Pages

Showing posts with label Bone health. Show all posts
Showing posts with label Bone health. Show all posts

Tuesday, 5 December 2017

Curious Cook: Vegetarianism and other dietary tales, Part 3

This issue explores the almost existential question of why we eat, and why milk is essential to infants but bad news for adults; lacto-vegetarians, take note.


Before continuing with the discussion about vegetarianism or other dietary choices, a couple of questions should first be asked. One is: Why do we eat? If that sounds a little silly and rhetorical, then try another question: Why do humans have the longest childhood of all known animals, requiring around 20 years before full maturity? No other creature needs such a long time to mature – even whales are considered mature between seven to 10 years of age.
The answers to both questions are related, and complex – and they start with human breast milk.

A little story about human oligosaccharides

Around the end of the 19th century, researchers noted that human infants fed with their mother’s milk had a higher survival rate compared to infants fed on cow or goat milk.
Then around the 1930s a mysterious, indigestible compound called “gynolactose” was discovered in human mammary milk. Later it turned out that gynolactose was actually a collection of over a hundred different complex sugars called human milk oligosaccharides (HMO), and HMO was the third most common component in human milk, after lactose and fat.

milk
Apart from humans, no other species on Earth constantly consumes the milk of another species. — Photo: Fotolia/TNS
However, it was deeply puzzling as to why human mothers expend so much energy to produce oligosaccharides which are indigestible by their infants.
It was in 1954 that the Austrian chemist Kuhn and the American-Hungarian paediatrician Gyorgy discovered that HMO was actually used to nourish gut microbes in infants, specifically an unusual strain with a digestive cluster made up of 30 genes called Bifidobacterium longum infantis (or B. infantis for short).
It appears that B. infantis converts HMO into short chain fatty acids which actively feeds the gut cells of infants, promoting the production of adhesive proteins which help seal the gut from the bloodstream (thereby reducing microbial infections) – and it also produces anti-inflammatory molecules for use by the infant immune system.
There are other interesting and more fanciful theories about the benefits of HMO to human infants which are also not discounted – but the salient fact is that evolution has determined that human mothers produce HMO to protect and develop the guts of infants.
For modern humans, the brain is considered the most important organ for survival – humans actually have no particular attributes which are outstanding in the physical world (apart perhaps from the ability of our opposing thumbs to handle tools effectively).
HMO is a clear indication of the importance of the human gut – and the relationship between the intestines and the developing brains of young humans is a major factor why humans take so long to mature.
Young humans actually do grow at quite a fast rate, though not nearly as fast as most other animals and a reason is that young humans have to balance the development of the brain with the physical development of the body.
Brains are extremely demanding in terms of energy for young humans, requiring around 40% of the energy intake from food compared to only about 20% for adults – other primates use roughly only 8% of their energy for their brains.
This is why young people tend to eat a lot (and not get fat) as the energy cost of growing and developing the synaptic connections in the brain is roughly double the energy of just using the brain.
At the same time, young humans have to develop other organs and skeletal structures as well – and therefore it is necessary to extract as much nutrients as possible from food via the intestines. These nutrients are not just calories but also essential minerals and other compounds such as fats, vitamins, antioxidants, et cetera.
As such, it is biologically very important for humans to maintain healthy intestines from birth – human guts are necessary to extract the huge amount of energy and nutrition needed over a long period of time (around 20 years) to fully develop the brain and the rest of the body.
The length of the intestinal system is also relatively longer in young humans, presumably to be more efficient at extracting nutrients.

eating
We need food so that our bodies do not run short of fuel and die. Photo: AFP

And now, why we eat

The simpler question as to why we eat actually has two answers. The obvious one is that we need energy from food to breathe, think, move, maintain internal organs and disease defences, et cetera.
In short, we need food so that our bodies do not run short of fuel and die.
However, even after our bodies have matured after the initial 20 years or so, the fact is we are still growing – or rather, we are recycling and replenishing our bodies all the time regardless of age.
For example, the human skin is constantly flaking off and renewing itself, and a human adult in good health will attain a new layer of skin every 30 days or so. Adult taste buds are renewed every two weeks, red blood cells every four months – even the liver is regenerated every year, and so on.
The only organs which do not regenerate are the central nervous system (including the brain), the lenses in the eyes and the ovaries of women.
All this rejuvenation again depends on the efficient extraction of energy and nutrients by our intestinal system, which was kick-started by HMO. At this point, it is important to note that as humans get older, the intestinal microbiota tends to change to include and accommodate many more types of bacterial and fungi.
The gut microbiota is an integral part of our digestive processes and simply would have adapted to our most common dietary habits.
After some years, the composition of human intestinal microbiota would normally have stabilised, though this can also often mean that it is likely to react to new, unexpected foods – having a stable gut flora attuned to only one environment is a plausible explanation for why some people get ill eating foreign food or certain new foods.
Unusual or alien foods (especially foreign spices, foreign additives, et cetera) may not be well-received by the gut bacteria or the gut itself and can cause reactions such as intestinal pains, constipation or diarrhoea.
And this sensitivity makes sense, especially if you consider that each human has around 30 trillion human cells symbiotically co-existing with a greater number (40 trillion) of bacteria of various strains – human health depends enormously on bacteria and ingested items which confound or damage our natural bacterial flora also damage our health.

Lactose, or usually a sign of trouble

Curiously, over 65% of human adults are intolerant of lactose, even though lactose is the primary sugar in breast milk and also dairy milk.
While human infants are capable of producing the enzyme lactase to digest lactose, the lactase-phlorizin hydrolase or LPH gene controlling the production of lactase peaks between the ages of two to 11 months and normally declines markedly after about the age of five years.
There appears to be no evolutionary benefit in maintaining the LPH gene past a certain age as lactose is normally only found in human breast milk and lactase is not required once a baby has weaned.
milk
Even though over 65 of human adults are intolerant of lactose, people are encouraged to ingest milk and dairy products on the basis that such products provide extra minerals and nutrients such as calcium and Vitamin D. Photo: TNS
It should be noted that dairy farming is a recent development in human evolution, dating from only around 10,000 years ago – it is also not prevalent around the world and therefore most humans have still not adapted to digesting the lactose in cows’ milk.
Apart from humans, no other species on Earth constantly consumes the milk of another species.
Saying that, the LPH gene in some humans has been found to continue into adulthood due to a genetic mutation identified mostly in communities historically involved with dairy farming.
But the fact remains that most people are incapable of drinking a glass of milk without suffering some discomfort. This discomfort arises due to lactose sitting around undigested in the gut, pulling in water and nutrients like a viscous, sticky sludge, causing diarrhoea, bloating, flatulence and possibly also vomiting.
It is also highly plausible that lactose intolerance can lead to other side effects outside of the intestinal tract, such as skin problems or respiratory issues, for example.
Studies have found that well over 90% of Chinese and Japanese people are lactose intolerant, along with over 85% of Asian Indians and over 75% of Africans.
In these populations, one would suggest that a consumer warning would be appropriate for foods containing lactose, though that is seldom provided, at least not in the EU where over 12% of the population is also lactose intolerant.
In fact, most people are encouraged to ingest milk and dairy products on the basis that such products provide extra minerals and nutrients such as calcium and Vitamin D which should help prevent bone diseases such as osteoporosis.
However, this advice may be flawed as people who drink a lot of milk also exhibit the highest incidence of bone fractures, especially in old age.
A Swedish study in 2014 covering 61,433 women and 45,339 men implied that higher mortality and higher bone fracture rates, particularly hip fractures in women, were linked to higher consumption of milk (though other factors were also likely involved).
However, regular outdoor exercise was linked to a reduced likelihood of osteoporosis.
Interestingly, many dairy products such as yoghurts and cheeses are fermented with bacteria from the lactobacillus and bifidobacterium species which can survive as part of the intestinal microbiota.
Although it has been claimed that these lactic acid bacteria can produce lactase in the gut, no convincing evidence has been found to support this – it is much more likely these strains of bacteria break down milk lactose into other compounds which are more digestible by humans.
Various strains of lactobacillus and bifidobacterium are commonly used in the production of dairy goods and this may be a reason why many people can tolerate dairy-based products rather well, even if they cannot tolerate milk itself.
So if you enjoy dairy products, then a suggestion might be to eat more aged cheeses and probiotic yoghurts rather than milk shakes and cream pies.
This widespread intolerance of lactose by humans might easily be misinterpreted as an intolerance of meat, as meat is often presented with creamy sauces of dairy origin.
Also, many Western desserts after meals are often based on milk products and usually difficult to digest for many people – I personally now avoid dense creamy confections after meals as they simply make me sleepy and slightly nauseous.

Eating (some) meat may be bad

To be brutally honest, eating meat in some places is possibly pretty bad for health – this is due to the extensive use of growth-enhancing agents in some countries during the raising of livestock, or the subsequent treatments during meat processing, or the general poor quality of the meat itself.
Ingesting meat loaded with additives such as antibiotics, hormones, disinfectants, preservatives (such as nitrates and nitrites) can significantly damage human intestinal microbiota as well as other parts of the body.
As an example, the impact of animal growth hormones is considered so severe that the EU has banned for years hormone-treated beef from the United States.
Also, many people think that cooking meat kills all toxins and renders cooked meat safe, even bad meat. This is strictly not true – proper cooking can kill all food bacteria (and parasites) but some toxins produced by bacteria before cooking are often not affected by normal cooking processes.
Examples would be the botulism toxin produced by Clostridium botulinum which requires 10 minutes of boiling before deactivation, the enterotoxins produced by Staphylococcus aureus can survive even longer periods of boiling, and the toxins from Bacillus cereus seem impervious to any levels or durations of cooking heat.

spinach
Workers harvesting Chinese spinach.
Not only meat – plant agriculture is also problematic
But to be fair, it is not just meat that is potentially injurious to health – many plant products are treated and contaminated with pesticides and chemical preservatives as well.
There are hundreds of depressing statistics about the types and degrees of pesticide contamination of cereals, nuts and fruits – and that is just the breakfast items.
Furthermore, I am still personally uncomfortable as to why safety research on genetically modified organism (GMO) food seems to be always restricted to 90 days.
If you are now also curious, a relevant article on GMO is on http://www.star2.com/living/viewpoints/2016/01/10/the-verdicts-still-out-on-gm-food/
The extensive use of pesticides for both intensive and GMO farming is also causing huge ecological damage to world insect populations, particularly bees and other beneficial insects.
In Germany, a 2017 study of nature reserves have found an alarming 75% drop in the number of insects compared to just 27 years ago.
Without insects, it is possible that the global agricultural food chain can be severely disrupted, especially for the many fruits and crops that depend on insect pollination.
Part 4 looks into some awkward questions about our diets, especially for people who love eating meat, such as me.

Wednesday, 25 October 2017

Eat Your Prunes - MUST READ

A surprisingly delicious, versatile and nutritious snack, the humble dried plum offers an incredible number of health improvements, such as lowering your risk of heart disease and osteoporosis. Due to high amounts of fiber, they're also noted for easing constipation, a very popular benefit.

October 16, 2017 

Prunes Benefits

Story at-a-glance

  • Prunes are simply dried plums, just like raisins are dried grapes. More specifically, prunes are sun-dried plums that skipped the fermentation process
  • For centuries, traditional medicine made use of prunes for treating fever, high blood pressure, jaundice, diabetes, digestion and constipation, still one of this dried fruit’s most popular remedies
  • Fiber, potassium, iron and retinol from vitamin A, plus high amounts of vitamin K, iron and boron are nutrients in prunes, providing antioxidants, flavonoids and polyphenols for health advantages throughout your body
  • Eating prunes may help prevent bone loss and improve gut health and has been shown in multiple studies to help prevent colon cancer
By Dr. Mercola
If your impression of prunes is that they're something old people eat for help with regularity (although there is that), you could use a bit more information about the benefits of this delicious food. For some people, prunes have somehow gleaned a reputation as dry, mealy and terrible-tasting, but that couldn't be further from the truth. Sure, they may look a little odd, being a wrinkly, purple-to-black lump, but they're tasty to the point of crave worthy.
In case you're not familiar with prunes, they're simply dried plums, just like raisins are dried grapes. More specifically, prunes are sun-dried plums that skipped the fermentation process.1 To make the moist little morsels more intriguing to 25- through 54-year-old females, the California Prune Board asked the Food and Drug Administration (FDA) to begin referring to prunes as "dried plums."
It must be working, as prune consumption shifted. Europe is on the receiving end of 40 percent of the California prune market, and it's jumped 37 percent in just the last year, Fresh Plaza, a global produce news site, notes:
"It is moving away from the traditional home baking and breakfast occasions into the acceptance of prunes as a healthy snack and a versatile ingredient for home cooking. Chefs from all around the world are starting to recognize the significant benefits of including prunes in a whole range of recipes."2
Prunes, much like peaches, are referred to as "freestone," meaning the large pit in the center can stay intact through the drying process, then be easily removed before packaging. Medicine throughout centuries made use of prunes for fever, high blood pressure, jaundice, diabetes, digestion and constipation, still one of its most popular remedies.

Eat Your Prunes — They're Good for You

Just like raisins, prunes offer chewy sweetness and amazing versatility as well as plenty of surprising nutrients. Fiber, potassium, iron and retinol from vitamin A are some of its most prominent nutrients (in fact, the drying process increases the fiber content)3 as are the vitamin K and beta-carotenes.
While I don't recommend you eat an entire cup (174 grams) of pitted prunes in one sitting due to their fructose content (about 5 grams in five prunes4), if you did, you'd get 12 grams, or 49 percent,5 of the recommended dietary allowance (RDI) of fiber, which is what U.S. health organizations say you need for one day (I believe about 50 grams of fiber per 1,000 calories consumed is ideal, however).
Fiber is crucial for moving food smoothly through your colon, which automatically lowers your risk of colon cancer. In fact, two studies — the Prostate, Lung, Colorectal, and Ovarian (PLCO) Screening Trial and another by the European Prospective Investigation into Cancer and Nutrition (EPIC) — noted that "dietary fiber intake is inversely related to the incidence of colon adenomas and cancer."6
Even more recent studies have come to the same conclusion, such as one conducted in 2015 by researchers at Texas A&M. Nancy Turner, AgriLife research professor in the nutrition and food science department, showed that dried plum consumption provides beneficial effects by helping your colon retain advantageous gut microbiota.7
The 36 percent RDI in potassium,8 a mineral crucial for good health, you get from eating 1 cup of prunes helps balance the chemical and electrical processes in your body, lowers your risk of stroke and heart disease along with your blood pressure and optimizes several other important body functions.
In the same cup of prunes, you also get 129 percent of the DRI in vitamin K, which may help prevent inflammation and osteoporosis and improve your insulin sensitivity.9 Other prominent nutrients in prunes include more than 20 percent DRI of several B vitamins10along with notable amounts of vitamin A, calcium, magnesium, zinc, copper, manganese, selenium and boron.

Prunes Should Be Eaten in Moderation

Prunes are a rich source of simple sugars, including fructose. Despite this, research has shown dried plums do not lead to a rapid rise in blood sugar concentration when consumed,11 possibly due to their high fiber and sorbitol content. However, the fructose still constitutes good reason to limit your intake, as is true in regard to consuming most other fruits. Fruits such as plums and prunes can be good for you, but in limited amounts.
One medium prune contains 1.2 grams of fructose. If you're insulin or leptin resistant (are overweight, diabetic, hypertensive or have high cholesterol), then it would be especially advisable for you to limit your fruit intake.
As a general rule, I recommend limiting your fructose intake to a maximum of 15 grams of fructose per day from all sources, including whole fruit. If you are not insulin/leptin resistant (are of normal weight without diabetes, hypertension or high cholesterol) I suggest limiting your fructose intake to 25 grams per day (or less) from all sources.

What Have Prunes Done for You Lately?

Prunes, as you've already read, contain a lot of extremely health-beneficial nutrients. It's how they relate to your body in terms of disease prevention, however, that makes them so valuable. The end conclusion of one study, for instance, reported in the Journal of Medicinal Plants Research, lists several of those benefits:
"Prunes have been found pharmacologically active as antioxidant, anticancer, anxiolytic, mild laxative and antihyperlipedimic. Their efficacy in treatment and prevention of … osteoporosis has been documented in clinical studies.
It exerts positive effects on cardiovascular parameters possibly through antioxidant activities, high fiber and potassium contents. In conclusion, prunes have wide range of nutritional and medicinal uses and daily consumption can be beneficial in the treatment or prevention of different ailments."12
Flavonoid polyphenolic antioxidants in plums, such as lutein and cryptoxanthin, help scavenge free radicals from your body. Free radicals come from toxins that enter your body through your skin and the air you breathe, such as pollution and toxic fumes from household cleaners, food dyes and other unhealthy food ingredients. Free radicals are also produced normally during metabolism. Medical News Today reports:
"Antioxidants, called polyphenols, may prevent cell mutation and reduce cancer cell formation. Prunes were found to have the highest range of polyphenols when compared with other dried fruits, such as raisins, figs, and dates."13
Bahram H. Arjmandi, Ph.D., a registered dietician and researcher at Florida State University, was one of the first to investigate "estrogen receptors in the gut to aid in calcium transport and to demonstrate the efficacy of dried plum in protecting bone in both animal models of osteoporosis and postmenopausal women."14 NDTV's Smart Cooky quotes Arjmandi:
"Over my career, I have tested numerous fruits, including figs, dates, strawberries and raisins, and none of them come anywhere close to having the effect on bone density that dried plums or prunes have. All fruits and vegetables have a positive effect on nutrition, but in terms of bone health, this particular food is exceptional."15

Other Good Things You Get From Eating Prunes

The incredible compounds in prunes provide several benefits that may seem unrelated, which just goes to show you how all-encompassing such nutrients can be. Here are several more super advantages you gain:
1.Prunes are considered heart healthy, mostly due to the potassium content, which optimizes heart function and nerve responses throughout your body. Daily potassium intake helps lower your blood pressure, as well as your risk of heart disease, heart attack and stroke.
2.Prunes help fight osteoporosis, in part due to the boron content, which Alive, a health and wellness site, explains:
"Helps regulate mineral metabolism and optimizes estrogen levels, which in turn increases calcium absorption. Additionally, boron helps convert vitamin D to its active form, which helps the osteoblasts [bone-building cells] utilize calcium for bone formation."16
3.Eating prunes benefits your hair and skin due to the array of vitamins and minerals they provide, which even help slow signs of aging, such as wrinkles. High amounts of iron helps prevent a deficiency that can show up in dry, discolored hair, and even hair loss.
4.Prune consumption benefits your vision due to high vitamin A, which produces retinol. Being deficient in this vitamin is a leading cause of macular degeneration, dry eyes, cataracts and night blindness.
5.The nutrients in prunes go a long way. Nutritionist Anshul Jaibharat offers both a caution and an encouragement:
"Prunes are high in natural sugar, so too many may not be good for people watching their weight. After all, excess of anything is stored as fat in your body. Prunes have such high nutritional values ensuring that you can eat just one piece and still gain measurable nutrients."17

Is Prune Juice Beneficial for Constipation?

You've no doubt heard about the effects of prune juice being a good laxative. In fact, studies have shown it to be even more effective than psyllium husk at treating constipation.18 Prune juice, too, is lauded for decreasing the "transit time" of foods in your digestive tract.
For people with constipation, eating the whole prune may be enough to get things moving, and I recommend trying this first. If the constipation persists, you could try drinking a small amount of prune juice in the morning to help stimulate the desired action. Additionally, another dose half an hour to an hour after a meal might prove helpful, as well.19
I do not, however, recommend drinking prune juice regularly or in large quantities because of the sugar content. If chronic constipation is a problem for you, there are many other natural strategies to treat it. Constipation aside, here are a few more ways to incorporate whole prunes into your diet:
  • Use kitchen shears to cut prunes in smaller pieces to toss into salad greens or mixed with quinoa, coconut and chopped walnuts.
  • They're a great snack for traveling, whether you're in the car or on a walking trail, and even in your lunchbox.
  • An ounce (28 grams) can be added to smoothies for a bit of natural sweetness, as well as extra antioxidants and fiber.
  • Pitted prunes and a little water in your food processor produces a tasty topping for everything from banana bread made from coconut flour to homemade vanilla bean ice cream sweetened with stevia. (As is nearly always the case, the healthiest recipes are those you make yourself.)
  • Try adding a handful of prunes to savory dishes such as chicken with rosemary and basil.
https://articles.mercola.com/sites/articles/archive/2017/10/16/eating-prunes.aspx

Monday, 3 July 2017

Heartburn drugs taken by millions may increase risk of early death, study suggests

Heartburn drugs taken by millions could raise the risk of dying early, a large study suggests.

There are more than 50 million prescriptions a year for heartburn drugs in England 
There are more than 50 million prescriptions a year for heartburn drugs in England 
Heartburn drugs taken by millions could raise the risk of dying early, a large study suggests.

The drugs which are known as proton pump inhibitors, or PPIs - have previously been linked to a variety of health problems, including serious kidney damage, bone fractures and dementia.

The NHS issues more than 50 million prescriptions each year for the medication which is used to treat heartburn, ulcers and other gastrointestinal problems, but researchers say it may be time to restrict the use of the tablets.

The drugs also are available over the counter under brand names including Prilosec, Prevacid and Zegerid .

Researchers examined medical records of more than 275,000 PPI users and nearly 75,000 people who took another class of drugs - known as H2 blockers - to reduce stomach acid.

"No matter how we sliced and diced the data from this large data set, we saw the same thing: there's an increased risk of death among PPI users,” said study senior author Doctor Ziyad Al-Aly, an assistant professor of medicine at Washington University School of Medicine in the United States.

"People have the idea that PPIs are very safe because they are readily available, but there are real risks to taking these drugs, particularly for long periods of time.

“If I needed a PPI, I absolutely would take it. But I wouldn't take it willy-nilly if I didn't need it. And I would want my doctor to be monitoring me carefully and take me off it the moment it was no longer needed.”

Both PPIs and H2 blockers are prescribed for serious medical conditions such as upper gastrointestinal tract bleeding, gastroesophageal reflux disease and esophageal cancer.

Over-the-counter PPIs are most often used for heartburn and indigestion.

The researchers found a 25 per cent increased risk of death in the PPI group compared with the H2 blocker group.

They calculated that, for every 500 people taking PPIs for a year, there is one extra death that would not have otherwise occurred.

Given the millions of people take PPIs regularly, Dr Al-aly said this could translate into thousands of excess deaths every year.

Dr Al-Aly said that although the recommended treatment regimen for most PPIs is short - for example, two to eight weeks for ulcers - many people end up taking the drugs for months or years.

"A lot of times people get prescribed PPIs for a good medical reason, but then doctors don't stop it and patients just keep getting refill after refill after refill,” he added.

"There needs to be periodic re-assessments as to whether people need to be on these. Most of the time, people aren't going to need to be on PPIs for a year or two or three."

Dr Al-Aly said over-the-counter PPIs contain the same chemical compounds as in prescription PPIs, just at lower doses, and there is no way to know how long people stay on them.

Previous studies have found that the drugs raise the risk of hip fractures by 35 per cent and a heart attack by 20 per cent. Last year German scientists found the drugs increase the risk of dementia by 44 per cent.

Prof Tim Spector of King’s College London, author of The Diet Myth, who recently showed that people taking PPIs had abnormal gut microbe communities that predisposed them to infections said:

“Doctors are handing these drugs out like sweets. I would say around 50 per cent of people don’t actually need to be on them.

“This is an observational study and on it’s own maybe doesn't mean a lot but when you start adding it to all the other research it starts to add up.

“These drugs were developed before people even thought about what was happening in your gut.”

The study, published in the journal BMJ Open, concluded: “Emerging evidence suggests that PPIs may boost the risk of tissue damage arising from normal cellular processes, known as oxidative stress, as well as the shortening of telomeres, which sit on the end of chromosomes and perform a role similar to the plastic tips on the end of shoelaces."

However the Proprietary Association of Great Britain, which represents firms making over-the-counter drugs, said: "All over-the-counter medicines have been approved by the Medicines and Healthcare Products Regulatory Agency and are rigorously assessed for safety and efficacy.

"Once on the market, their safety is continually monitored in light of any emerging evidence. Those who may be concerned should speak to their GP or pharmacist before taking any medicine."

http://www.telegraph.co.uk/science/2017/07/03/heartburn-drugs-taken-millions-may-increase-risk-early-death/

Wednesday, 28 June 2017

Is Sparkling Water bad For You? | BBC FUTURE

We’re often warned to go easy on sparkling water, as it may be detrimental to our gut, bones and teeth. But is there any truth in this?


We all know by now that drinking sweet, fizzy drinks all day isn’t a good idea. The combination of a high sugar content coupled with acidity caused by the carbonisation that makes it fizzy, isn’t good. Anyone who has tried leaving coins in a glass of cola overnight knows that they come up shiny and clean. The reason is that phosphoric acid in the drink removes the oxide coating that has built up on the coin. So one alternative is to drink water. “Still or sparkling?” they say to you in restaurants. If you’re not brave enough to say “tap” then sparkling can seem like a nice change.
The chances are though, that if you’re in a group at least one person will say sparkling water is bad for you, but is there any evidence for that claim?
Let’s start with the stomach. Fizzy water is made by adding carbon dioxide under pressure. The result is that water contains the weak acid, carbonic acid. If you gulp it down it can of course give you hiccups or indigestion. But what if you drink it at a more measured pace? Is there any truth in the idea that it harms your stomach?
(Credit: Getty Images)
(Credit: Getty Images)
Quite the reverse, it appears. In a small but double-blinded randomised trial, patients with frequent dyspepsia or constipation were assigned to drink either still or sparkling water for 15 days. Then they were given a series of tests. Both conditions improved in the people drinking sparkling water and showed no improvement in those drinking tap water.
If you drink a lot of sparkling water you might find you feel bloated, but researchers in Japan have found that this side-effect could be put to good use. They had a group of women fast overnight and then slowly drink either still or sparkling water. They found that 900ml of gas was released from just 250ml of water, so not surprisingly the women’s stomachs distended slightly and the had the perception of feeling full, even though they hadn’t eaten. They didn’t feel uncomfortable and so fizzy water has been suggested as a way of avoiding overeating, because it makes you feel fuller.
Bone problems?
And you might have heard people deliberately letting fizzy drinks go flat and then drinking them if they’re dehydrated after a stomach upset or vomiting or even a hangover. But a review of this practice in children with acute gastroenteritis found there’s little evidence that it works and that compared with rehydration powders – specifically constituted to contain replacement salts and sugars in the right proportions – such drinks contain far lower levels of sodium and potassium than you’d find in rehydration drinks. So it’s better to stick to the real thing.
Surely any acid, even a weak one, is going to erode the enamel on our teeth?
But if sparkling water doesn’t damage your stomach, how about your bones?  Does it weaken them? Again, the evidence so far suggests not. A small, Canadian study published in 2001 found that teenagers who drank lots of fizzy drinks (not sparkling water) had less calcium in their bones, but they couldn’t tell whether this was a problem with the drinks themselves or that it was because people who drank them might favour them instead of milk.
The Framingham Heart study began in 1948 and followed a group of people over many years to discover more about the risk factors for heart disease. Now some of their offspring are taking part in the Framingham Osteoporosis Study which involves extensive testing every four years by researchers from Tufts University in Boston. In 2006, the team examined the relationship between bone density and fizzy drinks. They looked in detail at the different types of drink consumed by more 2,500 taking part in the study.
(Credit: Getty Images)
Some people have warned that any sparkling drink - even water - can be bad for us (Credit: Getty Images)
They found that the women (but not men) who drank cola-flavoured fizzy drinks three times a week had hip bones with a lower average bone mineral density. Other carbonated drinks made no difference. The authors hypothesise that the effect is probably down to caffeine and to the actions of phosphoric acid (not found in sparkling water) that are not yet well understood. It’s possible that it might somehow block calcium absorption – but no one yet knows how. Ten years later there is still disagreement over how diet affects bone health.
So as far as bones and stomachs go, so far drinking sparkling water seems to be fine. But how about teeth? Surely any acid, even a weak one, is going to erode the enamel on our teeth? Maybe not. Very little research has been done on sparkling water in particular, but much more has been done on other fizzy drinks. Barry Owens from the University of Tennessee College of Dentistry, Memphis, USA conducted a study back in 2007 comparing different fizzy drinks. In his study, cola-based drinks came out as most acidic, followed by diet-based cola drinks, followed by coffee.
Cumulative effect
He argues that it’s not just the initial pH of a drink that matters, but how strongly the drink retains that acidity in the presence of other substances, because in a real-life mouth saliva is present, as well as other foods which might affect the levels of acidity. This is known as the buffering capacity. A review of different drinks puts them in the following order for their buffering capacity. Non fruit-based carbonated drinks such as cola came out as the most acidic (with diet versions doing slightly better), followed by fruit-based fizzy drinks, fruit juice and then coffee. In other words, some fizzy drinks can damage the hardness of the enamel.
By taking slices of enamel and immersing them in different soft drinks for six, 24 and 48 hours, Poonam Jain at Southern Illinois University School of Dental Medicine demonstrated that the enamel does begin to erode. Some argue that this isn’t very like real life because we don’t keep a drink in our mouth for that length of time. But over the course of many years, even a few seconds each slurp adds up.
(Credit: Getty Images)
The eroding effects of sweet fizzy drinks add up over time (Credit: Getty Images)
A case study published in 2009 of a 25-year-old bank worker whose front teeth wore out after four years of drinking half a litre of cola a day, followed by three years where he upped that to a litre-and-a-half each day and added in some fruit juice, is enough to frighten anyone. But it also depends on how you drink it. This man was described as “holding the drink in the mouth for several seconds and tasting before swallowing”. In Sweden researchers compared short-sipping, long-sipping, gulping, nipping (whatever that might be) and sucking. They found that the longer a drink stayed in the mouth, the more noticeable the drop in pH in that person’s mouth. In other words, the more acidic the mouth becomes. But if you drink through a straw the drink goes straight to the back of your mouth and there’s less opportunity for damage.
But what about sparkling mineral water? At the University of Birmingham, Catriona Brown put extracted human teeth without signs of erosion into jars for 30 minutes with different kinds of flavoured sparkling water to see what happened. The teeth had been coated in varnish, apart from a half-a-centimetre-diameter test area which was left unvarnished. They found the effect of the drinks on the teeth was the same and sometimes greater than the effect of orange juice, a drink which is already known to soften tooth enamel. Lemon and lime, and grapefruit were the most acidic flavours, probably because they use citric acid to give the nice taste.
(Credit: Getty Images)
Sparkling water turns out to be only 1% as acidic as sugary sodas, research suggests (Credit: Getty Images)
So flavoured mineral waters shouldn’t be considered as harmless as water, but how about sparkling water with no added flavours?  Studies on this are few and far between. But in 2001, the Birmingham team examined seven different brands of mineral water, again pouring them over extracted teeth to see what happened. They found sparkling waters had a pH of between 5 and 6 (so not as acidic as some cola drinks which can be as high as 2.5), compared with still water which was neutral at 7. In other words, they are a weak acid, as suspected. But when it came to the erosive potential of that weak acid on the teeth, the effect was 100-times less than that of some other kinds of fizzy drinks. Of course the mouth itself is a different environment from a jar, but so far the evidence for harm doesn’t seem to be very strong.
So if you want a change from plain old water, then although it’s mildly acidic, so far there isn’t strong evidence to suggest that it’s harmful to your bones, your stomach or your teeth. But if you want to play safe and keep it away from your teeth, when you answer the question “still or sparkling”, perhaps you should also ask for a straw. 


http://www.bbc.com/future/story/20150911-is-sparkling-water-really-bad-for-you

Friday, 12 May 2017

Why Aged Cheese and Mushrooms Are so Good for Your Heart (and Make You Live Longer Too)

Until recently, it's been vetoed by health experts, but could this forbidden food actually help you manage your health, improve cholesterol levels,...

May 08, 2017

metabolism

Story at-a-glance-

  • Polyamines such as spermidine, spermine and putrescine are derivatives of amino acids, found both in food and your gut microbiota, and are critical for cellular growth and survival
  • Polyamines have potent anti-inflammatory activity, protect your DNA against free-radical damage and have been linked to longevity
  • In one recent study, those who had the highest spermidine levels had a 40 percent lower risk of heart failure

By Dr. Mercola
Cheese can be an excellent source of nutrition, especially if made from unpasteurized grass fed milk and aged according to tradition. Among the many valuable nutrients in real cheese is vitamin K2, which is important for heart, brain and bone health. The highest amounts of vitamin K2 can be found in Gouda, Brie and Edam. Other cheeses with lesser but still significant levels of K2 include cheddar, Colby, hard goat cheese, Swiss and Gruyere.
Cheese also provides a cornucopia of other vitamins (including vitamins A, D, B2 and B12), minerals (including calcium, zinc and phosphorous), amino acids and protein, as well as high-quality saturated and omega-3 fats. In recent years, a number of studies have exonerated cheese (especially full-fat cheese), showing higher cheese consumption results in improved health and aids weight management. For example:
  • High-fat cheese has been shown to raise your high-density lipoprotein (HDL) cholesterol,1,2 thought to be protective against metabolic diseases and heart disease
  • Cheese consumption also helps prevent fatty liver and improves triglyceride and cholesterol levels3 — parameters used to gauge your cardiovascular disease risk
  • Full-fat cheese can be useful for weight management,4 in part by ramping up your metabolism5
  • Roquefort cheese in particular has been linked to cardiovascular health and improved longevity, courtesy of its anti-inflammatory properties6,7
Now, researchers have discovered yet another major compound in many cheeses that helps explain its beneficial impact on your health.

Polyamines in Cheese Linked to Longevity and Lower Disease Risk

Polyamines are derivatives of amino acids, found both in food and your gut microbiota, and are critical cellular growth and survival. Polyamines in turn contain chemicals such as spermidine and spermine (thus named as they were originally discovered in human semen) and putrescine. As noted by the Royal Society of Chemistry: 8
“Spermine derives from spermidine. And, spermidine, with the help of spermidine synthase, arises from another polyamine originally named for its role in rotting meat, called putrescine … [T]hese polyamines are the reason why sperm and, in the springtime, some species of trees, give off a spunky [odor] …”
Spermidine, spermine and putrescine all have potent anti-inflammatory activity, protect DNA against free-radical damage, and have been linked to longevity in animal studies — even when the animals were given the polyamines starting in middle age. As a group, polyamines are positively charged molecules that strongly interact with negatively charged molecules such as DNA, RNA and proteins. This is why they’re so important for cellular processes involving growth, division, differentiation and survival.

Spermine Protects Against Heart Disease

Studies have repeatedly demonstrated that when you increase levels of polyamines in an organism (including humans), cellular activity goes up and mortality goes down,9 in part by improving cardiovascular function and lowering blood pressure.10 In one recent study, which included 800 cheese-loving Italians, those who had the highest spermidine levels had a 40 percent lower risk of heart failure.11
In another,12 spermine was not only found to offer potent protection against heart disease in both animals and humans, it was even found to counteract the adverse effects of a high-salt diet in salt-sensitive mice:
“[O]ral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with … suppressed subclinical inflammation …  
In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure.
In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.”

Polyamines Help Combat Visible Signs of Aging and Increase Lifespan

Previous research showed transgenic mice bred to not produce spermine and spermidine suffered hair loss, developed more skin wrinkles and died at an earlier age than normal mice,13 suggesting polyamines play an important role in combating both visible signs of aging and early death.
Importantly, polyamines encourage cellular autophagy,14,15 which has serious implications for longevity. Autophagy means "self-eating" and refers to the processes by which your body cleans out debris, including toxins, and recycles damaged cell components — processes that tend to decline with age.
Lifetime feeding studies using rodents have linked spermidine-rich diets to as much as a 25 percent increase in lifespan.16,17,18 In human terms, that equates to an average lifespan of 100 rather than 81.
Animals given spermidine at a later age gained about 10 percent in longevity, which can still amount to several years’ worth of life for a human. As noted by Leyuan Liu, Ph.D., assistant professor at the Texas A&M Institute of Biosciences and Technology's Center for Translational Cancer Research:19
"Only three interventions — severely cutting the number of calories consumed, restricting the amount of methionine (a type of amino acid found in meat and other proteins) in the diet and using the drug rapamycin — have been shown to truly prolong the lifespans of vertebrates, but eating less and not eating meat will not be welcomed by [the] general population, while rapamycin has shown to suppress the human immune system. Therefore, spermidine may be a better approach."
Aside from its general anti-aging influence, autophagy is also one of the mechanisms by which polyamines help protect against cancer (specifically liver cancer20,21) and Alzheimer’s disease.

Polyamines Correct Your Internal Body Clock

Interestingly, recent research22 has also shown that polyamines have the ability to restore your internal body clock, suggesting it might serve as a natural sleep aid. Improving sleep also helps lower your risk of chronic disease — including cancer and Alzheimer’s — and is important for longevity. According to the authors:
“Polyamines are … present in all living cells. Polyamine levels are maintained from the diet and de novo synthesis, and their decline with age is associated with various pathologies. Here we show that polyamine levels oscillate in a daily manner.
Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis … In turn, polyamines control the circadian period in cultured cells and animals by regulating the interaction between the core clock repressors PER2 and CRY1.
Importantly, we found that the decline in polyamine levels with age in mice is associated with a longer circadian period that can be reversed upon polyamine supplementation in the diet. Our findings suggest a crosstalk between circadian clocks and polyamine biosynthesis and open new possibilities for nutritional interventions against the decay in clock’s function with age.”

Fermentation Boosts Polyamine Content

Polyamines are found in many different foods, including the following (see listing below):23,24,25 As a general rule, fruits and cheese contain the highest levels of putrescine, vegetables have the highest levels of spermidine, and meat products have the most spermine.26 Research also shows polyamine levels are further increased through fermentation.
The Mediterranean diet, high in fresh vegetables and seafood, typically contains twice the amount of polyamines found in the average diet27 (which tends to be high in processed foods), and some scientists suggest the high polyamine content may be why the Mediterranean diet has such a positive influence on health and longevity.
Aged (fermented) cheese such as blue cheese, cheddar, Swiss, Brie, Gruyere, Manchego, Gouda and Parmesan28,29
Shell fish, including squid, oysters, crabs and scallops
Fermented foods such as sauerkraut and miso
Cruciferous veggies such as broccoli, cauliflower
Leafy greens
Pears
Green peas
Wheat germ
Nuts and seeds, including hazelnuts, almonds, pistachios and peanuts
Chicken liver

Potential Contraindications

Some scientists and oncologists do warn that polyamine-rich diets may be contraindicated for those with psoriasis, as rapid skin cell regeneration may worsen the condition,30 and certain polyamine-sensitive cancers, such as prostate cancer. As noted in one study,31
“… [D]ifferences in biological [behavior] of prostatic (cancer) cells are associated with changes in polyamine levels and/or the activity of their metabolic enzymes. Faulty antizyme regulation of polyamine homoeostasis may play an important role in the growth and progression of prostatic carcinoma. Treatment of human prostate carcinoma cells with inhibitors of polyamine metabolic enzymes or polyamine analogues induces cell growth arrest or (apoptotic) cell death.”

Eat Real Food for Optimal Health

If you love cheese, there’s plenty of evidence to suggest real cheese is a boon to your health, and there’s no reason to avoid it for fear of its fat content. The healthy fats found in real cheese will neither pack on pounds nor contribute to heart disease. On the contrary, these fats will actually boost your weight loss success and lower your cardiovascular health risks.
One caveat is to make sure you’re eating real cheese. Natural cheese is a simple fermented dairy product made with just a few basic ingredients — milk, starter culture, salt and an enzyme called rennet. Salt is a crucial ingredient for flavor, ripening and preservation.
You can tell a natural cheese by its label, which will state the name of the cheese variety, such as “cheddar cheese,” “blue cheese” or “Brie.” Real cheese also requires refrigeration. Processed cheeses are typically pasteurized and otherwise adulterated with a variety of additives that detract from their nutritional value. The tipoff on the label is the word “pasteurized.”
A lengthier list of ingredients is another way to distinguish processed cheese from the real thing. Velveeta is one example, with additives like sodium phosphate, sodium citronate and various coloring agents. A final clue is that most processed cheeses do not require refrigeration. So, be it Velveeta, Cheese Whiz, squeeze cheese, spray cheese or some other imposter — these are not real cheeses and have no redeeming value.
Even if you don’t like cheese, there are plenty of other foods rich in polyamines, as you can see from the list above, with fermented foods and beverages having some of the highest levels. Following a Mediterranean-style diet is one way to ensure you’re getting plenty of these anti-inflammatory, anti-aging compounds.