily available in pharmacies and health-food stores. In the placebo group, higher homocysteine levels at baseline were associated with faster atrophy in these same regions. According to the researchers⁷:

“We... show that the beneficial effect of B vitamins is confined to participants with high homocysteine... and that, in these participants, a causal Bayesian network analysis indicates the following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in gray matter atrophy, thereby slowing cognitive decline.

Our results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline.”

Dr. A. David Smith, professor emeritus of pharmacology at Oxford University, founding director of the Oxford Project to Investigate Memory and Ageing, and senior author of the study told Bloomberg News⁸ that this B-vitamin treatment is “the first and only disease-modifying treatment that’s worked. We have proved the concept that you can modify the disease.” This shouldn’t come as a surprise to anyone who understands that without proper nutrition and exercise, your brain will be increasingly vulnerable to damage with age...

Vitamin B Cocktail Already Used for Dementia Prevention in Sweden 

Three years ago, the same group of researchers showed that the atrophy rate in patients’ whole brains was reduced by about 30 percent in those taking the vitamin cocktail⁹. The atrophy rate was even higher—53 percent—in those who had elevated homocysteine levels, a benefit that was reconfirmed in the featured study. According to Bloomberg¹⁰:

“The studies, known as Vitacog, were funded by seven charities and government agencies and vitamin maker Meda AB of Solna, Sweden. Smith is an inventor on three patents held by Oxford University for B vitamin formulations to treat Alzheimer’s disease... Vitamin B12 is found in liver, fish and milk and folic acid in fruit and vegetables. Deficiency of folate and B vitamins is already linked to dementia...

Doctors in Sweden began measuring homocysteine in people who report declining memory about two years ago, said [Johan] Lokk [professor and head physician in the geriatric department at Karolinska University Hospital in Sweden, who wasn’t involved in the study]...

Swedish patients with high homocysteine are given folic acid and B vitamins, even if they aren’t deficient. ‘We think the increased homocysteine level could be deleterious to the brain,’ Lokk said. ‘We wanted to be on the offensive in diagnosing and treating patients. In our opinion, it is harmless and cheap.'”

General Anesthesia Could Increase Risk of Dementia in Elderly by 35 Percent 

Related research suggests that being exposed to general anesthesia can increase the risk of dementia in the elderly by as much as 35 percent. The research was presented at the annual congress of the European Society of Anesthesiology (ESA). As reported by Medical News Today¹¹:

“Postoperative cognitive dysfunction, or POCD, could be associated with dementia several years later. POCD is a common complication in elderly patients after major surgery. It has been proposed that there is an association between POCD and the development of dementia due to a common pathological mechanism through the amyloid β peptide. Several experimental studies suggest that some anesthetics could promote inflammation of neural tissues leading to POCD and/or Alzheimer's disease (AD) precursors including β-amyloid plaques and neurofibrillary tangles.”

Participants aged 65 and over were followed for a total of 10 years. Participants exposed to at least one general anesthetic over the follow-up had a 35 percent increased risk of developing a dementia compared to those who were not exposed to anesthesia. According to lead researcher Dr. Francois Sztark¹²:

"These results are in favor of an increased risk for dementia several years after general anesthesia. Recognition of POCD is essential in the perioperative management of elderly patients. A long-term follow-up of these patients should be planned."

Tips for Avoiding Alzheimer's Disease 

The beauty of following my revised Nutrition Plan is that it helps treat and prevent all chronic degenerative diseases, from the common ones like heart disease, diabetes, obesity and Alzheimer's to the ones you have never heard of or can't even pronounce. So please read the Plan as soon as you can. It is divided into three helpful sections, Beginner, Intermediate and Advanced to help you start at the right level. 

The plan is the first step in addressing Alzheimer's disease, which is currently at epidemic proportions, with 5.4 million Americans – including one in eight people aged 65 and over – living with the disease.  

Remember, while memory loss is indeed common among Westerners, it is NOT a "normal" part of aging, and cognitive changes are by no means inevitable. People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it's entirely possible to prevent the damage from occurring in the first place… and one of the best ways to do this is by leading a healthy lifestyle.

• Sugar and Fructose. Ideally, you’ll want to keep your sugar levels to a minimum and your total fructose below 25 grams per day, or as low as 15 grams per day if you have insulin resistance or any related disorders.
• Improve magnesium levels. There is some exciting preliminary research strongly suggesting a decrease in Alzheimer symptoms with increased levels of magnesium in the brain. Unfortunately, most magnesium supplements do not pass the blood brain levels, but a new one, magnesium threonate, appears to and holds some promise for the future for treating this condition and may be superior to other forms.
• Optimize your vitamin D levels with safe sun exposure. Strong links between low levels of vitamin D in Alzheimer's patients and poor outcomes on cognitive tests have been revealed. Researchers believe that optimal vitamin D levels may enhance the amount of important chemicals in your brain and protect brain cells by increasing the effectiveness of the glial cells in nursing damaged neurons back to health.Vitamin D may also exert some of its beneficial effects on Alzheimer's through its anti-inflammatory and immune-boosting properties. Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation that is also associated with Alzheimer's.
• Keep your fasting insulin levels below 3. This is indirectly related to fructose, as it will clearly lead to insulin resistance. However other sugars (sucrose is 50 percent fructose by weight), grains and lack of exercise are also important factors. Lowering insulin will also help lower leptin levels which is another factor for Alzheimer’s.
• Vitamin B12: In addition to the research presented above, a small Finnish study published in the journal Neurology¹³ also found that people who consume foods rich in B12 may reduce their risk of Alzheimer's in their later years. For each unit increase in the marker of vitamin B12, the risk of developing Alzheimer's was reduced by two percent. Remember sublingual methylcobalamin may be your best bet here.
• Eat a nutritious diet, rich in folate, such as the one described in my nutrition plan. Vegetables, without question, are your best form of folate, and we should all eat plenty of fresh raw veggies every day. Avoid supplements with folic acid, which is the inferior synthetic version of folate.
• High-quality animal-based omega-3 fats, such as krill oil. (I recommend avoiding most fish because, although fish is naturally high in omega-3, most fish are now severely contaminated with mercury.) High intake of the omega-3 fats EPA and DHA help by preventing cell damage caused by Alzheimer's disease, thereby slowing down its progression, and lowering your risk of developing the disorder.
• Avoid and eliminate mercury from your body. Dental amalgam fillings, which are 50 percent mercury by weight, are one of the major sources of heavy metal toxicity. However you should be healthy prior to having them removed. Once you have adjusted to following the diet described in my optimized nutrition plan, you can follow the mercury detox protocol and then find a biological dentist to have your amalgams removed.
• Avoid aluminum, such as antiperspirants, non-stick cookware, vaccine adjuvants, etc.
• Exercise regularly. It's been suggested that exercise can trigger a change in the way the amyloid precursor protein is metabolized¹⁴, thus, slowing down the onset and progression of Alzheimer's. Exercise also increases levels of the protein PGC-1alpha. Research has also shown that people with Alzheimer's have less PGC-1alpha in their brains¹¹ and cells that contain more of the protein produce less of the toxic amyloid protein associated with Alzheimer's. I would strongly recommend reviewing the Peak Fitness Technique for my specific recommendations.
• Avoid flu vaccinations as most contain both mercury and aluminum, well-known neurotoxic and immunotoxic agents.
• Eat blueberries. Wild blueberries, which have high anthocyanin and antioxidant content, are known to guard against Alzheimer's and other neurological diseases. Like any fruit though, avoid excesses here.
• Challenge your mind daily. Mental stimulation, especially learning something new, such as learning to play an instrument or a new language, is associated with a decreased risk of Alzheimer's. Researchers suspect that mental challenge helps to build up your brain, making it less susceptible to the lesions associated with Alzheimer's disease.
• Avoid anticholinergic and statin drugs. Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain nighttime pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers.

Statin drugs are particularly problematic because they suppress the synthesis of cholesterol, deplete your brain of coenzyme Q10 and neurotransmitter precursors, and prevent adequate delivery of essential fatty acids and fat-soluble antioxidants to your brain by inhibiting the production of the indispensable carrier biomolecule known as low-density lipoprotein.

Other Natural Treatments for Your Anti-Alzheimer's Arsenal

Finally, there are a few other nutritional recommendations worth noting for their specific benefits in preventing and treating dementia. So, although your fundamental strategy for preventing dementia should involve a comprehensive lifestyle approach, you may want to consider adding a few of these natural dietary agents to your anti-Alzheimer's arsenal.  

These four natural foods/supplements have good science behind them, in terms of preventing age-related cognitive changes:

1. Coconut Oil: The primary fuel your brain needs for energy is glucose. However, your brain is able to run on more than a single type of fuel, one being ketones (ketone bodies), or ketoacids. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy.The medium-chain triglycerides (MCT) found in coconut oil are GREAT source of ketone bodies, because coconut oil is about 66 percent MCTs. In fact, ketones appear to be the preferred source of brain food in patients affected by diabetes or Alzheimer's.
2. Astaxanthin is a natural pigment with unique properties and many clinical benefits, including some of the most potent antioxidant activity currently known. As a fat-soluble nutrient, astaxanthin readily crosses your blood-brain barrier. One study¹⁵ found it may help prevent neurodegeneration associated with oxidative stress, as well as make a potent natural "brain food."The molecules of astaxanthin neutralize free radicals and other oxidants without being destroyed or becoming pro-oxidants themselves in the process. It's is a unique molecule whose shape allows it to precisely fit into a cell membrane and span its entire width. In this position, astaxanthin can intercept potentially damaging molecules before they can damage your cells.
   You can get some astaxanthin by taking krill oil, which is a fantastic omega-3 fat supplement. But you can boost your astaxanthin even MORE by adding a pure astaxanthin supplement to your nutritional regimen. For optimal absorption, make sure to take krill oil and/or astaxanthin with a fat-containing meal, since both are fat-soluble.
3. Gingko biloba: Many scientific studies have found that Gingko biloba has positive effects for dementia. Gingko, which is derived from a tree native to Asia, has long been used medicinally in China and other countries. A 1997 study from JAMA showed clear evidence that Gingko improves cognitive performance and social functioning for those suffering from dementia.Research since then has been equally promising. One study in 2006 found Gingko as effective as the dementia drug Aricept (donepezil) for treating mild to moderate Alzheimer's type dementia. A 2010 meta-analysis found Gingko biloba to be effective for a variety of types of dementia.
4. Alpha lipoic acid (ALA): ALA can stabilize cognitive functions among Alzheimer's patients and may slow the progression of the disease.

[-] Sources and References

• ¹ Alzheimer's Association 2011 Alzheimer's Disease Facts and Figures
• ² Forbes May 24, 2013
• ³ Journal of Alzheimer’s Disease 2013 Mar 26. [Epub ahead of print]
• ⁴ Medical News Today May 28, 2013
• ⁵ Proceedings of the National Academy of Sciences May 20, 2013
• ⁶ Forbes May 24, 2013
• ⁷ Proceedings of the National Academy of Sciences May 20, 2013
• ⁸ Bloomberg May 20, 2013
• ⁹ Bloomberg May 20, 2013
• ¹⁰ Bloomberg May 20, 2013
• ¹¹ Medical News Today June 1, 2013
• ¹² Medical News Today June 1, 2013
• ¹³ Neurology October 19, 2010: 75(16); 1402-3
• ¹⁴ Journal of Neuroscience, April 27, 2005: 25(17); 4217-4221
• ¹⁵ Forum Nutr April 2009

http://articles.mercola.com/sites/articles/archive/2013/06/13/alzheimers-dementia-treatment.aspx?