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Showing posts with label Iron. Show all posts
Showing posts with label Iron. Show all posts

Wednesday, 5 October 2022

Cabbage: Experts weigh in on health benefits, nutrition facts, and more

Cabbage is packed in nutrients as vitamins, fibers and minerals and also in micronutrients too as vitamin A, iron and riboflavin.

Leticia Soares, Postgraduate Degree in Public and Family Health/Bachelor Degree in
Nutrition and Dietetics and Carolina Castro, PhD Candidate (Health Services) -


Wednesday 05 Oct 2022

https://www.msn.com/en-my/health/nutrition/cabbage-experts-weigh-in-on-health-benefits-nutrition-facts-and-more/ar-AA12Assi


Cabbage image© Provided by Getty Images

Perspective from Leticia Soares

Benefits

  • Cabbage can help control high blood pressure. Cabbage is a source of fiber, folic acid and potassium. Potassium relaxes the walls of the blood vessels, lowering blood pressure and protecting cardiovascular system.
  • Cabbage may help in weight loss. The vegetable has few calories and it is rich in dietary fiber, which promotes the feeling of satiety for a longer time, helping in weight loss.
  • Cabbage regular consumption contributes to a healthy vision. Cabbage is rich in vitamin A, which is one of the most important nutrients to reduce the risk of macular degeneration and vision loss.
  • Cabbage can strengthen the immune system. Cabbage is a source of antioxidants compounds such as vitamin C, carotenoids and folate, which help prevent that free radical damage body cells and protect the body against infection.
  • Cabbage help prevent constipation. The high dietary fiber content of cabbage can help make your stools larger and softer and this can help lower the risk of constipation and diarrhea.
  • Cabbage has anti-inflammatory properties. The vegetable is a source of antioxidants that fight inflammation and prevent chronic diseases such as type 2 diabetes, heart disease, Alzheimer, cancer and depression.
  • Possible Side Effects

    • Excess consumption of cabbage can lead to increased gas, as it is high in sulphur and raffinose, which are substances that cause flatulence and gas.

    → Cabbage: How much should you eat? Experts weigh in.

    → Love Cabbage? Get nutritional facts, tips from health experts, and more

    Perspective from Carolina Castro

    Benefits

    • Cabbage is packed in nutrients as vitamins, fibers and minerals and also in micronutrients too as vitamin A, iron and riboflavin.
    • Cruciferous vegetables as cabbage are rich in antioxidants and may help avoid inflammation.
    • Cabbage has insoluble fibers, may improve digestive health and also feeds good bacteria known as probiotics.
    • Cabbage is rich in pigments as anthocyanins and may have a protection effects in heart diseases.

    Possible Side Effects

    • Cabbage as a cruciferous vegetable can have medication interactions with blood thinners.
    • Excess of cabbage may also cause digestive symptoms as flatulence and diarrhea.

    → Cabbage: How much should you eat? Experts weigh in.

    → Love Cabbage? Get nutritional facts, tips from health experts, and more

    This is for information purpose only, and should not be considered as a substitute for medical expertise. These are opinions from an external panel of individual doctors, and not to be considered as opinion of Microsoft. Please seek professional help regarding any health conditions or concerns.

https://www.msn.com/en-my/health/nutrition/cabbage-experts-weigh-in-on-health-benefits-nutrition-facts-and-more/ar-AA12Assi


Tuesday, 3 March 2020

Coronavirus UK: Five best supplements to boost your immune system amid coronavirus fears

CORONAVIRUS fears continue to intensify against a backdrop of rising cases, school closures and cancelled flights in the UK. While there is currently no vaccination in sight, it is important to keep your immune system in fighting form. To that end, here are five supplements proven to boost your immune system.

Coronavirus cases in the UK rose to 39 yesterday, as the government outlined measures to minimise the threat to citizens, which included possible school closures, cancelling events and bringing NHS staff out of retirement. The uncertainty surrounding when there will be a vaccine understandably has people rattled, but the pattern of the virus does shed light on the nature of the threat. The most serious cases show that a weakened immune system leaves you highly susceptible to developing the respiratory infection so it is important to keep your immune system as defensive as possible.
One simple yet effective way to enhance your immune system is to take certain supplements, and, while this does not guarantee protection against the pathogen, it will at least ensure the virus comes into contact with a robust defence system.
Georgie Murphy, MSc Nutrition ANutr at nutritional website Vitl.com, recommends the following five supplements to optimise your immune system:

Vitamin C

According to Murphy, vitamin C is possibly the best thing you can consume if you’re looking to give your immune system a big boost.
She explained: “Vitamin C helps stimulate the production of white blood cells (also known as leukocytes).
“These are cells from your immune system that help to fight infectious disease and foreign invaders.
Vitamin C helps stimulate the production of white blood cells
Best supplements: Vitamin C helps stimulate the production of white blood cells (Image: Getty Images )
Murphy continued: “It’s a vital vitamin needed for repairing and growing tissue; it helps heal wounds, maintain healthy bones and acts as an antioxidant, fighting free radicals that can weaken the immune system.”
To top it up, consume foods rich in the nutrient, such as oranges, kiwifruit, brussels sprouts and potatoes on a daily basis, she said.

Zinc

“Zinc is an immunity superhero that is often overlooked when it comes to fighting colds,” explained Murphy.
She added: “It works synergistically with vitamin C, which is why we combine these nutrients in our personalised formulations if your immune system needs an extra helping hand. Studies have shown that zinc may help to reduce the duration of colds by up to 50 percent.”
Zinc can be found in a number of supplements.

Vitamin E

Similarly to vitamin C, vitamin E acts as an antioxidant that assists in fighting off infection, notes Murphy.
The vitamin can be found in numerous supplements and certain foods, such as almonds, peanuts, sunflower seeds and spinach.

Beta-Glucans

As Murphy explains, mushrooms have been touted as traditional medicine in Asia for thousands of years due to their well-known immune-boosting powers.
“As well as having antibacterial and antiviral properties, mushrooms also contain beta-glucans. Beta-glucans make up the mushroom cell walls and stimulate the immune system,” she said.
Mushrooms contain beta-glucans that stimulate the immune system
Best supplements: Mushrooms contain beta-glucans that stimulate the immune system (Image: Getty Images)

Vitamin D

Most people struggle to get enough vitamin D in the winter months, which is a problem for people’s immune systems as vitamin D stimulates the production of antimicrobial proteins, which the body relies on to fight off infection, explained Murphy.
She continues: “The reason this vitamin is so important is because it has receptors that activate enzymes on the surfaces of our white blood cells.”
As Murphy warns, not getting enough vitamin D can also lead to autoimmune diseases or repeated infection.

How to get enough vitamin D

Between October and early March people don't get enough vitamin D from sunlight so the vitamin can be found in supplements and a number of foods, including:
  • Oily fish – such as salmon, sardines, herring and mackerel
  • Red meat
  • Liver
  • Egg yolks
  • Fortified foods – such as most fat spreads and some breakfast cereals
Vitamin E acts as an antioxidant that assists in fighting off infection
Best supplements: Vitamin E acts as an antioxidant that assists in fighting off infection (Image: Getty Images)

Iron

Iron is an essential mineral that helps to transport oxygen throughout the body that is fundamental to the growth of B cells and T cells that are a major cellular components of the adaptive immune response, explained Murphy.
Consequently, low iron levels affect the body’s capacity to adequately protect the body from viruses, bacteria and other pathogens, she said.

How can you top up iron?

“You can take iron supplements if you feel you do not eat enough foods rich in the nutrient, such as tofu, beans, lentils, baked potatoes or fortified cereals,” advised Murphy.

What are the symptoms of the coronavirus?

According to the NHS, the symptoms of coronavirus are:
  • A cough
  • A high temperature
  • Shortness of breath

Friday, 21 February 2020

Iron levels in the brain and Parkinson’s disease

Scientists hope tracking iron levels in the brain could help diagnose Parkinson’s disease

Metro Science Reporter  Friday 21 Feb 2020 9:06 am

Unrecognizable teenage girl with grandmother at home, holding hands. Family and generations concept. Close up.
A build-up of dangerous proteins in the brain can cause Parkinson’s and other neurodegenerative diseases (Getty Images/iStockphoto)


A new imaging technique that tracks the accumulation of iron in the brain could be helpful for the early diagnosis of Parkinson’s and other neurodegenerative diseases, according to research. 

Scientists say they have developed a ‘cutting-edge’ method, called quantitative susceptibility mapping, to map iron levels in the brain based on scans. 

They say this technique is more advanced than conventional brain imaging, which fails to track Parkinson’s progression until late stage. Based on their findings, the researchers believe measuring iron deposits in the brain could also help predict which people with Parkinson’s will develop dementia. 

Dr Rimona Weil, of University College London’s (UCL) Queen Square Institute of Neurology and lead author on the study, said: ‘Iron in the brain is of growing interest to people researching neurodegenerative diseases such as Parkinson’s and dementias. 

‘As you get older, iron accumulates in the brain, but it’s also linked to the build-up of harmful brain proteins, so we’re starting to find evidence that it could be useful in monitoring disease progression, and potentially even in diagnostics.’ 

The researchers studied 97 people with Parkinson’s disease along with 37 people without the condition. The participants were given scores based on tests on thinking, memory and motor function. 

The researchers mapped the iron levels in the brain using their new quantitative susceptibility mapping technique. They found that iron accumulation in the hippocampus and thalamus brain regions was associated with poor memory and thinking scores, while iron in the putamen region of the brain correlated with poor movement scores. 

Substantia nigra. Computer illustration showing a degenerated substantia nigra in Parkinson's disease. The substantia nigra plays an important role in reward, addiction, and movement. Degeneration of this structure is characteristic of Parkinson's disease. In Parkinson's neurons in the substantia nigra contain Lewy bodies, which are deposits of protein, shown here as small red spherical inclusions in the neuron's cytoplasm.
Computer illustration showing a degenerated substantia nigra in Parkinson’s disease. The substantia nigra plays an important role in reward, addiction, and movement. Degeneration of this structure is characteristic of Parkinson\’s disease. (Getty Images/Science Photo Library)

Based on their findings, the researchers said it is ‘very promising that iron deposition was specifically detected in those areas’. 

They believe tracking iron deposits in the brain could help clinicians determine whether a treatment is working or not and could, in future, be helpful for early diagnosis of Parkinson’s or other neurodegenerative diseases. 

Co-author Dr Julio Acosta-Cabronero, of the UCL’s Wellcome Centre for Human Neuroimaging, said: ‘We hope that brain iron measurement could be useful for a wide range of conditions, such as to gauge dementia severity or to see which brain regions are affected by other movement, neuromuscular and neuroinflammatory disorders, stroke, traumatic brain injury and drug abuse.’ 

Professor David Dexter, Deputy Director of Research at Parkinson’s UK, said: ‘Frustratingly, we are currently unable to catch Parkinson’s in its early stages, which creates a huge barrier to finding treatments that can stop, slow or reverse the condition. 

‘We know that people with Parkinson’s have a higher-than-average risk of developing dementia, so the exciting use of the MRI scan to potentially identify Parkinson’s earlier, as well as helping to predict which people with Parkinson’s will develop dementia, opens up a new avenue for research to explore. 

‘The findings also suggest that using brain scans to measure levels of iron in the brain could be valuable to track if a treatment is working in a clinical trial, which could lead to better treatments faster for the 145,000 people living with Parkinson’s in the UK.’ 

The researchers are following up the same study participants to see how their disease is progressing while monitoring the changes in their brain’s iron levels. The research is published in the Journal of Neurology, Neurosurgery, and Psychiatry.


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Friday, 7 February 2020

Plant-Based Diet: Everything You Need To Know

On the surface, a plant-based diet sounds simple. And although it’s been trending lately, the idea of eating “mostly plants” has been in the zeitgeist since Michael Pollan spelled it out in “The Omnivore’s Dilemma” in 2006.
06 Feb 2020

Christine Byrne

That said, anyone who has been given a plant-based diet prescription from their doctor, or tried to move away from the “standard American diet” and toward a more plant-based one, knows that doing so isn’t quite as simple as it sounds.

A strict plant-based diet means eating no animal products (aka veganism), but not everything is black and white.

Obviously, a plant-based diet centers on plants: fruits, veggies, whole grains, nuts, seeds, beans and legumes. Strictly speaking, it excludes all animal products, including not only meat but eggs and dairy. Some people follow a more flexible plant-based diet that includes a little bit of meat and/or dairy, which isn’t technically a plant-based diet. But since both strict plant-based diets and more flexible ones are valid choices with proven health benefits, we’ll talk about both of them here. 
“Some people say plant-based and mean vegan while others don’t,” said Marisa Moore, a registered dietitian based in Atlanta. “I use the term to mean mostly plants, not vegan.”
Then, there’s the question of what kind of plant-based food should be included in the diet. “Another group takes plant-based to mean 100% ‘whole foods’ plant-based, meaning even processed foods that are made entirely of plants are excluded,” said Taylor Wolfram, a registered dietitian based in Chicago. She also pointed out that there is “no standard definition of processed food,” which further muddies the idea of what a “whole foods” plant-based diet really is.
A plant-based diet centers around plants: fruits, veggies, whole grains, nuts, seeds, beans and legumes. Strictly speaking, it excludes all animal products.© bauhaus1000 via Getty Images A plant-based diet centers around plants: fruits, veggies, whole grains, nuts, seeds, beans and legumes. Strictly speaking, it excludes all animal products.
The bottom line is: One person’s plant-based diet might exclude animal products and processed foods, while another person’s might make a little bit of room for these things. What all plant-based diets have in common is that they emphasize eating mostly minimally processed plant foods. 

There’s evidence that eating a more “whole foods” plant-based diet can improve health, even if you don’t cut out animal products completely.

Good news for anyone who can’t fathom giving up cheese or steak forever: You don’t need to eat 100% plant-based to see health benefits. Shivam Joshi is an internal medicine physician at the New York University School of Medicine who eats an entirely plant-based diet, but he doesn’t necessarily recommend that to his patients.
Many of them are immediately turned off by the idea of going completely vegetarian or vegan. “I don’t tell people to go vegetarian or vegan,” Joshi said. Instead, he tells them to eat plant-based meals most of the time, without worrying about cutting out meat and dairy altogether.
“You can get most of the benefits of a full-on plant-based diet by eating this way. No one has really shown that full-on vegan is better,” he said. 
Moore also pointed out that eating a mostly plant-based diet “leaves room for flexibility, which can remove a lot of stress around eating. I’m a big fan of flexibility when it comes to food ― no need to try to be perfect.”
Moore suggested a limited amount of flexibility, though: “If you’re newly transitioning to a plant-based diet, you might start by adding just one or two plant-based meals per week and gradually work your way down.” Or, you could make a goal to only eat meat X times per week, depending on what feels realistic for you. 
Joshi emphasized a diet rich in unprocessed, high-fiber plant foods. In the short run, he said, these foods deliver high levels of vitamins and minerals, and can help lower cholesterol and blood sugar levels. In the long run, these effects can improve a person’s health outcomes. 
“Epidemiological data shows that the more plant foods someone eats, the lower their risk for certain chronic diseases, including cardiovascular disease, Type 2 diabetes and some cancers,” Wolfram said. 

OK, but what does shifting to a plant-based diet actually look like?

“Whenever someone is considering a plant-based diet, I generally suggest starting off slow,” said Ryan Maciel, a registered dietitian with Precision Nutrition. “Start with one of your favorite dishes ― let’s say a chicken stir-fry. Replace the chicken with beans, lentils or tofu as your plant-based protein source.” In other words, take some time to get comfortable with cooking and eating a few simple plant-based meals before you start overhauling your entire diet.
a close up of a flower: One person’s plant-based diet might exclude animal products and processed foods, while another person’s might make a little bit of room for these things. What all plant-based diets have in common is that they emphasize eating mostly minimally processed plant foods.© Nastasic via Getty Images One person’s plant-based diet might exclude animal products and processed foods, while another person’s might make a little bit of room for these things. What all plant-based diets have in common is that they emphasize eating mostly minimally processed plant foods.
You can also focus on upping your fruit and vegetable intake before making any other major changes. Joshi pointed out that only 1 in 10 Americans eats the recommended five servings per day, and that making this a priority will have a huge impact ― you’ll get more vitamins, minerals and fiber, and likely eat less saturated fat (which the U.S. Department of Agriculture recommends limiting to 10% of your total calories in order to lower your risk of heart disease). And, you’ll get the most out of those five-a-day if you eat a variety, including leafy greens every day, because you’ll also get a variety of nutrients. 

When and if you do start eating primarily plant-based foods, be sure to prioritize protein and other key nutrients that are less abundant in plant foods. 

Wolfram emphasized the importance of prioritizing protein-rich plant foods.
“Legumes are a key food group for plant-based eaters to meet protein and amino acid recommendation,” she said. Protein recommendations vary from person to person, but the National Academy of Medicine recommends that adults get 0.8 grams of protein per kilogram of body weight each day, about 50 grams per day for a 140-pound person.
“Legumes include beans, lentils, peas, peanuts and soy foods such as tofu and tempeh. Plant-based eaters should strive for a minimum of 3 to 4 servings of these foods every day (1/2 cup beans, lentils, peas and soy foods; 1/4 cup peanuts; 2 tablespoons peanut butter).”
Maciel emphasized the importance of getting adequate micronutrients. Here are some ways to do that:
  • Dark leafy greens, beans and fortified grains are a good source of iron, and eating them alongside foods rich in vitamin C (like citrus and bell peppers) can help with iron absorption. 
  • Omega 3-fatty acids are essential fats that can improve your health by reducing your risk of heart disease,” Maciel said. Omnivores can get these from fatty fish, but walnuts, flaxseeds and chia seeds are all good plant-based sources.
  • Dairy is off-limits, but it’s a major source of calcium. “There are plenty of other options for you to choose to meet your needs,” Maciel said. Fortified plant-based milks, tofu, broccoli, leafy greens, beans, nuts and seeds are all good sources.
  • “It can be challenging to get enough vitamin D from whole food sources, especially for vegetarians,” Maciel said. Although things like plant-based milk, orange juice and cereals are often fortified, people who don’t get much sun exposure might be lacking in vitamin D ― talk to your doctor about possible supplementation.
  • Iodine is needed to make thyroid hormones,” Maciel said. “Since iodine is naturally found in foods such as fish and dairy, plant-based eaters excluding these foods may be at risk.” Seaweed and fortified grains are good sources, or you could switch to using iodized salt (many salts at the grocery store are iodized). 
  • “Vitamin B12 is only found in animal products and fortified foods,” Maciel said. “Therefore, vegans need to take a B12 supplement or consume foods fortified with vitamin B12. Plant-based options include fortified plant-based milks, fortified cereals and fortified nutritional yeast.”

On a plant-based diet, your “staples” will look a little bit different. 

“Especially if this is a new way of eating, know that it may take some time to figure it all out,” Moore said. “You’ll need to plan a little more to make sure you’re getting the nutrition you need and not going hungry because you’re not sure what you can eat.” Cooking big batches of veggies and grains at the start of each week can make things easier, as can keeping plenty of canned or dried beans, nuts and seeds on hand. 
Although processed foods shouldn’t make up the bulk of your plant-based diet, store-bought frozen veggie burgers and other plant-based meat alternatives are a smart way to round out your meals when you’re pressed for time and/or staring down an empty fridge. Likewise, fortified cereals and breads are good sources of many of the nutrients that Maciel mentioned above, so look for whole-grain versions and make them a staple in your kitchen.

One final thing to keep in mind: A plant-based diet isn’t realistic for everyone, and that’s OK.

What many plant-based diet advocates forget is that not everyone has access to unprocessed plant-based foods, and that even those who do might not realistically be able to eat them regularly. Roughly 11% of the U.S. population is food-insecure, meaning they don’t consistently have access to fresh and healthy foods. For anyone in this position, a plant-based diet will be nearly impossible. And even individuals who can access whole foods might not have time to prepare them regularly ― cooking whole foods from scratch takes longer than picking up ready-made food or cooking convenience foods. This is important to keep in mind when deciding whether a plant-based diet is realistic for you ― it’s also a reason not to extol the virtues of such a diet to everyone you meet, as it might instill shame in someone who just can’t eat that way.
“Plant-based diets can be appealing to those with eating disorders and disordered eating because certain foods are restricted and, therefore, the diet can reduce calories,” Maciel said. “For these individuals, a plant-based diet or any diet that restricts certain foods probably isn’t the best idea.” Instead, he recommended that those individuals shift away from food rules, with the help of a registered dietitian or therapist, if possible.
And of course, remember that how you eat is ultimately up to you. “If someone has no interest in eating plant-based, then it isn’t something they should force,” Wolfram said. Eating one way or another doesn’t make you morally superior to anyone, and no one way of eating can guarantee health (or, just as importantly, happiness). Also, remember that the way you choose to eat might evolve over time, and there’s no need to put a label on your diet ― if eating an entirely or mostly plant-based diet seems like a good idea for you right now, for health reasons or other reasons, do it! But if your priorities shift in the future, it’s OK that your eating habits do, too.
This article originally appeared on HuffPost.

https://www.msn.com/en-my/health/nutrition/plant-based-diet-everything-you-need-to-know/ar-BBZH8M6?ocid=ientp

Wednesday, 9 October 2019

Iron Tests

Iron tests evaluate the amount of iron in the body by measuring several substances in the blood.

This article was last reviewed on

This article waslast modified on September 23, 2019.

Why Get Tested?
To evaluate your body's current level of iron; to help diagnose iron deficiency or iron overload
When To Get Tested?
When you have low hemoglobin and hematocrit on a complete blood count (CBC); when your healthcare practitioner suspects that you may have too little iron (deficiency) or too much iron (overload) in your body
Sample Required?
A blood sample drawn from a vein in your arm
Test Preparation Needed?
You may be instructed to have your blood drawn in the morning and/or fast for 12 hours before the test; in this case, only water is allowed. Follow any instructions from your healthcare practitioner and/or from the laboratory performing the test.
What is being tested?
Iron is an essential nutrient that, among other functions, is needed in small quantities to help form normal red blood cells (RBCs). It is a critical part of hemoglobin, the protein in RBCs that binds oxygen in the lungs and releases it as blood circulates to other parts of the body. The body cannot produce iron and must absorb it from the foods we eat or from supplements.
Iron tests evaluate the amount of iron in the body by measuring several substances in the blood. These tests are often ordered at the same time and the results interpreted together to help diagnose and/or monitor iron deficiency or iron overload.
  • Serum iron test—measures the level of iron in the liquid portion of the blood.
  • Transferrin test—directly measures the level of transferrin in the blood. Transferrin is the protein that transports iron around in the body. Under normal conditions, transferrin is typically one-third saturated with iron. This means that about two-thirds of its capacity is held in reserve.
  • TIBC (total iron-binding capacity)—measures the total amount of iron that can be bound by proteins in the blood. Since transferrin is the primary iron-binding protein, the TIBC test is a good indirect measurement of transferrin availability.
  • UIBC (unsaturated iron-binding capacity)—The UIBC test determines the reserve capacity of transferrin, i.e., the portion of transferrin that has not yet been saturated with iron. UIBC also reflects transferrin levels.
  • Transferrin saturation—a calculation that reflects the percentage of transferrin that is saturated with iron (100 x serum iron/TIBC).
  • Serum ferritin—reflects the amount of stored iron in the body.
Iron is normally absorbed from food in the small intestine and transported throughout the body by binding to transferrin, a protein produced by the liver. In healthy people, most of the iron transported is incorporated into the production of red blood cell hemoglobin. The remainder is stored in the tissues as ferritin or hemosiderin, with additional small amounts used to produce other proteins such as myoglobin and some enzymes.
When the level of iron is insufficient to meet the body's needs, the level of iron in the blood drops and iron stores are depleted. This may occur because:
  • There is an increased need for iron, for example during pregnancy or childhood, or due to a condition that causes chronic blood loss (e.g., peptic ulcercolon cancer)
  • Not enough iron is consumed (either foods or supplements)
  • The body is unable to absorb iron from the foods eaten in conditions such as celiac disease
Insufficient levels of circulating and stored iron may eventually lead to iron-deficiency anemia (decreased hemoglobin and hematocrit, smaller and paler red cells). In the early stage of iron deficiency, no physical effects are usually seen and the amount of iron stored may be significantly depleted before any signs or symptoms of iron deficiency develop. If a person is otherwise healthy and anemia develops over a long period of time, symptoms seldom appear before the hemoglobin in the blood drops below the lower limit of normal.
However, as the iron deficiency progresses, symptoms eventually begin to appear. The most common symptoms of anemia include fatigue, weakness, dizziness, headaches and pale skin. Read the article on Anemia to learn more.
Conversely, too much iron can be toxic to the body. Iron storage and ferritin levels increase when more iron is absorbed than the body needs. Absorbing too much iron over time can lead to the progressive buildup of iron compounds in organs and may eventually cause their dysfunction and failure. An example of this is hemochromatosis, a rare genetic disease in which the body absorbs and builds up too much iron, even on a normal diet. Additionally, iron overdose can occur when someone consumes more than the recommended amount of iron.
Common Questions
  • How is it used?

    Iron tests are used to assess the amount of iron circulating in the blood, the total capacity of the blood to transport iron, and the amount of stored iron in the body. Testing may also help differentiate various causes of anemia.
    Iron tests are often ordered together, and the results of each can help identify iron deficiency, iron deficiency anemia, or too much iron in the body (overload).
When is it ordered?


Iron tests may be ordered when results from a routine complete blood count (CBC) show that a person's hemoglobin and hematocrit are low and their red blood cells are smaller and paler than normal (microcytic and hypochromic), suggesting iron deficiency anemia even though other clinical symptoms may not have developed yet.
Iron tests may be ordered when a person develops signs and symptoms of anemia, such as:
  • Chronic fatigue/tiredness
  • Dizziness
  • Weakness
  • Headaches
  • Pale skin (pallor)
Iron tests may be ordered when iron overload is suspected. Signs and symptoms of iron overload will vary from person to person and tend to worsen over time. They are due to iron accumulation in the blood and tissues. These may include:
  • Joint pain
  • Fatigue, weakness
  • Lack of energy
  • Abdominal pain
  • Loss of sex drive
  • Organ damage, such as in the heart and/or liver
When a child is suspected to have ingested an excessive amount of iron tablets, a serum iron test is ordered to detect and help assess the severity of the poisoning.
What does the test result mean?


A summary of the changes in iron tests seen in various diseases of iron status is shown in the table below.
DiseaseIronTIBC/Trans
ferrin
UIBC% Transferrin
Saturation
Ferritin
Iron DeficiencyLowHighHighLowLow
Hemochroma
tosis
/
Hemosiderosis
HighLowLowHighHigh
Chronic IllnessLowLow/NormalLow/
Normal
Low/NormalNormal/
High
Hemolytic
Anemia
HighNormal/LowLow/
Normal
HighHigh
Sideroblastic
Anemia
Normal/
High
Normal/LowLow/
Normal
HighHigh
Iron PoisoningHighNormalLowHighNormal

Iron deficiency
The early stage of iron deficiency is the slow depletion of iron stores. This means there is still enough iron to make red cells, but the stores are being used up without adequate replacement. The serum iron level may be normal in this stage, but the ferritin level will be low.
As iron deficiency continues, all the stored iron is used and the body tries to compensate by producing more transferrin to increase iron transport. The serum iron level continues to decrease and transferrin and TIBC and UIBC increase. As this stage progresses, fewer and smaller red blood cells are produced, eventually resulting in iron deficiency anemia.
Iron overload
If the iron level is high, the TIBC, UIBC and ferritin are normal and the person has a clinical history consistent with iron overdose, then it is likely that the person has iron poisoning. Iron poisoning occurs when a large dose of iron is taken all at once or over a short period of time. Iron poisoning in children is almost always acute, occurring in children who ingest their parents' iron supplements. In some cases, acute iron poisoning can be fatal.
A person who has mutations in the HFE gene is diagnosed with hereditary hemochromatosis. However, while many people who have hemochromatosis will have no symptoms for their entire life, others will start to develop symptoms such as joint pain, abdominal pain, and weakness in their 30's or 40's. Men are affected more often than women because women lose blood during their reproductive years through menstruation.
Iron overload may also occur in people who have hemosiderosis and in those who have had repeated transfusions. This may occur with sickle cell anemiathalassemia major, or other forms of anemia. The iron from each transfused unit of blood stays in the body, eventually causing a large buildup in the tissues. Some people with alcoholism and with chronic liver disease also develop iron overload.
Is there anything else I should know?


Recent consumption of iron-rich foods or iron supplements can affect test results, as can recent blood transfusions.
Normal iron levels are maintained by a balance between the amount of iron taken into the body and the amount of iron lost. Normally, a small amount of iron is lost each day, so if too little iron is taken in, a deficiency will eventually develop. Unless a person has a poor diet, there is usually enough iron to prevent iron deficiency and/or iron deficiency anemia in healthy people.
In certain situations, there is an increased need for iron. Persons with chronic bleeding from the digestive tract (usually from ulcers or tumors such as colorectal cancer) or women with heavy menstrual periods will lose more iron than normal and can develop iron deficiency. Women who are pregnant or breast feeding lose iron to their baby and can develop iron deficiency if not enough extra iron is taken in. Children, especially during times of rapid growth, may need extra iron and can develop iron deficiency. Iron deficiency can also be seen in malabsorption diseases such as celiac disease.
Low serum iron can also occur in states where the body cannot mobilize and use storage iron properly. In many chronic inflammatory conditions, especially in cancers, autoimmune diseases, and with chronic inflammations or chronic infections (including AIDS), the body cannot properly use iron to make more red cells. Under these conditions, production of transferrin decreases, and serum iron is low because little iron is being absorbed from the gut and storage iron can't get mobilized, and ferritin increases.
Do all people with iron deficiency have anemia? What are the symptoms?


Iron deficiency refers to a decrease in the amount of iron stored in the body, while iron deficiency anemia refers to a drop in the number of red blood cells (RBCs)hemoglobin and hematocrit caused by not having enough stored iron (there are many other causes of anemia). It typically takes several weeks after iron stores are depleted for the level of hemoglobin and production of RBCs to be affected and for anemia to develop. There usually are few symptoms early in iron deficiency, but as the condition worsens and blood levels of hemoglobin and RBCs decrease, then ongoing weakness and fatigue can eventually develop.
As your iron continues to be depleted, you may have shortness of breath and dizziness. If the anemia is severe, chest pain, headaches, and leg pains may occur. Children may develop learning (cognitive) disabilities. Besides the general symptoms of anemia, there are certain symptoms that are characteristic of iron deficiency. These include dysphagia, pica (cravings for specific substances, such as ice, corn starch, licorice, chalk, dirt, or clay), a burning sensation in the tongue or a smooth tongue, sores at the corners of the mouth, and spoon-shaped fingernails and toenails.

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See also:  MUST READ - Check Your Iron Level, Not Your Cholesterol