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Showing posts with label Bile. Show all posts
Showing posts with label Bile. Show all posts

Friday, 17 August 2018

Antitumor immune function in liver and gut microbiome - MUST READ

NCI study finds gut microbiome can control antitumor immune function in liver

  • Posted: May 24, 2018






3D illustration of gut bacteria.
Credit: iStock
Healthwise

Scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver. Their study, published online May 24 in Science, was led by researchers in the Center for Cancer Research (CCR) at the National Cancer Institute (NCI). 
It showed that bacteria found in the gut of mice affect the liver’s antitumor immune function. The findings have implications for understanding the mechanisms that lead to liver cancer and for therapeutic approaches to treat them. NCI is part of the National Institutes of Health. 
“What we found using different tumor models is that if you treat mice with antibiotics and thereby deplete certain bacteria, you can change the composition of immune cells of the liver, affecting tumor growth in the liver,” said Tim Greten, M.D., of NCI’s CCR, who led the study. “This is a great example of how what we learn from basic research can give us insight into cancer and possible treatments.” 
The microbiome is the collection of bacteria and other microorganisms that live in or on the body. In humans, the greatest proportion of the body’s total microbiome is in the gut. Despite extensive research into the relationship between the gut microbiome and cancer, the role of gut bacteria in the formation of liver cancer has remained poorly understood. 
To investigate whether gut bacteria affect the development of tumors in the liver, Dr. Greten and his team carried out a series of experiments with mice. They used three mouse models of liver cancer, and found that when they depleted gut bacteria using an antibiotic “cocktail,” the mice that had the antibiotics developed fewer and smaller liver tumors and had reduced metastasis to the liver.
The investigators next studied the immune cells in the liver to understand how the depletion of gut bacteria suppressed tumor growth in the liver of the antibiotic-treated mice. Antibiotic treatment increased the numbers of a type of immune cell called NKT cells in the livers of the mice. Further experiments showed that, in all three mouse models, the reduction in liver tumor growth that resulted from antibiotic treatment was dependent on these NKT cells. Next, they found that the accumulation of the NKT cells in the liver resulted from an increase in the expression of a protein called CXCL16 on cells that line the inside of capillaries in the liver.
“We asked ourselves, why do mice treated with antibiotics have more CXCL16 production in these endothelial cells?” Dr. Greten said. “That was the critical point, when we found that bile acids can control the expression of CXCL16. We then did further studies, and found that if we treat mice with bile acids, we can actually change the number of NKT cells in the liver, and thereby the number of tumors in the liver.”
Bile acids are formed in the liver and help break down fats during digestion.
Finally, the investigators found that one bacterial species, Clostridium scindens, controls metabolism of bile acids in the mouse gut—and ultimately CXCL16 expression, NKT cell accumulation, and tumor growth in the liver.
Dr. Greten explained that while many studies have shown an association between gut bacteria and immune response, this study is significant in that it identifies not just a correlation, but a complete mechanism of how bacteria affect the immune response in liver. In the same study, the researchers found that bile acids also control the expression of the CXCL16 protein in the liver of humans and wrote that, though these results are preliminary, the novel mechanism described in this study could potentially apply to cancer patients. 
This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process—each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research. 
About the Center for Cancer Research (CCR): CCR comprises nearly 250 teams conducting basic, translational, and clinical research in the NCI intramural program—an environment supporting innovative science aimed at improving human health. CCR’s clinical program is housed at the NIH Clinical Center—the world’s largest hospital dedicated to clinical research. For more information about CCR and its programs, visit ccr.cancer.gov
About the National Cancer Institute (NCI): NCI leads the National Cancer Program and NIH’s efforts to dramatically reduce the prevalence of cancer and improve the lives of cancer patients and their families, through research into prevention and cancer biology, the development of new interventions, and the training and mentoring of new researchers. For more information about cancer, please visit the NCI website at cancer.gov or call NCI’s Contact Center (formerly known as the Cancer Information Service) at 1-800-4-CANCER (1-800-422-6237). 
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit nih.gov.



Tuesday, 26 July 2016

How Perfect Is Your Poop?

A new online tool helps analyze your stool using information you input about its shape, color, size and more. Once you learn if your stool needs improving, dietary changes are offered to improve your bowel health.

modern toilet

July 23, 2016 

Story at-a-glance

  • The appearance and frequency of your stool gives you clues about how your gastrointestinal tract is functioning and can even signal serious disease processes that could be occurring
  • StoolAnalyzer is an online tool to help you analyze your stool and make dietary changes to improve the health of your bowel movements
  • Healthy stool should be torpedo shaped, soft and easy to pass, not hard, dry or overly loose

By Dr. Mercola
The size, shape and color of your bowel movements can tell you a lot about your health. This is why you should take a minute to observe what's in the toilet bowl before flushing it away.
The "perfect" stool should be shaped like a torpedo. It should be smooth, soft and easy to pass, as opposed to small and hard (pellet-like) or overly loose.
The appearance and frequency of your stool gives you clues about how your gastrointestinal tract is functioning and can even signal serious disease processes that could be occurring, like infections, digestive problems and even cancer.
Further, making dietary changes will often lead to significant changes in your stool, which you can use as a visual tool to monitor your underlying health.

Analyze Your Stool Online Using StoolAnalyzer

Because you're living in the 21st century, it's no longer necessary to make guestimates about what type of changes you should make to improve your health and, thereby, the condition of your stool. You can instead use an online tool called StoolAnalyzer to make these suggestions for you.1
As it says on StoolAnalyzer.com, "This program is designed to help you analyze your feces and change your diet so that you can achieve the 'perfect stool.'"2 The program takes just a few minutes to complete and includes visual images to help you analyze your poop, asking questions regarding your poop's:
  • Shape
  • Color
  • Size
  • Frequency
  • Behavior (floating versus sinking)
You'll receive a score based on a 100-point scale (with 100 being a perfect score) along with dietary recommendations to improve the health of your stool.
This is not a substitute for an ongoing relationship with a holistic health care provider, but it can give you an idea of what's healthy and what's not when it comes to your stool.

The Bristol Stool Chart

Another handy tool for gauging the health of your digestive tract and stool is the Bristol Stool Chart. Like StoolAnalyzer, this chart takes into account shape and texture of your stool, as well as how difficult or easy it is to pass.
Normal stool is shown in types 3, 4 and 5, "like a sausage or a snake, smooth and soft" to "soft blobs that pass easily." Type 4, however, is ideal.3

Signs of Healthy Vs. Unhealthy Stool

The next time you have a bowel movement, compare what you see in the toilet with the information in the chart below. You should be able to accurately gauge whether your stool is healthy or unhealthy.
If yours is the latter, it's time to make some dietary changes and consult with a holistic health professional to figure out what's gone awry in your digestive tract.
Healthy StoolUnhealthy Stool
Medium to light brown
Stool that is hard to pass, painful, or requires straining
Smooth and soft, formed into one long shape and not a bunch of pieces
Hard lumps and pieces, or mushy and watery, or even pasty and difficult to clean off
About 1 to 2 inches in diameter and up to 18 inches long
Narrow, pencil-like or ribbon-like stools: can indicate a bowel obstruction or tumor; narrow stools on an infrequent basis are not so concerning, but if they persist, definitely make a call to your physician
S-shaped, which comes from the shape of your lower intestine
Black, tarry stools or bright red stools may indicate bleeding in the GI tract; black stools can also come from certain medications, supplements or consuming black licorice.
If you have black, tarry stools, it's best to be evaluated by your health care provider
Quiet and gentle dive into the water; it should fall into the bowl with the slightest little "whoosh" sound — not a loud, wet cannonball splash that leaves your toosh in need of a shower
White, pale or gray stools may indicate a lack of bile, which may suggest a serious problem (hepatitis, cirrhosis, pancreatic disorders, or possibly a blocked bile duct), so this warrants a call to your physician. Antacids may also produce white stool.
Natural smell, not repulsive (I'm not saying it will smell good)
Yellow stools may indicate giardia infection, a gallbladder problem, or a condition known as Gilbert's syndrome. If you see this, call your doctor.
Uniform texture
Presence of undigested food (more of a concern if accompanied by diarrhea, weight loss, or other changes in bowel habits)
Sinks slowly
Floaters or splashers
Increased mucus in stool: This can be associated with inflammatory bowel disease like Crohn's disease, or ulcerative colitis, or even colon cancer, especially if accompanied by blood or abdominal pain
Very bad odor: If your stool has an extraordinarily bad odor, it should not be ignored. I am referring to an odor above and beyond the normally objectionable stool odor.
Stinky stool can be associated with a number of health problems, such as a malabsorptive disorder, Celiac disease, Crohn's disease and chronic pancreatitis.

How Often Should You Poop?

There is a wide variation in what's considered normal bowel-movement frequency. Specifically, three bowel movements per day to three per week may be normal for you, and the frequency may change from day to day or week to week. This is because many factors influence your bowel habits, including:
Diet
Travel
Medications
Hormonal fluctuations
Sleep patterns
Exercise
What's most important is to monitor how you feel and how easily your bowel movements occur. If you're not moving your bowels often enough, you may need to push or strain, and you may feel uncomfortably bloated or gassy. When you do go, the stool may be dry and hard or pellet-like, which are signs of constipation.
Straining is not normal during a bowel movement, nor is experiencing feelings of incomplete elimination, bloating, crampiness or sluggishness after going number two. If you're over the age of 65, your risk of becoming constipated increases significantly.
Chronic, untreated constipation can lead to fecal impaction, which can be a serious medical condition. Laxatives should be avoided at all cost and used only as a last resort, not only due to the potential side effects but also because your body may become dependent on them.
Laxatives may decrease your colon's ability to contract and can even eventually damage your large intestine's nerves, muscles, and other tissues. Fortunately, although constipation is very common, it is also usually temporary and relatively easy to resolve — without resorting to laxatives — by using the natural strategies at the end of this article.

You're Probably Missing Out on These Two Pooping Principles

If you're an adult, you may think you know all there is to know about moving your bowels. However, if you live in the developed world you may be missing out on a key strategy that could make pooping much easier: squatting.
Your body is designed to eliminate while squatting, while modern-day toilets put your body in an unnatural position. Sitting on a modern toilet is designed to place your knees at a 90-degree angle to your abdomen while squatting places your knees much closer to your torso.
This changes the spatial relationships of your intestinal organs and musculature, optimizing the forces involved in defecation. Squatting straightens your rectum, relaxes your puborectalis muscle and allows for complete emptying of your cecum and appendix without straining, which prevents fecal stagnation and the accumulation of toxins in your intestinal tract.
Non-westernized societies, in which people squat, do not have the high prevalence of bowel disease seen in developed nations; in some cultures with traditional lifestyles, these diseases are uncommon or almost unknown. Special toilets and stools that get your body into a more "squatty" position can help you get closer to the ideal even if you've been sitting for decades. What's the other pooping principle you may be missing out on?
A bidet! Bidets provide superior hygiene, are gentler on your skin and are better for the environment than toilet paper; with a bidet seat, you can even install one right on your existing toilet. Bidets are common in certain parts of Europe, South America, the Middle East and Japan; they haven't caught on widely in the U.S., but their use does appear to be increasing.4

Tips to Optimize Your Bowel Movements

The strategies that follow will help to optimize your digestive health, reverse and prevent constipation and support healthy bowel movements. They're safe for children and adults alike.
Remove all sources of gluten from your diet (the most common sources are wheat, barley, rye, spelt and other grains)
Eat a diet that includes whole foods, rich in fresh, organic vegetables and fruits that provide good nutrients and fiber; most of your fiber should come from vegetables, not from grains
Avoid artificial sweeteners, excess sugar (especially fructose), chemical additives, MSG, excessive amounts of caffeine and processed foods as they are all detrimental to your gastrointestinal (and immune) function
Boost your intestinal flora by adding naturally fermented foods into your diet, such as sauerkraut, pickles, and kefir (if you tolerate dairy); add a probiotic supplement if you suspect you're not getting enough beneficial bacteria from your diet alone
Increase your fiber intake; good options include psyllium and freshly ground organic flax seed (shoot for about 50 grams of fiber per 1,000 calories consumed daily)
Make sure you stay well hydrated with fresh, pure water
Get plenty of exercise daily
Avoid pharmaceutical drugs, such as painkillers like codeine or hydrocodone, which will slow your bowel function.
Antidepressants, and antibiotics can also cause a variety of GI disruptions
Address emotional challenges with tools like the Emotional Freedom Techniques (EFT)
As mentioned, consider squatting instead of sitting to move your bowels, which has been scientifically shown to relieve constipation and hemorrhoids

http://articles.mercola.com/sites/articles/archive/2016/07/23/healthy-stool.aspx?

Monday, 4 July 2016

The Surprising Health Benefits of Unripe Banana, Papaya and Mango

As these foods ripen, their starch converts into sugars. Not only that, their nutritional content changes too. One of these unripe foods contains more vitamin C than ripened ones and all of them give your gut a healthy boost by their levels of digestive-resistant starches that slowly ferment in your large intestine, acting as prebiotics.

July 04, 2016 

Story at-a-glance

    healthy fruits
  • Green (unripened) banana, papaya and mango contain higher amounts of digestive-resistant starch than ripe ones, which is important for optimal gut health. Sample recipes are included
  • Unripe banana is composed of as much as 80 percent starch, most of which is digestive-resistant starch. As the banana ripens, the starch gets converted into sugars
  • Unripe Langra mango has as much vitamin C as 35 apples or nine lemons, and while ripe and unripe papaya are both rich in antioxidants and fiber, green papaya contains higher amounts of potassium
By Dr. Mercola
Are you getting enough fiber in your diet? If not, your health may suffer in more ways than one. A common sign your diet is lacking in fiber is constipation and irregular bowel movements, but that's really just the tip of the iceberg.
Fiber-rich foods like vegetables promote optimal gut health by nourishing beneficial gut bacteria. Certain fruits are also high in fiber, including underripe bananas, papayas and mangoes.
These fruits have yet another feature that makes them interesting. Their nutritional content changes depending on their ripeness, and in their unripened state, they contain higher amounts of digestive-resistant starch, which is important for optimal gut health.1
The idea that an unripe fruit might be healthier than a ripe one may seem seriously counterintuitive.
The sugar content of a fruit is typically used as an indicator of quality — not because the sugars are in and of themselves necessarily an indicator of quality, but they're typically associated with the plant's mineral content. Hence, it can be used as a marker of quality.
To measure sugar content, a refractometer or so-called Brix meter is used. The most common Brix meters measure on a scale of 0 to 32 degrees Brix, and the sweeter the fruit, the higher the nutritional content is thought to be.
However, in the case of mango, its vitamin C content is actually much higher in the unripe fruit than in the ripened one. Vitamins and minerals are also not the sole reason for eating fruits though. Fiber is also important, and in some cases unripe fruit is a better option.

What's so Great About Digestive-Resistant Starch?

Fiber is typically classified as either soluble or insoluble. However, from a health standpoint, the fermentability of the fiber is what's really important. Digestive-resistant starches are low-viscous fibers that resist digestion in the small intestine and slowly ferment in your large intestine.2
Here, resistant starches act as prebiotics, feeding healthy bacteria. Due to their slow fermentation, they won't make you gassy. They also add significant bulk to your stools, and help you maintain regular bowel movements.
Best of all, since they're indigestible, resistant starches do not result in blood sugar spikes. In fact, research suggests resistant starches help improve insulin regulation, reducing your risk of insulin resistance.3,4,5,6
Besides underripe banana, papaya and mango, other foods high in resistant starch include white beans, lentils, seeds and products like potato starch, tapioca starch and brown rice flour.
(Interestingly, cooking a normally digestible starch such as potato or pasta and then cooling it in the refrigerator will alter the chemistry of the food, transforming more of it into resistant-type starch.7)

Green Bananas

As noted by Authority Nutrition, "before it ripens, a banana is almost entirely starch, which composes up to 70 to 80 percent of its dry weight. A large part of this starch is digestive-resistant starch. As the banana ripens, the amount of starch and resistant starch decreases and is converted into sugars."8
Because of their high-resistant starch content, green bananas can be used to safely treat diarrhea in children and adults.
Most people don't like the taste and texture of unripe banana, but when prepared properly and combined with other foods it can be quite tasty. Here's a sample recipe for a green banana salad from Cooks.com:9
Green Banana Salad (eight servings)
Ingredients:
2 cups water
1 teaspoon (tsp.) salt
3 green (unripe) bananas, peeled
2 medium carrots, shredded
1 small cucumber, sliced
1 avocado, cubed
1 tomato, chopped
1 celery stalk, sliced
Directions:
1.Place bananas, water and salt in a pot and bring to a boil.
2.Reduce heat, cover and simmer for about five minutes or until the bananas are tender.
3.Drain the water and allow bananas to cool.
4.Cut the bananas into one-half-inch slices and toss with remaining ingredients and vinaigrette dressing (below). Chill and serve.
Vinaigrette Dressing
1/3 cup virgin olive oil
1 clove garlic, chopped
1/2 tsp. dark mustard
2 tablespoons (Tbsp.) wine vinegar
1 tsp. salt
Dash of pepper

Green Papaya

Like bananas, there are some notable differences between ripe and unripe papaya. While both ripe and green (unripe) papaya are rich in antioxidants, fiber and papain, an enzyme that helps with protein digestion and dampens inflammation, green papaya contain higher amounts of papain and potassium.10
Caution is in order though, as unripe papaya contains latex fluid, which may cause an allergic reaction in some individuals, so please be aware of this before you try it.Green papaya is also contraindicated for pregnant women, as it promotes uterine muscle contractions.
On the other hand, women with irregular menstrual cycles may benefit from unripe papaya juice for this same reason.
Perhaps even more so than unripe banana, green papaya typically needs to be incorporated into a recipe with other ingredients in order to satisfy the taste buds. Here's a sample recipe from The New York Times:11
Green Papaya Salad
Ingredients:
1 large clove of garlic, peeled
¼ tsp. salt
1 Tbsp. dry-roasted salted peanuts (plus additional for garnish)
2 fresh bird chilies or serrano chilies, sliced
2 Tbsp. fresh lime juice
1 to 2 Tbsp. fish sauce (nam pla or nuoc nam), to taste
2 plum tomatoes, 1 large round tomato or 8 grape tomatoes, coarsely chopped
1 small to medium green (unripe) papaya (for a total of 4 to 6 cups)
Optional Ingredients:
• 1 Tbsp. dried shrimp
• ½ pound long beans, trimmed and cut into 1.5-inch lengths
• Lettuce for serving
Directions:
1.Using a blender or mortar, mix garlic, salt, peanuts, chilies, sugar and shrimp (if using) into a paste. Transfer to a large bowl and mix in lime juice and fish sauce.
2.Lightly crush tomatoes and beans (if using) with a fork, then add to bowl and mix lightly.
3.Peel and coarsely grate the green papaya. Discard the seed and inner membrane.
4.Lightly fold in the papaya with the rest of the mixture. Season to taste.
5.Line bowl with lettuce leaves and add the papaya salad. Sprinkle with peanuts and serve.

Surprising Health Benefits of Green Mango

There are over 500 varieties of mango, some of the most popular of which include Malda, Alphonso, Langra, Sipia, Sukul and Bumbaiya. Interestingly, unripe mango is an exceptionally rich source of vitamin C. Green (unripe) Langra mango contains as much vitamin C as 35 apples, nine lemons or three oranges.12
I have seven mango trees in my yard that are just about ready to ripen and look forward to trying them underripe. In India, green mango is used as a natural remedy for:
Gastrointestinal (GI) disorders: Green mango, eaten with salt and honey is used to treat a range of GI problems, including diarrhea, dysentery, piles, morning sickness, indigestion and constipation.
Liver problems: The acids in unripe mango increase bile secretion and act as an intestinal antiseptic. It also helps purify your blood and acts as a liver tonic. Green mango with honey and pepper is used for stomach ache due to poor digestion, hives and jaundice.
Blood disorders: The high vitamin C content of unripe mango helps improve blood vessel elasticity and increases formation of new blood cells. It also aids absorption of iron and decreases bleeding. According to the Indian magazine Deccan Herald:13
"Eating an unripe mango daily during the summer season prevents ... infections, increases body resistance against tuberculosis, cholera, dysentery, anemia etc.
It tones the heart, nerves and cures palpitation of the heart, nervous tension, insomnia and weakness of the memory ... Eating raw mango with salt quenches thirst and prevents loss of sodium chloride and iron during summer due to excessive sweating. It tones up the body and helps one to tolerate the excessive heat."
As with green papaya, there's a caveat. Avoid eating more than one unripe mango per day, as it may cause throat irritation and/or indigestion when eaten in excess. Also avoid drinking cold water immediately afterward, as it coagulates the sap, thereby increasing the risk of irritation.

Green Mango Salad

If the idea of eating green mango with salt and honey — as is traditional in India — doesn't appeal to you, here's a sample recipe for green mango salad from Bon Appétit:14
Green Mango Salad (eight servings)
Ingredients:
2 red or green Thai chilies with seeds, chopped
1 clove garlic, chopped
½ cup fresh lime juice
¼ cup fish sauce (nam pla or nuoc nam)
2 Tbsp. olive oil
4 green mangoes, julienne cut
2 medium shallots, sliced
½ cup unsalted, dry-roasted peanuts, chopped
½ cup fresh cilantro
¼ cup fresh mint leaves
2 Tbsp. toasted dried shrimp (optional)
2 Tbsp. toasted sesame seeds
Natural salt, such as kosher or Himalayan salt
Directions:
1.Using a blender, purée chilies, garlic, lime juice, fish sauce and olive oil.
2.Toss mangoes, shallots, peanuts, cilantro, mint, dried shrimp (if using) and sesame seeds in a large bowl and fold in the purée. Salt to taste.

The Importance of Fiber for Health

Remember, fiber is an important component of your diet that can go a long way toward improving your gut microbiome. This in turn will help prevent health problems associated with leaky gut syndrome. Some of the most important byproducts from the fiber fermentation process are short-chain fatty acids like butyrate, propionate and acetate. These short-chain fats:
  • Help nourish and recalibrate your immune system, thereby helping to prevent inflammatory disorders such as asthma and Crohn's disease15,16
  • Increase specialized immune cells called T regulatory cells, which help prevent autoimmune responses. Via a process called hematopoiesis, they're also involved in the formation of other types of blood cells in your body
  • Serve as easy substrates for your liver to produce ketones that efficiently fuel your mitochondria and serve as important and powerful metabolic signals
  • Stimulate the release of a gut hormone known as peptide YY (PYY), which increases satiety, meaning it helps you feel fuller17
  • Butyrate in particular affects gene expression and induces apoptosis (normal programmed cell death), thereby decreasing your risk of colon cancer

Fiber Differentiates 'Good' Carbs From the 'Bad'

Grains, rice, pasta, potatoes, fruits and vegetables are all carbohydrates. However, from a health standpoint they're not created equal, and it's the fiber content that differentiates "good" carbs from the "bad." Most all vegetables and certain fruits are very high in fiber, which means they're very low in net carbs, and when it comes to carbs, it's the net carbs you need to pay careful attention to.
Vegetables typically top the list in terms of high fiber content, but as you can see, certain fruits can fit the bill as well, while adding a bit of "culinary adventure" to your cooking. While there are individual differences, as a general rule, most people could benefit by:
  • Restricting net carbs to less than 50 grams per day (if you exercise a lot or are very active, you might be able to increase it to 100 grams). To determine your net carbs, simply subtract the fiber from the total carbs, and that's your total non-fiber or "net" carbs
  • Increasing fiber to approximately 50 grams per 1,000 calories

http://articles.mercola.com/sites/articles/archive/2016/07/04/unripe-banana-papaya-mango-benefits.aspx