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Showing posts with label Cancer - Bone. Show all posts
Showing posts with label Cancer - Bone. Show all posts

Wednesday, 27 January 2021

Aplidin: Cancer Drug Treats COVID-19 27.5x Better Than Remdesivir

Groundbreaking COVID-19 Treatment Found In Unexpected Cancer Drug

By Sissi Cao • 01/27/21 10:20am

Aplidin comes from a type of sea squirts, marine animals that look like plants. Reinhard Dirscherl/ullstein bild via Getty Images


An unexpected COVID-19 drug derived from a rare sea animal and historically used to treat cancer is found to be 27.5 times more effective than the Gilead Sciences’ popular coronavirus drug remdesivir, a study published in the journal Science on Monday revealed.

The treatment, known as Aplidin or Plitidepsin, is developed by the Spanish drug company PharmaMar. It has clinical approval in some countries, such as Australia, for treating multiple myeloma, a form of bone marrow cancer. The drug was identified as a potential COVID-19 treatment in March 2020 by a team of scientists at the University of California, San Francisco. Since then, it has completed phase 1 and phase 2 clinical trials and is expected to enter a phase 3 trial before seeking regulatory approval.

Aplidin comes from ascidian, also known as sea squirts, a kind of marine animal with some primitive vertebrate features and tubular openings that allow them to draw in and squirt out water. The particular type of sea squirt used to make Aplidin, called Aplidium albicans, is found only in the waters around the Spanish island of Ibiza.

The discovery of Aplidin’s effect in treating COVID-19 was not a result of random screening, like a lot of lab tests in the early days of the pandemic. Scientists at UC San Francisco found the drug by looking for existing treatments that would protect the specific human proteins targeted by the coronavirus.

“This was data-driven instead of just randomly screening drugs,” Nevan Krogan, a molecular biologist at UC San Francisco and a lead author of the study in Science, told Green Bay Press Gazette. “If you target a human protein that the virus needs, the virus will never mutate away from being reliant on that human protein.”

It’s unusual to test cancer drugs on viruses partly because of their potential harm to human cells. Fortunately, no serious side effects has been reported from Aplidin trials. The drug has been tested in a few dozen COVID-19 patients in Spain.

Krogan also noted that COVID-19 patients require substantially lower doses of Aplidin and shorter treatment period than cancer patients do.

Whether the drug can be introduced as an alternative to existing COVID-19 treatments depends on the large-scale phase 3 trial. But one limitation of Aplidin is that it can only be administered at a hospital, potentially making it difficult to reach a large base of patients.

Last week, a related study (yet to be peer-reviewed) on Aplidin by scientists at University College London found that the drug is equally effective at combating the new COVID-19 variant recently discovered in Britain. Lab tests showed that Aplidin was effective when used against two different human lung and epithelial cells infected with the new viral strain. 

https://observer.com/2021/01/aplidin-covid-drug-cancer-treatment/



Searches related to aplidin (plitidepsin)



UCSF QBI and Icahn School of Medicine at Mount Sinai ...

www.globenewswire.com › news-release › 2021/01/25
3 days ago — Plitidepsin shows potent anti-viral effect in preclinical models of original ... data showing the promise and potential of Aplidin® (plitidepsin), ...

Aplidin (plitidepsin) is a novel anti-myeloma agent with potent ...

www.researchgate.net › publication › 333055960_Aplidi...
Oct 31, 2020 — Request PDF | Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts ...

Plitidepsin - A novel Anti-cancer Agent Possibly Active Against ...

www.oncozine.com › News
Mar 16, 2020 — Plitidepsin, known as Aplidin®, an anticancer drug being developed by PharmaMar (Spain) show activity against coronavirus HCoV-229E and ...

In vitro promise of Aplidin for COVID-19 sends PharmaMar ...

www.thepharmaletter.com › article › in-vitro-promise-o...
Mar 13, 2020 — Aplidin (plitidepsin) is a compound that is currently approved in Australia for the treatment of multiple myeloma, having been rejected by the ...

PharmaMar plots Phase III trial after Aplidin shows promise in ...

www.thepharmaletter.com › article › pharmamar-plots-...
Oct 16, 2020 — The company had just announced that its APLICOV-PC clinical trial of Aplidin (plitidepsin) for the treatment of adult patients with COVID-19, ...

Marine Drugs | Free Full-Text | Phase II Randomized Study of ...

www.mdpi.com › ...
Phase II Randomized Study of Plitidepsin (Aplidin), Alone or in Association with L-carnitine, in Patients with Unresectable Advanced Renal Cell Carcinoma. by.
by P Schöffski · ‎2009 · ‎Cited by 34 · ‎Related articles

Cancer drug derived from sea squirts outperforms remdesivir ...

www.fiercebiotech.com › research › cancer-drug-extrac...
1 day ago — Scientists found PharmaMar's myeloma drug plitidepsin, derived from ... PharmaMar's plitidepsin, approved under the brand name Aplidin in ...

Aplidin to the rescue? Promising new COVID drug 'cuts viral ...

www.thesouthafrican.com › news › what-is-aplidin-new...
2 days ago — Aplidin, otherwise known as plitidepsin, is used to treat multiple myeloma and other cancer-related diseases. · Preliminary results claim it is ' ...

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Healthwise: Posted by Healthticket at 9:42:00 pm
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Labels: Aplidin, Cancer - Bone, Coronavirus, COVID-19, Covid-19 treatment, Myeloma, New Treatment, Remdesivir

Wednesday, 18 September 2019

The Most Dreaded Development in Cancer – and How to Prevent It

Just about the worst news a patient can get is that cancer cells have spread from the original tumor to other parts of the body. This process, called metastasis, does not have a good prognosis.

By Lee Euler / May 11, 2019


Early stage cancer is almost always treatable and you can often get rid of it altogether. Metastatic cancer – the more advanced stage — is a much more serious problem.
So you want to do everything you can to prevent metastasis or slow it down if you’ve got it. Fortunately, there’s a lot. . . and most of the options would benefit all of us whether we have cancer or not.
A study at the Brain Metastasis Group at the Spanish National Cancer Research Center shows that silibinin, an extract from the herb milk thistle, can reduce brain lesions linked to cancer metastases. And unlike most conventional treatments for cancer, silibinin doesn’t cause harmful side effects.
The brain is a common target of cancer cells looking for new sites to colonize. According to the Spanish researchers, from 10% to 40% of cancerous tumors in the body lead to metastases that invade the brain — with often fatal results.
Until now, the primary conventional treatment for these brain tumors has been surgery, radiotherapy and immunotherapy. But only about one of five cancer patients successfully recover with the help of those methods.
Special mechanism blocks metastasis
A big problem, the Spanish researchers found, is that astrocytes, immune cells that roam the brain, can help the cancer cells survive in brain tissue. But astrocytes are only the evil accomplices of cancer when one of their genes – called STAT3 – is activated.1
Silibinin can block this activation.
And when the investigators tested silibinin on people with lung cancer, they found that 75% of the time the herbal extract helped slow the development of metastatic tumors in the brain. Plus, survival time in this group of patients was four times that of people who didn’t receive silibinin.
There are many milk thistle products available on the market. My quick search did not turn up a pure silibinin supplement, and I don’t know how rich the general milk thistle supplements are in the specific silbinin extract. But I did find a Life Extension product called European Milk Thistle: Silymarin-Silibinins-Isosilybin A & B that specifically claims to contain this compound.
Turn off the lights
An easy, do-it-yourself way to lower the risk of cancer spreading is to make sure you sleep in a totally dark room at night.
That’s right – all you have to do is make sure your bedroom is pitch black at night. Researchers at Tulane have demonstrated that if somebody with breast cancer sleeps in a room that is even dimly lit, the exposure to light can increase the risk that cancer will spread into their bones.
You need darkness at night to help the daily circadian rhythms of your cells function properly and prevent the migration of cancer cells.2
“Exposure to dim light at night induces circadian disruption, which then increases the formation of bone metastatic breast cancer,” says researcher Muralidharan Anbalagan, who teaches at the Tulane University School of Medicine.
“This is important,” he added, “as many patients with breast cancer are likely exposed to light at night as a result of lack of sleep, stress, excess light in the bedroom from mobile devices and other sources, or night shift work.”
By keeping light out of the room you sleep in, you encourage the secretion of the anti-cancer hormone melatonin. “Our research identified the importance of an intact nocturnal circadian melatonin anti-cancer signal in suppressing bone-metastatic breast tumor growth,” says Dr. Anbalagan.
Eating habits that help prevent metastasis
What you eat and drink also affects your metastatic risk. According to biomedical engineers at Duke University, anyone with cancer should avoid foods that contain high-fructose corn syrup.
Of course, I believe — and there’s plenty of research to back this up — that anyone who wants to be healthy should avoid food and drinks containing corn syrup.
According to the Duke studies, when cancer cells start to roam, they may seek out the liver to feast on, because fructose accumulates in that organ if your diet has been rich in high-fructose corn syrup.
The Duke study focused on cancer cells from tumors in the colon. The researchers found that although these wandering cancer cells are still genetically identical to what they were in the digestive tract, when they sense fructose in the liver, they undergo epigenetic effects – genes are activated that allow the cancer cells to gorge on the liver’s supply of fructose.3
“Genetically speaking, colon cancer is colon cancer no matter where it goes,” says researcher Xiling Shen, “but that doesn’t mean that it can’t respond to a new environment (like the liver). We had a hunch that such a response might not be genetic, but metabolic in nature.”
Dr. Shen notes that certain metabolic genes became more active in liver metastases than they were in the original primary tumor. It seems that when the liver has been stocking up on fructose, the rich pickings stimulate the genes in the cancer cells that help them use fructose to fuel their functions.
So if you’ve been eating the typical American diet, full of soft drinks and other sweet treats flavored with high fructose corn syrup, you are filling your body with cancer’s favorite food.
“When cancer cells get to the liver, they’re like a kid in a candy store,” warns Dr. Shen. “They use this ample new energy supply to create building blocks for growing more cancer cells.”
Control stress to control cancer
While folks who study cancer have long suspected that stress can increase your risk for the spread of cancer, it’s only within the last year or so that researchers have started to untangle some of the specific factors that lead from stress to metastasis.
In lab tests on breast cancer conducted at the University of Basel in Switzerland, researchers discovered that the stress hormones cortisol and corticosterone interact with receptors on cancer cells that help the cells colonize other organs. The hormones also help the cells survive and proliferate in various organs around the body.4
At the same time, researchers at the University of Illinois have found that epinephrine, another stress hormone, initiates a whole series of biochemical reactions that spurs on the growth of breast cancer and encourages its metastatic spread.5
These researchers conclude that controlling stress is a key way to control the spread of cancer. The Basel researchers suggest exercising along with relaxation techniques like meditation to limit stress. And findings by the scientists in Illinois indicate that vitamin C may help. Their lab tests found evidence that vitamin C may be able to shrink metastatic tumors.
Don’t wait to adopt these healthy habits
I think that when researchers perform more studies on how to protect against metastases, they’ll probably also find that eating a diet filled with fruits and vegetables can up the body’s defenses against metastases. So far, only a few studies have found that this kind of diet reduces your risk of aggressive cancer. The evidence is not quite definitive.6 But I wouldn’t wait to adopt a diet rich in fresh produce.
And for sure it’s a good idea to sleep in a dark bedroom, take some vitamin C, and control stress through exercise and meditation. Those habits all have multiple health benefits along with their anti-cancer characteristics.
I also feel confident in recommending regular milk thistle supplementation. It’s healthy for a whole list of reasons besides its effect on cancer. I take a daily milk thistle supplement myself.

References:

  1. https://www.ncbi.nlm.nih.gov/pubmed/29892069
  2. https://www.endocrine.org/news-room/2019/endo-2019—breast-cancer-may-be-likelier-to-spread-to-bone-with-nighttime-dim-light-exposure
  3. https://www.ncbi.nlm.nih.gov/pubmed/29706565
  4. https://www.ncbi.nlm.nih.gov/pubmed/30867597
  5. https://www.ncbi.nlm.nih.gov/pubmed/30688660
  6. https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31653
https://www.cancerdefeated.com/the-most-dreaded-development-in-cancer-and-how-to-prevent-it/
Healthwise: Posted by Healthticket at 4:28:00 pm
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Labels: Anti-cancer, Brain Tumor, Cancer - Bone, Cancer - Brain, Cancer - Breast, Cancer - Liver, Cancer fighting, Cancer risk, Cancerdefeated.com, Life Extension, Metastasis, Milk Thistle, MUST READ, Silybin, Stress

Saturday, 18 July 2015

Itching After a Shower and Other Surprising Cancer Symptoms

ItchingCertain cancer symptoms almost always prompt a visit to the doctor. A breast lump. A mole that changes in size, shape or color. Blood in the stool.
But there are other symptoms that most people ignore.

June 15, 2015

Startling new finding: In a study published in British Journal of General Practice, nearly half of people with a warning sign of cancer decided not to see a doctor about it, often because they thought the symptom was insignificant.
For the following symptoms, your first step is to visit your primary care physician who can perform the appropriate tests and/or refer you to a specialist.
Important: If you have any one of these symptoms in isolation, the likelihood of you having cancer is less than 1%. That doesn’t mean you should dismiss the symptom. But it does mean that you shouldn’t panic if it shows up.

HEARTBURN

Most likely cause: Gastroesophageal reflux disease (GERD).
But it could be a sign of: Esophagus or stomach cancer. Symptoms of heartburn can include burning pain or discomfort in the stomach, upper ­abdomen, chest and/or throat…and/or excessive burping, bloating or nausea after eating. If those symptoms are chronic, it’s time to see a doctor for a workup. You might have Barrett’s esophagus, a precancerous condition that is triggered by chronic inflammation and increases the risk for esophageal cancer. Or you might have H. pylori, a bacterial infection of the stomach that increases your risk for stomach cancer (and ulcers)—but is easily treatable with a two-week treatment that includes antibiotics and possibly a proton-pump inhibitor.
More on Coping with Cancer
  1. Is It Breast Cancer or Not?
  2. The Truth About Bras and Breast Cancer Risk
  3. Guide to Skin Cancer
  4. Bottom Line Guide to Prostate Cancer

What to do: Ask your doctor if you need an esophagogastroduodenoscopy (EGD), in which an endoscope is used to explore your esophagus, stomach and duodenum (the first section of the small intestine). A biopsy can be taken during the procedure if there is suspicious-looking tissue.

ITCHING AFTER A HOT SHOWER

Most likely cause: Dry skin or a contact allergy to a cleansing product.
But it could be a sign of: Polycythemia vera, a common myeloproliferative disorder, a type of blood cancer. In the early stages of this cancer, histamine-containing mast cells (cells behind allergic reactions) become hypersensitive, causing the skin to react to hot water.
What to do: If you’re over age 40 (when this cancer most commonly occurs), ask your doctor for a complete blood count (CBC), which will detect an elevation of red blood cells, a feature of polycythemia vera.

EATING ICE

Likely cause: Iron deficiency.
But it could be a sign of: Gastrointestinal cancers, bladder cancer or any cancer that leads to blood loss. Called pica, this phenomenon—a compulsion to eat ice, sand, soil, clay, paper or chalk or to chew on something metallic—usually occurs during pregnancy and can be a sign of iron deficiency. But iron deficiency also can signal chronic internal blood loss, sometimes from cancer.
What to do: Ask your doctor about a blood test for iron deficiency. If you have an iron deficiency, work with your doctor to determine the cause.

UNBEARABLE PAIN IN A BONE WHEN TOUCHED

Most likely causes: Trauma, rheumatological disease or infection.
But it could be a sign of: Bone metastases (the spread of an original, primary tumor into the bone). This symptom is a hallmark of bone cancer.
What to do: If you have unexplained pain that tends to increase over a month—particularly if it’s sensitive to the touch—talk to your doctor about ­imaging studies, such as a CT scan, a bone scan, an X-ray or an MRI.

DIARRHEA PLUS FACIAL FLUSHING

Likely cause: Irritable bowel syndrome (IBS).
But it could be a sign of: Neuro-endocrine tumor, metastasized to the liver. Diarrhea alone rarely leads to a diagnosis of cancer, but diarrhea and flushing of the face are a unique pair of symptoms that could indicate a ­neuroendocrine tumor—a type of cancer arising from the hormone-­producing cells in the body.
What to do: Talk to your doctor about possible imaging (CT, PET or MRI) to potentially detect liver metastases and primary tumor.

REDDENED SKIN ON THE BREAST

Likely cause: Skin infection.
But it could be a sign of: Breast cancer. A lump is not the only warning sign of breast cancer. Redness of the breast—particularly if the skin also is thickened, with the texture of an orange peel—is a sign of inflammatory breast cancer, a rare and aggressive form of the disease that can be missed by a mammogram, an ultrasound or an MRI.
What to do: Ask your doctor about a breast biopsy, the best way to detect this type of cancer.Important: If the doctor diagnoses the redness as an infection and treats it with antibiotics, and the redness doesn’t resolve or worsens, return quickly for a follow-up examination.

BLOOD CLOT

Likely causes: Leg or arm injury, such as a sprained ankle…recent hospitalization or surgery…a long period of inactivity, such as a plane ride.
But it could be a sign of: Breast, pancreatic, ovarian and many other cancers. A blood clot (a symptom of deep vein thrombosis, or DVT) is a common ­problem, affecting 900,000 Americans yearly. But DVT is not commonly understood as a potential early warning sign of cancer and so is often overlooked as a cancer symptom, even though as many as one in 10 patients with an unexplained blood clot may have some type of cancer.
What to do: If you have a blood clot (typically signaled by a sudden, painful swelling of an arm or a leg) without any of the common triggers (see common causes above), talk to your doctor about a workup for cancer. This is an early warning sign that often is missed.

BLOATING

Likely cause: Eating too much or too fast.
But it could be a sign of: Ovarian cancer. Bloating is a common symptom that is rarely a sign of cancer. But persistent bloating can be a sign of cancer in the peritoneal cavity, a common feature of advanced ovarian cancer, particularly if accompanied by a persistent, dull ache in the abdomen and unexplained weight loss (a symptom of advanced cancer).
What to do: Your doctor may recommend a CT scan or a transvaginal ultra­sound. If the results are negative, ask about getting a laparoscopy, in which a thin, lighted tube is put through an incision in the belly to look at the abdominal and reproductive organs. A CT scan or a transvaginal ultrasound can easily miss ovarian cancer.

QUITTING SMOKING EASILY

Likely cause: You decided to quit, and you succeeded.
But it could be a sign of: Lung cancer. A chronic smoker who suddenly finds it unusually easy to quit may be experiencing a strange physiological symptom of lung cancer—­inexplicably losing the desire to smoke. Usually, non-small-cell lung cancer is diagnosed three to four years after a chronic smoker easily quits, and small-cell lung cancer (a more aggressive type) is diagnosed about six months after quitting.
What to do: If you have been a lifelong smoker who suddenly finds it easy to quit, talk to your doctor about having a chest CT scan for lung cancer. You also would benefit from routine annual surveillance even if the scan is negative.
http://bottomlinepersonal.com/itching-after-a-shower-and-other-surprising-cancer-symptoms/

This post is on Healthwise

Go to Healthwise for more articles

Healthwise: Posted by Healthticket at 12:00:00 am
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Labels: Blood Clots, Bottom Line, Cancer, Cancer - Bone, Cancer - Breast, Cancer - Esophagal, Cancer - Lung, Cancer Detection, Heartburn, Iron, Itch, Smoking
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TRANSLATE THE BLOG

Click the link below to translate this blog into the language of your choice: Chinese (S) Chinese (T) French German Italian Spanish Swedish Select

e-BOOKS

1. Alive and Well - Dr P Binzel
2. Diet and Health: Implications for Reducing Chronic Disease Risk


To Watch (Videos):

1. How to Have an Extraordinary Life (5:33)
2. Alternative Cancer Treatment - Dr N Gonzalez interview (1:42:22)
3. Cancer - The Forbidden Cures - Caisse, Hoxsey, Gerson
4. Angiogenesis & Cancer - Dr William Li's 2010 TED talk (20:02)
5. New breast imaging system hailed as "breakthrough" (2:50)
6. Steve Jobs' 2005 Stanford University Address (Video 15:05) (and Eulogy)
7. Human Body Maps in 3D
8. Food That Kills - MUST WATCH
9. Marketing Milk & Disease: MUST WATCH

Watch to Unwind (Videos)

1. How the English Language was Developed (11:30)
2.
World's Biggest Miniature Airport (5:25)
3. World's Largest Model Railroad (4:55)
4. George Paul Ringo 1995 One Last Time (3:31)
5. Carl Perkins, George Harrison, Ringo, Eric Clapton (10:59)
6.
Smokie - Various Videos
7. FRANCO CORELLI Nessun dorma 1961 62 (3:20)
8. Andrea Borcelli - Various Videos
9. Michael Buble & Blake Shelton duet (4:53)
10. Ferrari Shell Commercial (1:55)
11. Two Dogs Dining - You Will Love This Video!
12. Tribute to Whitney Houston - Various Videos
13. Adele - Rolling In The Deep Video
14. Concorde - 27 Years of Supersonic Flight (3:04:48)
15. Tribute To Robin Gibb
16. Randy Travis - Forever and Ever, Amen
17. Neil Young - Heart of Gold, etc
18. Roy Orbison Black & White Night - MUST WATCH!
19. Airbus A380 - Giant Of The Skies - Videos
20. Ultimate Factories "Lamborghini" - Video
21. Nat Geo Bugatti Veyron (Video 45:05)
22. Melody Fair - The Movie - Music by The Bee Gees
23. Here Comes the Sun: A Tribute to George Harrison b...
24. Rod Stewart & Amy Belle - I Dont Want To Talk Abou...
25. Joe Cocker - Into The Mystic

MUST READS:-

1. Healing Illness - A Natural Anti-Cancer Protocol
2. Natural Options for Cancer Treatment
3. Sugar and Cancer Cell Growth
4. Turmeric - Super Spice to Combat Cancer, Arthritis, and Alzhemer's
5. Top Five Breakthroughs of the Decade
6. Honey and Cinnamon
7. Foods that weaken your bones
8. A Study on Vitamins and Supplements
9. Edible Healing: Food Cures for Cancer
10. The Health Dangers of Soy
11. 11 Changes to Prevent Cancer
12. 7 All-Natural Ways to Activate your Body's Healing Force
13. Medical Breakthrough Cancer Cure?
14. Chlorella - the Way to Detoxify yr Liver
15. Vitamin B17 Kills Cancer Cells
16. GMO Food Dangers
17. Check Your Thyroid Function
18. Natto - Health Benefits of Super Food
19. Why Drinking Alcohol Makes You Fat
20. Two Foods You Should Never, Ever Eat After Exercise
21. 7 Easy Ways to Detox Your Way To More Energy
22. Debunking the Cholesterol Myth
23. The Best Natural Anti-Inflammatories
24. New Studies on 3 Important Nutrients
25. Natural Cancer Prevention Strategies
26. Sugar and Alcohol - the Similarities
27. Is Sugar Toxic? The Bitter Truth
28. Sugar and Cancer Cell Growth
29. Top 10 Markers for Heart Disease
30. Five Warning Signs of Heart Problems
31. Natto Benefits Create Long Healthy Lives ...
32. Complementary Cancer Therapies: A Guide for Patients and Survivors
33. 10 Easy Ways to Prevent Cancer at Home - Dr Mercola
34. 11 Top Changes You Can Make to Prevent Cancer
35. Understanding the Liver and Cholesterol

For Reference

1. A Closer Look at Cholesterol Numbers 2. Blood Tests-Types Results & Meaning 3. BBC Cancer Resource 4. What's the Best Time to Take Your Pills? 5. MedHelp.org - The World's Largest Health Community 6. Tumor Markers 7. BLOOD TEST NORMAL VALUES 8. Top 10 Markers for Heart Disease

Please note :-

The contents of this personal blog are compiled from public media and emails I received. They are therefore the opinions of the respective writers and publications. The purpose of this blog is for education and sharing of knowledge. The source of the article is quoted where available.

The information presented here is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis.

Please make your own health care decisions based upon your research and in consultation with a qualified health care professional regarding your own personal medical circumstance.

If you have any articles which you wish to share on this blog, please send the link to healthticket@gmail.com

If you like this blog, please bookmark it and tell your friends. In the meantime, I wish you happy reading, and be good, Healthwise!

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The information presented here is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis.

Please make your own health care decisions based upon your research and in consultation with a qualified health care professional regarding your own personal medical circumstance.

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